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Safe or Safer? Briefly, nothing is absolutely safe, but as the products continually evolve they become safer. Nicotine Replacement Therapy products such as patches, gums, sprays, and inhalers are substantially less than 1% as risky as smoking. Non-pharmaceutical nicotine products can also pose a fraction of the risk of smoking, e.g. Snus (approximately 1%), E-Cigarettes (less than 5%), and Heat not Burn (approximately 10%). These estimates become ever more refined as increasing numbers of research studies are published. Beyond the debate about nicotine tied to smoking and products used to quit smoking, science is also looking at potential therapeutic benefits of nicotine.