Nicotine therapeutic benefits: Difference between revisions

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===2023: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602090/ Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture]===

*Preprint, not peer-reviewed.

*In summary, our results not only support neuroprotective effects of nicotine and butyrate in countering Fe and Mn toxicities but indicate a synergistic protection by combination of the two. Moreover, distinct mechanisms of action for each metal, i.e., nicotinic receptor for nicotine and FA3R for butyrate are indicated. Further exploitation of mechanisms of action of butyrate and nicotine may provide novel targets for metal toxicities and/or amelioration of neurodegenerative diseases.

*Citation: Tizabi Y, Getachew B, Aschner M. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3389904. doi: 10.21203/rs.3.rs-3389904/v1. Update in: Neurotox Res. 2023 Dec 14;42(1):3. doi: 10.1007/s12640-023-00682-z. PMID: 37886507; PMCID: PMC10602090.

**Citation: Tizabi Y, Getachew B, Aschner M. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3389904. doi: 10.21203/rs.3.rs-3389904/v1. Update in: Neurotox Res. 2023 Dec 14;42(1):3. doi: 10.1007/s12640-023-00682-z. PMID: 37886507; PMCID: PMC10602090.

***Acknowledgement: Supported in part by: NIH/NIAAA R03 AA022479 and NIH/NIGMS (2 SO6 GM08016‐39) (YT), and NIEHS R01ES10563 and R01ES07331 (MA).

=== 2020: [https://n.neurology.org/content/94/20/e2132 Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors] ===

@@ Line 1,127: / Line 1,127: @@
 ===2023: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602090/ Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture]===
+*Preprint, not peer-reviewed.
 *In summary, our results not only support neuroprotective effects of nicotine and butyrate in countering Fe and Mn toxicities but indicate a synergistic protection by combination of the two. Moreover, distinct mechanisms of action for each metal, i.e., nicotinic receptor for nicotine and FA3R for butyrate are indicated. Further exploitation of mechanisms of action of butyrate and nicotine may provide novel targets for metal toxicities and/or amelioration of neurodegenerative diseases.
-*Citation: Tizabi Y, Getachew B, Aschner M. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3389904. doi: 10.21203/rs.3.rs-3389904/v1. Update in: Neurotox Res. 2023 Dec 14;42(1):3. doi: 10.1007/s12640-023-00682-z. PMID: 37886507; PMCID: PMC10602090.
+**Citation: Tizabi Y, Getachew B, Aschner M. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3389904. doi: 10.21203/rs.3.rs-3389904/v1. Update in: Neurotox Res. 2023 Dec 14;42(1):3. doi: 10.1007/s12640-023-00682-z. PMID: 37886507; PMCID: PMC10602090.
+***Acknowledgement: Supported in part by: NIH/NIAAA R03 AA022479 and NIH/NIGMS (2 SO6 GM08016‐39) (YT), and NIEHS R01ES10563 and R01ES07331 (MA).
 === 2020: [https://n.neurology.org/content/94/20/e2132 Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors] ===