ENDS Toxicity / Carcinogenic: Difference between revisions

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==Flavoring in ENDS Products==

===2019 [https://www.sciencedirect.com/science/article/pii/S0887233318307768?via%3Dihub High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate]===

*Our results clearly show a lower toxicity of e-liquids, including flavoured e-liquids, when compared to CSC (cigarette smoke condensate). Typically, more than 100 times higher concentrations of CFs (Base liquids, with or without nicotine, and commercial, flavoured, nicotine-containing e-liquids) are required to elicit the same response as those observed for 3R4F CSC in specific endpoints.

*Flavours play a critical role in attracting, and retaining smokers to e-cigarettes.

*[https://sci-hub.st/10.1016/j.tiv.2019.03.018 PDF Version]

*Citation: Lukasz Czekala, Liam Simms, Matthew Stevenson, Edgar Trelles-Sticken, Paul Walker, Tanvir Walele, High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate, Toxicology in Vitro, Volume 58, 2019, Pages 86-96, ISSN 0887-2333, doi:10.1016/j.tiv.2019.03.018.

*Acknowledgements: This work was funded and supported by Fontem Ventures B.V., part of Imperial Brands Group PLC.

* Keywords: Flavours, In vitro, Normal Human Bronchial Epithelial cells, High Content Screening, E-liquids, Cigarette

===2019 [https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0318-2?optIn=false Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study]===

*The vast majority of flavouring (flavoring) compounds in e-cigarette liquids as reported in a recent study were present at levels far lower than needed to classify them as toxic.

*[https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-019-0318-2.pdf PDF Version]

*Farsalinos, K., Lagoumintzis, G. Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study. Harm Reduct J 16, 48 (2019). doi: 10.1186/s12954-019-0318-2

*Acknowledgements: The authors report no conflict of interest for the past 36 months. For the past 60 months, KF has published 2 studies funded by the non-profit association AEMSA and 1 study funded by the non-profit association Tennessee Smoke-Free Association.

==Other ENDS Liquids Ingredients (PG/VG/Nicotine)==

@@ Line 24: / Line 24: @@
 ==Flavoring in ENDS Products==
+===2019 [https://www.sciencedirect.com/science/article/pii/S0887233318307768?via%3Dihub High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate]===
+*Our results clearly show a lower toxicity of e-liquids, including flavoured e-liquids, when compared to CSC (cigarette smoke condensate). Typically, more than 100 times higher concentrations of CFs (Base liquids, with or without nicotine, and commercial, flavoured, nicotine-containing e-liquids) are required to elicit the same response as those observed for 3R4F CSC in specific endpoints.
+*Flavours play a critical role in attracting, and retaining smokers to e-cigarettes.
+*[https://sci-hub.st/10.1016/j.tiv.2019.03.018 PDF Version]
+*Citation: Lukasz Czekala, Liam Simms, Matthew Stevenson, Edgar Trelles-Sticken, Paul Walker, Tanvir Walele, High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate, Toxicology in Vitro, Volume 58, 2019, Pages 86-96, ISSN 0887-2333, doi:10.1016/j.tiv.2019.03.018.
+*Acknowledgements: This work was funded and supported by Fontem Ventures B.V., part of Imperial Brands Group PLC.
+* Keywords: Flavours, In vitro, Normal Human Bronchial Epithelial cells, High Content Screening, E-liquids, Cigarette
+===2019 [https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0318-2?optIn=false Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study]===
+*The vast majority of flavouring (flavoring) compounds in e-cigarette liquids as reported in a recent study were present at levels far lower than needed to classify them as toxic.
+*[https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-019-0318-2.pdf PDF Version]
+*Farsalinos, K., Lagoumintzis, G. Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study. Harm Reduct J 16, 48 (2019). doi: 10.1186/s12954-019-0318-2
+*Acknowledgements: The authors report no conflict of interest for the past 36 months. For the past 60 months, KF has published 2 studies funded by the non-profit association AEMSA and 1 study funded by the non-profit association Tennessee Smoke-Free Association.
 ==Other ENDS Liquids Ingredients (PG/VG/Nicotine)==