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|h English (en)||*Smoking has a detrimental effect in [[Special:MyLanguage/Abbreviations|'''Crohn's disease (CD)''']], but this may be due to factors in smoking other than nicotine. Given that transdermal nicotine benefits [[Special:MyLanguage/Abbreviations|'''ulcerative colitis (UC)''']], and there is a considerable overlap in the treatment of UC and CD, the possible beneficial effect of nicotine has been examined in patients with Crohn's colitis.|
*In this relatively small study of patients with active Crohn's colitis, 6 mg nicotine enemas appeared to be of clinical benefit in most patients. They were well tolerated and safe.
*[http://downloads.hindawi.com/journals/grp/2008/237185.pdf PDF Version]
*Citation: J. R. Ingram, J. Rhodes, B. K. Evans, and G. A. O. Thomas, Hindawi Publishing Corporation, Gastroenterology Research and Practice, Volume 2008, Article ID 237185, 6 pages, doi:10.1155/2008/237185
*Acknowledgements: J. R. Ingram was supported by the Gastrointestinal Foundation Trust. SLA Pharma gave financial support to the project. The authors are indebted to Dr. J. T. Green (of Cardiff and Vale Hospitals Trust) who referred patients, and to Professor G. T. Williams (GTW) who performed all histological assessments.