Smokeless Tobacco - HnB: Difference between revisions

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HnB = Heat not Burn

HTP = Heated Tobacco Product

THP = Tobacco Heating Product

'''Studies, Surveys, Papers, and Case Studies'''

*Sometimes it's necessary to view the PDF version to access the full study.

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=Suggested studies to add to this page=

===2024: [https://tobaccocontrol.bmj.com/content/early/2024/06/13/tc-2024-058635 Switching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence relief]===

*Conclusions: "IQOS fully substituted for cigarettes in ~20% of people who were not immediately interested in quitting smoking while the remainder significantly reduced their smoking. Positive reinforcing effects of IQOS foster use and the transition away from combustible cigarettes."

**Citation: Audrain-McGovern J, Wileyto EP, Klapec O, et alSwitching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence reliefTobacco Control Published Online First: 13 June 2024. doi: 10.1136/tc-2024-058635

=== 2023: [https://chemrxiv.org/engage/chemrxiv/article-details/64bfeab3ae3d1a7b0d52ddbb Aerosol emissions from Heated Tobacco Products: a review focusing on carbonyls, analytical methods and experimental quality] ===

* Roberto A. Sussman, Federica Sipala, Rosalia Emma, Simone Ronsisvalle (Pre-print)

* We provide an extensive review of 17 independent and industry-funded studies targeting carbonyls in aerosol emissions of Heated Tobacco Products (HTPs), focusing on quality criteria based on the reproducibility of experiments, appropriate analytic methods, and puffing regimes. Most revised studies complied with these requirements, but some were unreproducible, while others failed to consider analytical variables that may have affected the results and/or produced unrealistic comparisons.

* We also provide a review of the literature on physicochemical properties of heated tobacco and HTP aerosols, as well as the evaluation of HTPs by regulatory agencies, addressing various critiques of their relative safety profile.

* The outcomes from the revised studies and regulatory evaluations tend to agree with and converge to a general consensus that HTP aerosols expose users to significantly lower levels of toxicity than tobacco smoke.

===[https://twitter.com/ManuelPeitsch/status/1380128227973341189 Twitter thread with HnB info]===

=== 2023: [https://pubmed.ncbi.nlm.nih.gov/37014673/ Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial] ===

* ''Switching to HTPs elicited a marked reduction in cigarette consumption among '''people who smoke and do not intend to quit''', which was comparable to refillable ECs. User experience and risk perception were similar between the HTPs and ECs under investigation. HTPs may be a useful addition to the arsenal of reduced-risk alternatives for tobacco cigarettes and may contribute to smoking cessation. However, longer follow-up studies are required to confirm significant and prolonged abstinence from smoking and to determine whether our results can be generalized outside smoking cessation services offering high levels of support.''

* There is no right or ideal product - it's the one people want to use instead of cigarettes at the time, and in the situation, they want to use it.<br />

===2021 [https://link.springer.com/article/10.1007/s11739-021-02798-6 Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial]===

===2021 [https://www.sciencedirect.com/science/article/pii/S2214750021000147 Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco products]===

===2021 [https://www.sciencedirect.com/science/article/abs/pii/S0304389420314060 Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===

===2020 [https://www.sciencedirect.com/science/article/pii/S0304389420314060?via%3Dihub Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===

*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes.

*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours.

*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours (vapors).

*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress.

*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig.

*[https://sci-hub.se/10.1016/j.jhazmat.2020.123417 PDF Version]

*Citation: Dusautoir R, Zarcone G, Verriele M, Garc¸on G, Fronval I, Beauval N, Allorge D, Riffault V, Locoge N, Lo-Guidice J-Marc, Antherieu S, Comparison of the ´ chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials (2020), doi: 10.1016/j.jhazmat.2020.123417

*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648.

===2018 [https://pubmed.ncbi.nlm.nih.gov/29920842/ Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette]===

*The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette.

*[https://sci-hub.se/10.1111/add.14365 PDF Version]

*Citation: Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette. Addiction. 2018 Nov;113(11):2099-2106. doi: 10.1111/add.14365. Epub 2018 Jul 10. PMID: 29920842.

*Keywords: Carbonyls; electronic cigarettes; harm reduction; heated tobacco products; nicotine; smoking.

=More Information=

*Click on the category link below for more studies by topic on Smokeless Tobacco and Nicotine.

