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*Some early evidence suggests that e-cigarettes may help some smokers reduce or quit combustible tobacco use. | *Some early evidence suggests that e-cigarettes may help some smokers reduce or quit combustible tobacco use. | ||
*[https://sci-hub.se/10.3322/caac.21455 PDF Version] | *[https://sci-hub.se/10.3322/caac.21455 PDF Version] | ||
===2018 [https://pubmed.ncbi.nlm.nih.gov/29920842/ Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette]=== | |||
*The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette. | |||
*[https://sci-hub.se/10.1111/add.14365 PDF Version] | |||
*Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette. Addiction. 2018 Nov;113(11):2099-2106. doi: 10.1111/add.14365. Epub 2018 Jul 10. PMID: 29920842. | |||
*Keywords: Carbonyls; electronic cigarettes; harm reduction; heated tobacco products; nicotine; smoking. | |||
===2018 [http://www.fontemscience.com/wp-content/uploads/2018/06/2018-04-18-aerosol-chemistry-thr-summit-2018-poster_final.pdf Chemical Composition of myblu™ Pod-System E-Cigarette Aerosols: A Quantitative Comparison with Conventional Cigarette Smoke]=== | |||
*Of the 51 toxicants tested, eight were detected in the e-cigarette aerosols but at substantially lower levels than reported in cigarette smoke. | |||
*Link above to the PDF form of the information presented at: 1st Scientific Summit, Tobacco Harm Reduction, Kallithea, Greece, June 2018 | |||
*Citation: Grant O’Connell1, Tanvir Walele1, Chris Prue1, Gene Gillman, Xavier Cahours, Olivia Hibbert & John D. Pritchard | |||
*Acknowledgement: This work was supported by Fontem Ventures B.V. Imperial Brands plc is the parent company of Fontem Ventures B.V., the manufacturer of the e-cigarette products used in this study. | |||
===2018 [https://www.sciencedirect.com/science/article/abs/pii/S0021850217301155 Measurements of electronic cigarette-generated particles for the evaluation of lung cancer risk of active and passive users]=== | |||
*In this study, we have demonstrated that no clinically relevant, product-related safety findings were observed for smokers of Combustible Cigarettes (CC) switching to an [[Abbreviations|Electronic Vapor Product (EVP)]] for 12 weeks under real-life settings. Adverse Effects (AEs) reported by subjects switching to the EVP occurred primarily within the first week after switching, and only 1.3% of all AEs reported were considered to be almost definitely related to the product. Up to a third of all reported AEs in the EVP group were related to nicotine withdrawal symptoms, which were observed to decrease after the first two weeks from product switch. EVP use was associated with significant decreases in exposure to nicotine and other chemicals such as benzene and acrolein, typically found in CC smoke. Changes were also observed in the level of WBC, haemoglobin, RBC and LDL cholesterol, which although minor, were consistent with those observed after smoking cessation. The data presented in this study shows the potential that EVPs may offer to smokers looking for an alternative to CCs. | |||
*[https://sci-hub.se/10.1016/j.jaerosci.2017.10.006 PDF Version] | |||
*Citation: Mauro Scungio, Luca Stabile, Giorgio Buonanno, Measurements of electronic cigarette-generated particles for the evaluation of lung cancer risk of active and passive users, Journal of Aerosol Science, Volume 115, 2018, Pages 1-11, ISSN 0021-8502, doi:10.1016/j.jaerosci.2017.10.006. | |||
*Keywords: E-cigs: Electronic cigarettesUltrafine particlesELCRLung cancer risk | |||
===2018 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324349/ Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes]=== | |||
*In this population-based cohort study of 5105 participants, current exclusive e-cigarette users had greater concentrations of biomarkers of nicotine, tobacco-specific nitrosamines, volatile organic compounds, and metals compared with never tobacco users. However, these concentrations were lower than those observed in current exclusive cigarette smokers and dual users of both products. | |||
*[https://documentcloud.adobe.com/link/track?uri=urn%3Aaaid%3Ascds%3AUS%3A0923e7cd-7d55-45fc-923e-4ad06343a73e#pageNum=1 PDF Version] | |||
*Citation: Goniewicz ML, Smith DM, Edwards KC, Blount BC, Caldwell KL, Feng J, Wang L, Christensen C, Ambrose B, Borek N, van Bemmel D, Konkel K, Erives G, Stanton CA, Lambert E, Kimmel HL, Hatsukami D, Hecht SS, Niaura RS, Travers M, Lawrence C, Hyland AJ. Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes. JAMA Netw Open. 2018 Dec 7;1(8):e185937. doi: 10.1001/jamanetworkopen.2018.5937. PMID: 30646298; PMCID: PMC6324349. | |||
===2018 [https://www.nap.edu/read/24952/chapter/1 Public Health Consequences of E-Cigarettes]=== | |||
*There is conclusive evidence that completely substituting e-cigarettes for combustible tobacco cigarettes reduces users’ exposure to numerous toxicants and carcinogens present in combustible tobacco cigarettes. | |||
*There is substantial evidence that except for nicotine, under typical conditions of use, exposure to potentially toxic substances from e-cigarettes is significantly lower compared with combustible tobacco cigarettes. | |||
*There is substantial evidence that completely switching from regular use of combustible tobacco cigarettes to e-cigarettes results in reduced short-term adverse health outcomes in several organ systems. | |||
*There is moderate evidence that risk and severity of dependence are lower for e-cigarettes than combustible tobacco cigarettes. | |||
*There is moderate evidence from randomized controlled trials that e-cigarettes with nicotine are more effective than e-cigarettes without nicotine for smoking cessation. | |||
*While the overall evidence from observational trials is mixed, there is moderate evidence from observational studies that more frequent use of e-cigarettes is associated with an increased likelihood of cessation. | |||
*There is moderate evidence that second-hand exposure to nicotine and particulates is lower from e-cigarettes compared with combustible tobacco cigarettes. | |||
*There is limited evidence for improvement in lung function and respiratory symptoms among adult smokers with asthma who switch to e-cigarettes completely or in part (dual use). | |||
*There is limited evidence for reduction of chronic obstructive pulmonary disease (COPD) exacerbations among adult smokers with COPD who switch to e-cigarettes completely or in part (dual use). | |||
*There is limited evidence suggesting that switching to e-cigarettes will improve periodontal disease in smokers. | |||
*Link above is to the PDF of 750 page report | |||
*Citation: National Academies of Sciences, Engineering, and Medicine. 2018. Public Health Consequences of E-Cigarettes. Washington, DC: The National Academies Press. doi:10.17226/24952. | |||
==ENDS (without comparison to other products)== | ==ENDS (without comparison to other products)== | ||
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