Nicotine therapeutic benefits: Difference between revisions

Line 1,055:

='''Pain / Analgesic'''=

===2023: [https://pubmed.ncbi.nlm.nih.gov/37132069/ Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study]===

*Perioperative high-dose nicotine replacement therapy may help to relieve postoperative pain among male smoking-abstinent patients undergoing abdominal surgery.

**Citation: Zhu C, Bi Y, Wei K, Tao K, Hu L, Lu Z. Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study. Addiction. 2023 Aug;118(8):1579-1585. doi: 10.1111/add.16224. Epub 2023 May 19. PMID: 37132069.

***Acknowledgement: Shanghai Municipal Science and Technology Commission. Grant Number: 17411960400

===2023: [https://www.mdpi.com/1424-8247/16/12/1665 The Anti-Nociceptive Effects of Nicotine in Humans: A Systematic Review and Meta-Analysis]===

*Conclusion: These results help to clarify the mixed outcomes of trials and may ultimately inform the treatment of pain. We observed that acute nicotine administration prolonged the laboratory-induced pain threshold and tolerance time and may mildly relieve postoperative pain. In addition, long-term tobacco smoking may have a nociceptive effect on different types of chronic pain. More research is needed to determine the anti-nociceptive effects of nicotine in humans, and to understand the optimal timing, dose, and method of delivery of nicotine.

@@ Line 1,055: / Line 1,055: @@
 ='''Pain / Analgesic'''=
+===2023: [https://pubmed.ncbi.nlm.nih.gov/37132069/ Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study]===
+*Perioperative high-dose nicotine replacement therapy may help to relieve postoperative pain among male smoking-abstinent patients undergoing abdominal surgery.
+**Citation: Zhu C, Bi Y, Wei K, Tao K, Hu L, Lu Z. Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing abdominal surgery: A randomized controlled pilot study. Addiction. 2023 Aug;118(8):1579-1585. doi: 10.1111/add.16224. Epub 2023 May 19. PMID: 37132069.
+***Acknowledgement: Shanghai Municipal Science and Technology Commission. Grant Number: 17411960400
 ===2023: [https://www.mdpi.com/1424-8247/16/12/1665 The Anti-Nociceptive Effects of Nicotine in Humans: A Systematic Review and Meta-Analysis]===
 *Conclusion: These results help to clarify the mixed outcomes of trials and may ultimately inform the treatment of pain. We observed that acute nicotine administration prolonged the laboratory-induced pain threshold and tolerance time and may mildly relieve postoperative pain. In addition, long-term tobacco smoking may have a nociceptive effect on different types of chronic pain. More research is needed to determine the anti-nociceptive effects of nicotine in humans, and to understand the optimal timing, dose, and method of delivery of nicotine.