ENDS Cardiovascular System - Revision history

Skip at 19:02, 18 January 2025

2025-01-18T19:02:35Z

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	(Jacob George, MD, Muhammad Hussain, MSc, Thenmalar Vadiveloo, PhD, Sheila Ireland, BSc, Pippa Hopkinson, BSc, Allan D.Struthers, MD, Peter T. Donnan, PhD, Faisel Khan, PhD, Chim C.Lang, MD		(Jacob George, MD, Muhammad Hussain, MSc, Thenmalar Vadiveloo, PhD, Sheila Ireland, BSc, Pippa Hopkinson, BSc, Allan D.Struthers, MD, Peter T. Donnan, PhD, Faisel Khan, PhD, Chim C.Lang, MD
	E-cigarette (EC) use is increasing exponentially worldwide. The early cardiovascular effects of switching from tobacco cigarettes (TC) to EC in chronic smokers is unknown. Meta-analysis of flow-mediated dilation (FMD) studies indicate 13% lower pooled, adjusted relative risks of cardiovascular events with every 1% improvement in FMD.		E-cigarette (EC) use is increasing exponentially worldwide. The early cardiovascular effects of switching from tobacco cigarettes (TC) to EC in chronic smokers is unknown. Meta-analysis of flow-mediated dilation (FMD) studies indicate 13% lower pooled, adjusted relative risks of cardiovascular events with every 1% improvement in FMD.
			*See additional comments: [https://www.sciencemediacentre.org/expert-reaction-to-the-vesuvius-study-comparing-the-cardiovascular-effects-of-smoking-and-vaping/ Science Media Centre]



	===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592370/ 2019: Electronic cigarettes and cardiovascular health: what do we know so far?]=== <!--T:15-->		===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592370/ 2019: Electronic cigarettes and cardiovascular health: what do we know so far?]=== <!--T:15-->

Richardpruen: /* Nicotine */ update links

2023-09-09T12:40:45Z

Nicotine: update links

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	===2017: Sympathomimetic Effects of Acute E‐Cigarette Use: Role of Nicotine and Non‐Nicotine Constituents=== <!--T:35-->		===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634299/#:~:text=In%20conclusion%2C%20the%20acute%20sympathomimetic,constituents%20in%20e%E2%80%90cigarette%20aerosol. Sympathomimetic Effects of Acute E‐Cigarette Use: Role of Nicotine and Non‐Nicotine Constituents]=== <!--T:35-->

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	===2016: Cardiovascular toxicity of nicotine: Implications for electronic cigarette use=== <!--T:37-->		===2016: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958544/#:~:text=Catecholamine%20release%20from%20nicotine%20could,fibrillation%20after%20experimental%20myocardial%20infarction. Cardiovascular toxicity of nicotine: Implications for electronic cigarette use]=== <!--T:37-->

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2023-06-16T00:30:14Z

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Richardpruen: /* 2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence */ update link

2023-06-07T10:46:33Z

2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence: update link

← Older revision		Revision as of 11:46, 7 June 2023
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	*Citation: Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H547-H556. doi: 10.1152/ajpheart.00307.2020. Epub 2020 Jul 31. PMID: 32734819; PMCID: PMC7509270.		*Citation: Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H547-H556. doi: 10.1152/ajpheart.00307.2020. Epub 2020 Jul 31. PMID: 32734819; PMCID: PMC7509270.

	===2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence=== <!--T:7-->		===2019: [https://gfn.events/documents/133/gfn_2018_reader.pdf Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence]=== <!--T:7-->

Richardpruen: Update links

2023-03-22T16:52:47Z

Update links

← Older revision		Revision as of 17:52, 22 March 2023
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	~~<!--T:10-->~~
	that debunks this study: Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health		that debunks this study: [https://onlinelibrary.wiley.com/doi/10.1111/add.15067 Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health]





	===2019: Is E-Cigarette Use associated with coronary heart disease and myocardial infarction?=== <!--T:11-->		===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767743/ 2019: Is E-Cigarette Use associated with coronary heart disease and myocardial infarction?]=== <!--T:11-->


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	===2019: (November 15) Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes=== <!--T:13-->		===[https://pubmed.ncbi.nlm.nih.gov/31740017/ 2019: (November 15) Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes]=== <!--T:13-->


