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=How Mistakes Can Happen= | =How Mistakes Can Happen= | ||
===Blog: [https://rodutobaccotruth.blogspot.com/2024/04/are-vape-aerosols-really-toxic.html Are Vape Aerosols Really Toxic?]=== | |||
*Addresses several studies | |||
===2022: [https://reason.com/wp-content/uploads/2022/12/Rodu-Plurphanswat-CrossSec-Studies-IAEM-2022.pdf Cross‑sectional e‑cigarette studies are unreliable without timing of exposure and disease diagnosis]=== | ===2022: [https://reason.com/wp-content/uploads/2022/12/Rodu-Plurphanswat-CrossSec-Studies-IAEM-2022.pdf Cross‑sectional e‑cigarette studies are unreliable without timing of exposure and disease diagnosis]=== | ||
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*In summary, the results of Mantey et al. are invalid, because they were based on a definition of JUUL use that is not justified by the brand information in the 2020 National Youth Tobacco Survey.(Rodu) | *In summary, the results of Mantey et al. are invalid, because they were based on a definition of JUUL use that is not justified by the brand information in the 2020 National Youth Tobacco Survey.(Rodu) | ||
*Referring to: Mantey DS, Case KR, Omega-Njemnobi O, Springer AE, Kelder SH. Use frequency and symptoms of nicotine dependence among adolescent E-cigarette users: Comparison of JUUL and Non-JUUL users. Drug Alcohol Depend. 2021 Nov 1;228:109078. Epub 2021 Sep 24. PMID: 34614433; PMCID: PMC8595823. [https://doi.org/10.1016/j.drugalcdep.2021.109078 https://doi.org/10.1016/j.drugalcdep.2021.109078] | *Referring to: Mantey DS, Case KR, Omega-Njemnobi O, Springer AE, Kelder SH. Use frequency and symptoms of nicotine dependence among adolescent E-cigarette users: Comparison of JUUL and Non-JUUL users. Drug Alcohol Depend. 2021 Nov 1;228:109078. Epub 2021 Sep 24. PMID: 34614433; PMCID: PMC8595823. [https://doi.org/10.1016/j.drugalcdep.2021.109078 https://doi.org/10.1016/j.drugalcdep.2021.109078] | ||
===2019: Comments RE: [https://pubpeer.com/publications/1F7BA5A2DEC4EF71CA4E7F34C69806 Prevalence of vaping and smoking among adolescents in Canada, England, and the United States: repeat national cross sectional surveys]=== | |||
*These (improbable) increases conflict with official data from Statistics Canada that were released shortly after the publication of the paper drawn from the Canadian Community Health Survey, with a representative sample of 65,000. (Bates) | |||
*Referring to: Hammond D, Reid JL, Rynard VL, Fong GT, Cummings KM, McNeill A, Hitchman S, Thrasher JF, Goniewicz ML, Bansal-Travers M, O'Connor R, Levy D, Borland R, White CM. Prevalence of vaping and smoking among adolescents in Canada, England, and the United States: repeat national cross sectional surveys. BMJ. 2019 Jun 20;365:l2219. Erratum in: BMJ. 2020 Jul 10;370:m2579. PMID: 31221636; PMCID: PMC6582265. [https://doi.org/10.1136/bmj.l2219 doi: 10.1136/bmj.l2219] | |||
===2018: Comments RE: [https://pubpeer.com/publications/58B4D5D27C6A7C45EE3A094D324368 Prevalence and correlates of JUUL use among a national sample of youth and young adults]=== | ===2018: Comments RE: [https://pubpeer.com/publications/58B4D5D27C6A7C45EE3A094D324368 Prevalence and correlates of JUUL use among a national sample of youth and young adults]=== | ||
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*Referring to: Zhang Z, Jiao Z, Blaha MJ, Osei A, Sidhaye V, Ramanathan M Jr, Biswal S. The Association Between E-Cigarette Use and Prediabetes: Results From the Behavioral Risk Factor Surveillance System, 2016-2018. Am J Prev Med. 2022 Jun;62(6):872-877. [https://www.ajpmonline.org/article/S0749-3797(22)00024-1/fulltext doi: 10.1016/j.amepre.2021.12.009]. Epub 2022 Mar 3. PMID: 35597566. | *Referring to: Zhang Z, Jiao Z, Blaha MJ, Osei A, Sidhaye V, Ramanathan M Jr, Biswal S. The Association Between E-Cigarette Use and Prediabetes: Results From the Behavioral Risk Factor Surveillance System, 2016-2018. Am J Prev Med. 2022 Jun;62(6):872-877. [https://www.ajpmonline.org/article/S0749-3797(22)00024-1/fulltext doi: 10.1016/j.amepre.2021.12.009]. Epub 2022 Mar 3. PMID: 35597566. | ||
==EVALI ( | ==EVALI== | ||
===2022: Comments RE: [https://pubpeer.com/publications/053A4DD87764E36C0B9FF00B260480 Discussions of Flavored ENDS Sales Restrictions: Themes Related to Circumventing Policies on Reddit]=== | |||
*This article incorrectly states, “In the wake of the e-cigarette or vaping use-related lung injury (EVALI) outbreak in September 2019, electronic cigarette manufacturer JUUL voluntarily removed flavored pods aside from tobacco and menthol from the U.S. market” That sentence is false and creates a factually inaccurate and damaging link in a reader’s mind between JUUL products and the 2019 lung injuries (EVALI) when none exists. In fact, Juul Labs reduced its flavor portfolio to tobacco and menthol to combat underage use and the ingredients of JUUL products do not include vitamin E compounds or THC that were primarily linked to EVALI. (Murillo) | |||
