Nicotine - Retracted Studies, Papers, and Articles: Difference between revisions

==HPHC - Harmful and Potentially Harmful Constituents==

*The article has several serious shortcomings

**REPRODUCIBILITY AND LACK OF CRUCIAL INFORMATION.

*Referring to: Tehrani MW, Ahererra AD, Tanda S, Chen R, Borole A, Goessler W, Rule AM. Arsenic and arsenic species in MOD, POD, and disposable POD electronic cigarette aerosols: a pilot study. Journal of Environmental Exposure Assessment. 2023; 2(2): 9. http://dx.doi.org/10.20517/jeea.2023.03

*The reader may find the following commentary on Uguna & Snape by Chris Snowdon of interest. It includes a scientific review of the paper by Roberto Sussman that provides a convincing rebuttal of the author's assertions that heated tobacco products generate smoke. (Bates)

*Referring to: Uguna CN, Snape CE. Should IQOS Emissions Be Considered as Smoke and Harmful to Health? A Review of the Chemical Evidence. ACS Omega. 2022 Jun 22;7(26):22111-22124. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260752/ doi: 10.1021/acsomega.2c01527]. PMID: 35811880; PMCID: PMC9260752.

*"Conclusion. This study might be a correct and rigorous examination of various processes of the particulate phase of e-cigarette aerosol that are strictly valid under the abnormal overheating testing conditions. The study does not prove that such processes can occur in low powered devices, or even in high powered devices under the recommended power ranges and airflow rates normally used by consumers. The utility to assess the safety profile of e-cigarettes requires the devices to be tested under the best approximation possible to realistic usage. Unfortunately, this study failed to comply with this important consistency condition." (Sussman)

*Referring to: Dada O, Castillo K, Hogan M, Chalbot MG, Kavouras IG. Evidence for the coupling of refill liquids content and new particle formation in electronic cigarette vapors. Sci Rep. 2022 Nov 3;12(1):18571. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633786/ doi: 10.1038/s41598-022-21798-w]. PMID: 36329089; PMCID: PMC9633786.

*Multiple Comments

**"Users will operate the equipment in a way that does not lead to harsh dry puff conditions, with associated high VA formation. This is a key human control feedback that does not exist in laboratory equipment. So experiments that just standardise power settings or volume consumption must take care to validate these are realistic proxies for human use for a particular device. In this paper, many of the coil, power and volume settings combinations were not realistic. That could have been avoided through engaging with people with real practical expertise." (Bates)

*Referring to: Soha Talih, Rola Salman, Nareg Karaoghlanian, Ahmad El-Hellani, Najat Saliba, Thomas Eissenberg, and Alan Shihadeh Chemical Research in Toxicology 2017 30 (10), 1791-1793 [https://pubs.acs.org/doi/10.1021/acs.chemrestox.7b00212 DOI: 10.1021/acs.chemrestox.7b00212]

*"The problem for the authors is that cancer is a human condition and their calculation is based exposures measured by a lab machine in conditions that no humans would be able to tolerate." (Bates)

*See also: [https://pubpeer.com/publications/5D8FB0EB72850380D1A37DAA2097D6 PubPeer 2015-2017]