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	===2019: Electronic cigarettes and cardiovascular health: what do we know so far?=== <!--T:15-->		===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592370/ 2019: Electronic cigarettes and cardiovascular health: what do we know so far?]=== <!--T:15-->

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	===2017: Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation (G2) and third-generation (G3) electronic cigarette users=== <!--T:17-->		===[https://pubmed.ncbi.nlm.nih.gov/27729564/ 2017: Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation (G2) and third-generation (G3) electronic cigarette users]=== <!--T:17-->

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	===2017: Electronic cigarette smoking increases of arterial stiffness and oxidative stress to a lesser extent than a single normal cigarette: an acute and chronic study=== <!--T:19-->		===[https://pubmed.ncbi.nlm.nih.gov/29335291/ 2017: Electronic cigarette smoking increases of arterial stiffness and oxidative stress to a lesser extent than a single normal cigarette: an acute and chronic study]=== <!--T:19-->

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	===2016: Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture=== <!--T:21-->		===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907307/ 2016: Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture]=== <!--T:21-->

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	===2013: Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report=== <!--T:23-->		===[https://pubmed.ncbi.nlm.nih.gov/23439796/ 2013: Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report]=== <!--T:23-->

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	===2012: Acute effects of electronic and tobacco cigarette smoking on complete blood count=== <!--T:25-->		===[https://pubmed.ncbi.nlm.nih.gov/22858449/ 2012: Acute effects of electronic and tobacco cigarette smoking on complete blood count]=== <!--T:25-->

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	===2010: A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: nicotine delivery profile and cardiovascular and subjective effects=== <!--T:27-->		===[https://pubmed.ncbi.nlm.nih.gov/20647410/ 2010: A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: nicotine delivery profile and cardiovascular and subjective effects]=== <!--T:27-->

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2022-12-30T11:31:07Z

adding content

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	*Citation: Ikonomidis, I., Katogiannis, K., Kostelli, G., Kourea, K., Kyriakou, E., Kypraiou, A., Tsoumani, M., Andreadou, I., Lambadiari, V., Plotas, P., Thymis, I., & Tsantes, A. E. (2020). Effects of electronic cigarette on platelet and vascular function after four months of use. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111389. https://doi.org/10.1016/j.fct.2020.111389		*Citation: Ikonomidis, I., Katogiannis, K., Kostelli, G., Kourea, K., Kyriakou, E., Kypraiou, A., Tsoumani, M., Andreadou, I., Lambadiari, V., Plotas, P., Thymis, I., & Tsantes, A. E. (2020). Effects of electronic cigarette on platelet and vascular function after four months of use. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111389. https://doi.org/10.1016/j.fct.2020.111389

	===2020: Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People=== ~~<!--T:5-->~~		===2020: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509270/ Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People]===
			*Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in tobacco cigarette (TC) smokers.
	~~<!--T:6-->~~		*Impaired FMD in TC smokers is most likely attributable to non-nicotine toxicants in TC smoke, since an equivalent increase in plasma nicotine from the EC did not lead to acute impairment in FMD.
	Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in tobacco cigarette (TC) smokers.		*FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose"(estimated plasma nicotine) of an e-cigarette (EC), consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment.
	FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose"(estimated plasma nicotine) of an e-cigarette (EC), consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment.		*However, there is increasing scientific literature that supports the notion that ECs, although not harmless, may be less harmful than TC smoking for cardiovascular risk.
			*Acknowledgement: This work was supported by Tobacco-Related Disease Research Program Grants TRDRP 23XT-0006H (to H.R.M.), 25IR-0024H (to H.R.M.), and TRDRP 28IR-0065 (H.R.M.) and by National Institutes of Health, National Center for Advancing Translational Science UCLA CTSI Grant UL1TR001881.
			*Citation: Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H547-H556. doi: 10.1152/ajpheart.00307.2020. Epub 2020 Jul 31. PMID: 32734819; PMCID: PMC7509270.