[[Category:Studies, Surveys, and Papers]]

@@ Line 1: / Line 1: @@
+HnB = Heat not Burn
+HTP = Heated Tobacco Product
+THP = Tobacco Heating Product
 '''Studies, Surveys, Papers, and Case Studies'''
 *Sometimes it's necessary to view the PDF version to access the full study.
@@ Line 18: / Line 22: @@
 =Suggested studies to add to this page=
+===2024: [https://tobaccocontrol.bmj.com/content/early/2024/06/13/tc-2024-058635 Switching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence relief]===
+*Conclusions: "IQOS fully substituted for cigarettes in ~20% of people who were not immediately interested in quitting smoking while the remainder significantly reduced their smoking. Positive reinforcing effects of IQOS foster use and the transition away from combustible cigarettes."
+**Citation: Audrain-McGovern J, Wileyto EP, Klapec O, et alSwitching from cigarettes to IQOS: the relative importance of IQOS-associated reward, reinforcement and abstinence reliefTobacco Control Published Online First: 13 June 2024. doi: 10.1136/tc-2024-058635
+=== 2023: [https://chemrxiv.org/engage/chemrxiv/article-details/64bfeab3ae3d1a7b0d52ddbb Aerosol emissions from Heated Tobacco Products: a review focusing on carbonyls, analytical methods and experimental quality] ===
+* Roberto A. Sussman, Federica Sipala, Rosalia Emma, Simone Ronsisvalle (Pre-print)
+* We provide an extensive review of 17 independent and industry-funded studies targeting carbonyls in aerosol emissions of Heated Tobacco Products (HTPs), focusing on quality criteria based on the reproducibility of experiments, appropriate analytic methods, and puffing regimes. Most revised studies complied with these requirements, but some were unreproducible, while others failed to consider analytical variables that may have affected the results and/or produced unrealistic comparisons.
+* We also provide a review of the literature on physicochemical properties of heated tobacco and HTP aerosols, as well as the evaluation of HTPs by regulatory agencies, addressing various critiques of their relative safety profile.
+* The outcomes from the revised studies and regulatory evaluations tend to agree with and converge to a general consensus that HTP aerosols expose users to significantly lower levels of toxicity than tobacco smoke.
+===[https://twitter.com/ManuelPeitsch/status/1380128227973341189 Twitter thread with HnB info]===
+=== 2023: [https://pubmed.ncbi.nlm.nih.gov/37014673/ Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial] ===
+* ''Switching to HTPs elicited a marked reduction in cigarette consumption among '''people who smoke and do not intend to quit''', which was comparable to refillable ECs. User experience and risk perception were similar between the HTPs and ECs under investigation. HTPs may be a useful addition to the arsenal of reduced-risk alternatives for tobacco cigarettes and may contribute to smoking cessation. However, longer follow-up studies are required to confirm significant and prolonged abstinence from smoking and to determine whether our results can be generalized outside smoking cessation services offering high levels of support.''
+* There is no right or ideal product - it's the one people want to use instead of cigarettes at the time, and in the situation, they want to use it.<br />
+===2021 [https://link.springer.com/article/10.1007/s11739-021-02798-6 Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial]===
+===2021 [https://www.sciencedirect.com/science/article/pii/S2214750021000147 Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco products]===
+===2021 [https://www.sciencedirect.com/science/article/abs/pii/S0304389420314060 Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===
+===2020 [https://www.sciencedirect.com/science/article/pii/S0304389420314060?via%3Dihub Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===
+*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes.
+*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours.
+*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours (vapors).
+*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress.
+*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig.
+*[https://sci-hub.se/10.1016/j.jhazmat.2020.123417 PDF Version]
+*Citation:  Dusautoir R, Zarcone G, Verriele M, Garc¸on G, Fronval I, Beauval N, Allorge D, Riffault V, Locoge N, Lo-Guidice J-Marc, Antherieu S, Comparison of the ´ chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials (2020), doi: 10.1016/j.jhazmat.2020.123417
+*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648.
+===2018 [https://pubmed.ncbi.nlm.nih.gov/29920842/ Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette]===
+*The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette.
+*[https://sci-hub.se/10.1111/add.14365 PDF Version]
+*Citation: Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette. Addiction. 2018 Nov;113(11):2099-2106. doi: 10.1111/add.14365. Epub 2018 Jul 10. PMID: 29920842.
+*Keywords: Carbonyls; electronic cigarettes; harm reduction; heated tobacco products; nicotine; smoking.
 =More Information=
 *Click on the category link below for more studies by topic on Smokeless Tobacco and Nicotine.
 [[Category:Studies, Surveys, and Papers]]