Nicotine therapeutic benefits: Difference between revisions

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***Acknowledgement: Financial support: Academic Medical Center, Amsterdam, The Netherlands. Potential conflicts of interest: K.J.T. is cofounder of Critical Therapeutics Inc., a pharmaceutical company developing potential future treatment modalities based on the cholinergic anti-inflammatory pathway.

='''Sleep ~~Apnea~~'''=

='''Sleep'''=

===1991 [https://pubmed.ncbi.nlm.nih.gov/1859921/ Beneficial effects of nicotine]===

==Apnea==

===1991: [https://pubmed.ncbi.nlm.nih.gov/1859921/ Beneficial effects of nicotine]===

*When chronically taken, nicotine may result in: protection against sleep apnea (other diseases / issues mentioned in study)

*[https://sci-hub.st/10.1111/j.1360-0443.1991.tb01810.x PDF Version]

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*[https://sci-hub.se/10.1378/chest.87.1.11 PDF Version]

**Citation: Gothe B, Strohl KP, Levin S, Cherniack NS. Nicotine: a different approach to treatment of obstructive sleep apnea. Chest. 1985 Jan;87(1):11-7. doi: 10.1378/chest.87.1.11. PMID: 3965253.

***Acknowledgement: None found

==REM==

===2017: [https://onlinelibrary.wiley.com/doi/10.1002/brb3.704 Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus]===

*Animal study

*MWM test found that REM sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM protein expression in CA1, CA2, CA3, and DG regions and the mean relative level of DREAM protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM protein.

**Citation: Abd Rashid N, Hapidin H, Abdullah H, Ismail Z, Long I. Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus. Brain Behav. 2017; 7:e00704. https://doi.org/10.1002/brb3.704

***Acknowledgement: This study was supported by the Universiti Sains Malaysia (USM) Short-Term Grant Scheme (304/PPSK/61312093), USM Research University grants (RUI) (1001/PPSK/812139) and Fundamental Research Grant Scheme (FRGS) (203/PPSK/6171153).

===2011: [https://onlinelibrary.wiley.com/doi/10.1002/hipo.20806 Acute nicotine treatment prevents rem sleep deprivation-induced learning and memory impairment in rat]===

*Animal Study

*However, concurrent, acute treatment of rats with nicotine significantly attenuated SD-induced impairment of learning and STM and prevented SD-induced impairment of LTP in the CA1 and DG regions. These results show that acute nicotine treatment prevented the deleterious effect of sleep loss on cognitive abilities and synaptic plasticity.

*[https://www.academia.edu/18461315/Acute_nicotine_treatment_prevents_REM_sleep_deprivation_induced_learning_and_memory_impairment_in_rat PDF Full paper]

**Citation: Aleisa, A.M., Helal, G., Alhaider, I.A., Alzoubi, K.H., Srivareerat, M., Tran, T.T., Al-Rejaie, S.S. and Alkadhi, K.A. (2011), Acute nicotine treatment prevents rem sleep deprivation-induced learning and memory impairment in rat. Hippocampus, 21: 899-909. https://doi.org/10.1002/hipo.20806

***Acknowledgement: None found

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@@ Line 1,507: / Line 1,507: @@
 ***Acknowledgement: Financial support: Academic Medical Center, Amsterdam, The Netherlands. Potential conflicts of interest: K.J.T. is cofounder of Critical Therapeutics Inc., a pharmaceutical company developing potential future treatment modalities based on the cholinergic anti-inflammatory pathway.
-='''Sleep Apnea'''=
+='''Sleep'''=
-===1991 [https://pubmed.ncbi.nlm.nih.gov/1859921/ Beneficial effects of nicotine]===
+==Apnea==
+===1991: [https://pubmed.ncbi.nlm.nih.gov/1859921/ Beneficial effects of nicotine]===
 *When chronically taken, nicotine may result in: protection against sleep apnea (other diseases / issues mentioned in study)
 *[https://sci-hub.st/10.1111/j.1360-0443.1991.tb01810.x PDF Version]
@@ Line 1,518: / Line 1,521: @@
 *[https://sci-hub.se/10.1378/chest.87.1.11 PDF Version]
 **Citation: Gothe B, Strohl KP, Levin S, Cherniack NS. Nicotine: a different approach to treatment of obstructive sleep apnea. Chest. 1985 Jan;87(1):11-7. doi: 10.1378/chest.87.1.11. PMID: 3965253.
+***Acknowledgement: None found
+==REM==
+===2017: [https://onlinelibrary.wiley.com/doi/10.1002/brb3.704 Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus]===
+*Animal study
+*MWM test found that REM sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM protein expression in CA1, CA2, CA3, and DG regions and the mean relative level of DREAM protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM protein.
+**Citation: Abd Rashid N, Hapidin H, Abdullah H, Ismail Z, Long I. Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus. Brain Behav. 2017; 7:e00704. https://doi.org/10.1002/brb3.704
+***Acknowledgement: This study was supported by the Universiti Sains Malaysia (USM) Short-Term Grant Scheme (304/PPSK/61312093), USM Research University grants (RUI) (1001/PPSK/812139) and Fundamental Research Grant Scheme (FRGS) (203/PPSK/6171153).
+===2011: [https://onlinelibrary.wiley.com/doi/10.1002/hipo.20806 Acute nicotine treatment prevents rem sleep deprivation-induced learning and memory impairment in rat]===
+*Animal Study
+*However, concurrent, acute treatment of rats with nicotine significantly attenuated SD-induced impairment of learning and STM and prevented SD-induced impairment of LTP in the CA1 and DG regions. These results show that acute nicotine treatment prevented the deleterious effect of sleep loss on cognitive abilities and synaptic plasticity.
+*[https://www.academia.edu/18461315/Acute_nicotine_treatment_prevents_REM_sleep_deprivation_induced_learning_and_memory_impairment_in_rat PDF Full paper]
+**Citation: Aleisa, A.M., Helal, G., Alhaider, I.A., Alzoubi, K.H., Srivareerat, M., Tran, T.T., Al-Rejaie, S.S. and Alkadhi, K.A. (2011), Acute nicotine treatment prevents rem sleep deprivation-induced learning and memory impairment in rat. Hippocampus, 21: 899-909. https://doi.org/10.1002/hipo.20806
+***Acknowledgement: None found
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