*Referring to: Silver N, Kucherlapaty P, Kostygina G, Tran H, Feng M, Emery S, Schillo B. Discussions of Flavored ENDS Sales Restrictions: Themes Related to Circumventing Policies on Reddit. Int J Environ Res Public Health. 2022 Jun 23;19(13):7668. PMID: 35805325; PMCID: PMC9266029. [https://doi.org/10.3390/ijerph19137668 doi: 10.3390/ijerph19137668] | |||
==Flavors== | ==Flavors== | ||
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*The PubPeer entry from Juul Labs Inc. (JLI) raises a number of serious questions about this research, the research conduct of the authors, and the editorial practices of the journal. (Bates) | *The PubPeer entry from Juul Labs Inc. (JLI) raises a number of serious questions about this research, the research conduct of the authors, and the editorial practices of the journal. (Bates) | ||
*Referring To: Yassine A, El Hage R, El-Hellani A, et al. Levels of menthol, nicotine, and cooling agents measured in JUUL products purchased across a three-year period Tobacco Control 2022;31:s234-s237. [https://doi.org/10.1136/tc-2022-057506 https://doi.org/10.1136/tc-2022-057506] | *Referring To: Yassine A, El Hage R, El-Hellani A, et al. Levels of menthol, nicotine, and cooling agents measured in JUUL products purchased across a three-year period Tobacco Control 2022;31:s234-s237. [https://doi.org/10.1136/tc-2022-057506 https://doi.org/10.1136/tc-2022-057506] | ||
===2022: Comments RE: [https://pubpeer.com/publications/053A4DD87764E36C0B9FF00B260480 Discussions of Flavored ENDS Sales Restrictions: Themes Related to Circumventing Policies on Reddit]=== | |||
*This article incorrectly states, “In the wake of the e-cigarette or vaping use-related lung injury (EVALI) outbreak in September 2019, electronic cigarette manufacturer JUUL voluntarily removed flavored pods aside from tobacco and menthol from the U.S. market” That sentence is false and creates a factually inaccurate and damaging link in a reader’s mind between JUUL products and the 2019 lung injuries (EVALI) when none exists. In fact, Juul Labs reduced its flavor portfolio to tobacco and menthol to combat underage use and the ingredients of JUUL products do not include vitamin E compounds or THC that were primarily linked to EVALI. (Murillo) | |||
*Referring to: Silver N, Kucherlapaty P, Kostygina G, Tran H, Feng M, Emery S, Schillo B. Discussions of Flavored ENDS Sales Restrictions: Themes Related to Circumventing Policies on Reddit. Int J Environ Res Public Health. 2022 Jun 23;19(13):7668. PMID: 35805325; PMCID: PMC9266029. [https://doi.org/10.3390/ijerph19137668 doi: 10.3390/ijerph19137668] | |||
==Gateway== | ==Gateway== | ||
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===2024: Comments RE: [https://www.ecigarette-research.org/research/index.php/research/2024/281-ecig-disease Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes]=== | ===2024: Comments RE: [https://www.ecigarette-research.org/research/index.php/research/2024/281-ecig-disease Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes]=== | ||
*"The study provides zero evidence on any risk associated with e-cigarette use, whether absolute risk or in comparison with smoking. The question that was supposed to be addressed in this metanalysis CANNOT be examined with the studies included in their analysis." (Farsalinos) | *"The study provides zero evidence on any risk associated with e-cigarette use, whether absolute risk or in comparison with smoking. The question that was supposed to be addressed in this metanalysis CANNOT be examined with the studies included in their analysis." (Farsalinos) | ||
*Referring to: Glantz SA, Nguyen N, Oliveira da Silva AL. Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes. NEJM Evid. 2024 Mar;3(3):EVIDoa2300229. [https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300229 doi: 10.1056/EVIDoa2300229] | *Referring to: Glantz SA, Nguyen N, Oliveira da Silva AL. Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes. NEJM Evid. 2024 Mar;3(3):EVIDoa2300229. Epub 2024 Feb 27. PMID: 38411454. [https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300229 doi: 10.1056/EVIDoa2300229] | ||
===2022: Comments RE: [https://colinmendelsohn.com.au/wp-content/uploads/2022/07/Mendelsohn-Wodak-Hall-Borland.-A-critical-analysis-of-Ecigs-and-health-outcomes-systematic-review-of-global-evidence.-DAR-2022.pdf Electronic cigarettes and health outcomes: systematic review of global evidence]=== | ===2022: Comments RE: [https://colinmendelsohn.com.au/wp-content/uploads/2022/07/Mendelsohn-Wodak-Hall-Borland.-A-critical-analysis-of-Ecigs-and-health-outcomes-systematic-review-of-global-evidence.-DAR-2022.pdf Electronic cigarettes and health outcomes: systematic review of global evidence]=== | ||