	===2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence=== <!--T:7-->		===2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence=== <!--T:7-->

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2022-12-30T11:11:41Z

adding content

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	===2020: Effects of electronic cigarette on platelet and vascular function after four months of use=== ~~<!--T:3-->~~		===2020: [https://www.sciencedirect.com/science/article/abs/pii/S0278691520302775 Effects of electronic cigarette on platelet and vascular function after four months of use]===
			*Electronic Cigarette vaping for four months has a neutral effect on platelet aggregation of healthy smokers. Continuation of tobacco cigarette smoking further deteriorates platelet function during 4 months of use.
	~~<!--T:4-->~~		*Electronic cigarette vaping improves arterial elastic properties and oxidative stress after 4 months of use. Tobacco cigarette smoking causes further impairment of arterial elasticity and oxidative stress during 4 months of use.
	Electronic Cigarette vaping for four months, has a neutral effect on platelet aggregation of healthy smokers.		*Citation: Ikonomidis, I., Katogiannis, K., Kostelli, G., Kourea, K., Kyriakou, E., Kypraiou, A., Tsoumani, M., Andreadou, I., Lambadiari, V., Plotas, P., Thymis, I., & Tsantes, A. E. (2020). Effects of electronic cigarette on platelet and vascular function after four months of use. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111389. https://doi.org/10.1016/j.fct.2020.111389
	Continuation of tobacco cigarette smoking further deteriorates platelet function during 4 months of use.
	Electronic cigarette vaping improves arterial elastic properties and oxidative stress after 4 months of use
	Tobacco cigarette smoking causes further impairment of arterial elasticity and oxidative stress during 4 months of use




	===2020: Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People=== <!--T:5-->		===2020: Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People=== <!--T:5-->

Skip at 23:06, 29 December 2022

2022-12-29T23:06:38Z

← Older revision		Revision as of 00:06, 30 December 2022
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	===[https://www.sciencedirect.com/science/article/pii/S0828282X21002518 Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers]=== <!--~~T:41~~-->		===2021: [https://www.sciencedirect.com/science/article/pii/S0828282X21002518 Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers]===
			*In this study, we showed that tobacco cigarette smoking, but not electronic-cigarette vaping, is associated with increased expression of major proteins in the toll-like receptor 4 (TLR4) inflammasome-interleukin (IL)-6 signalling axis in monocyte subtypes and T cells.
	<!--~~T:42~~-->		*These findings implicate the non-nicotine, pro-oxidant toxicants in tobacco cigarette smoke as instigators of increased expression of key proteins in the TLR4-inflammasome-IL-6 axis that contribute to atherogenesis.
	"proatherogenic" = promoting fatty plaques in the arteries (which is bad)		*These data support additional investigations into the role of ECIGs as part of a harm reduction strategy for adults addicted to TCIGs who are unwilling or unable to quit.
			*"proatherogenic" = promoting fatty plaques in the arteries (which is bad)
			*Acknowledgement: This work was supported by the Tobacco-Related Disease Research Program under the contract number TRDRP 28IR-0065 (H.R.M.), by Univeristy of California Office of the President under the contract number R00RG2749 Emergency COVID-19 Research Seed Funding (H.R.M.), and by the National Institutes of Health National Center for Advancing Translational Science University of California Los Angeles Clinical and Translational Science Institute grant number L1TR001881. This work was also supported in part by National Institutes of Health grants R01AG059501, R03AG059462 (T.K.). The flow cytometry machine used in the study was purchased through the University of California Los Angeles Center for AIDS Research (P30AI28697) grant.
			*Citation: Kelesidis, T., Zhang, Y., Tran, E., Sosa, G., & Middlekauff, H. R. (2021). Increased Expression of Proatherogenic Proteins in Immune Cell Subtypes in Tobacco Cigarette Smokers But Not in Electronic Cigarette Vapers. The Canadian journal of cardiology, 37(8), 1175–1180. https://doi.org/10.1016/j.cjca.2021.05.006

	=More Information= <!--T:43-->		=More Information= <!--T:43-->

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2021-11-25T15:44:53Z

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	=Suggested studies to add to this page= <!--T:40-->		=Suggested studies to add to this page= <!--T:40-->


			===2021: [https://www.mdpi.com/2079-7737/10/11/1208 Short-Term Cardiovascular Effects of E-Cigarettes in Adults Making a Stop-Smoking Attempt: A Randomized Controlled Trial]===

Richardpruen: Marked this version for translation

2021-11-18T15:43:47Z

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