*Contrary to the conclusions of the Banks review, the evidence suggests that vaping nicotine is an effective smoking cessation aid; that vaping is substantially less harmful than smoking tobacco; that vaping is diverting young people away from smoking; and that vaping by smokers is likely to have a major net public health benefit if widely available to adult Australian smokers. (Mendelsohn) | *Contrary to the conclusions of the Banks review, the evidence suggests that vaping nicotine is an effective smoking cessation aid; that vaping is substantially less harmful than smoking tobacco; that vaping is diverting young people away from smoking; and that vaping by smokers is likely to have a major net public health benefit if widely available to adult Australian smokers. (Mendelsohn) | ||
*Referring to: Banks E, Yazidjoglou A, Brown S, Nguyen M, Martin M, Beckwith K, Daluwatta A, Campbell S, Joshy G. [https://www.nhmrc.gov.au/sites/default/files/documents/attachments/ecigarettes/Electronic_cigarettes_and_health_outcomes_%20systematic_review_of_evidence.pdf Electronic cigarettes and health outcomes: systematic review of global evidence]. Report for the Australian Department of Health. National Centre for Epidemiology and Population Health, Canberra: April 2022. | *Referring to: Banks E, Yazidjoglou A, Brown S, Nguyen M, Martin M, Beckwith K, Daluwatta A, Campbell S, Joshy G. [https://www.nhmrc.gov.au/sites/default/files/documents/attachments/ecigarettes/Electronic_cigarettes_and_health_outcomes_%20systematic_review_of_evidence.pdf Electronic cigarettes and health outcomes: systematic review of global evidence]. Report for the Australian Department of Health. National Centre for Epidemiology and Population Health, Canberra: April 2022. | ||
===2022: Comments RE: [https://pubpeer.com/publications/727EA7B64FB27270F20717729D7629 Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice]=== | |||
*Although this new research from Moshensky et al., does add to the scientific literature about previously marketed JUUL products, we believe the conclusions presented in the manuscript are not adequately supported by the study data. In addition, the lack of quantitative data on actual dosing limits the ability to establish relevance to potential human exposures from product use. Furthermore, the lack of a comparison against the effects of tobacco smoke limits the ability to evaluate these study findings in the context of the tobacco product risk continuum, and risk relative to use of combusted cigarettes. (Weil) | |||
*Referring to: Moshensky A, Brand CS, Alhaddad H, Shin J, Masso-Silva JA, Advani I, Gunge D, Sharma A, Mehta S, Jahan A, Nilaad S, Olay J, Gu W, Simonson T, Almarghalani D, Pham J, Perera S, Park K, Al-Kolla R, Moon H, Das S, Byun MK, Shah Z, Sari Y, Heller Brown J, Crotty Alexander LE. Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. Elife. 2022 Apr 12;11:e67621. PMID: 35411847; PMCID: PMC9005188. [https://doi.org/10.7554/elife.67621 doi: 10.7554/eLife.67621] | |||
==Respiratory== | ==Respiratory== | ||
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=Suggestions to add to this page= | =Suggestions to add to this page= | ||
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==Paper: [https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.29148 Downregulation of miR-218 by nicotine promotes cell proliferation through targeting CDK6 in non–small cell lung cancer]== | |||
*[https://pubmed.ncbi.nlm.nih.gov/38577886/ Retraction] | |||
*[https://pubpeer.com/publications/D500DE74010B291A7B27CBB9083FEA PubPeer] | |||
==Paper: [https://pubs.acs.org/doi/10.1021/acs.chemrestox.1c00253 Characterizing the Chemical Landscape in Commercial E-Cigarette Liquids and Aerosols by Liquid Chromatography–High-Resolution Mass Spectrometry]== | ==Paper: [https://pubs.acs.org/doi/10.1021/acs.chemrestox.1c00253 Characterizing the Chemical Landscape in Commercial E-Cigarette Liquids and Aerosols by Liquid Chromatography–High-Resolution Mass Spectrometry]== | ||
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==Paper: [https://gh.bmj.com/content/9/2/e013866 Pharmaceuticalisation as the tobacco industry’s endgame]== | ==Paper: [https://gh.bmj.com/content/9/2/e013866 Pharmaceuticalisation as the tobacco industry’s endgame]== | ||
*Comment: [https://pubpeer.com/publications/374B1C6D333BD84814E878DF9D1611 Title: Errors in one sentence - oversights or indicators of other problems?] | *Comment: [https://pubpeer.com/publications/374B1C6D333BD84814E878DF9D1611 Title: Errors in one sentence - oversights or indicators of other problems?] | ||
==[https://www.ecigarette-research.org/research/index.php/whats-new/whatsnew-2015/233-pm A new study reports that e-cigarettes emit toxins to the environment but the authors did not really find any…]== | |||
<br> | <br> | ||
[[File:Retracted 2.png|center|]] | [[File:Retracted 2.png|center|]] | ||
edits