Nicotine therapeutic benefits: Difference between revisions
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='''Allergies / Hayfever / Histamines'''= | ='''Allergies / Hayfever / Histamines'''= | ||
*See also: Hypersensitivity Pneumonitis / Extrinsic Allergic Alveolitis | *'''See also: Hypersensitivity Pneumonitis / Extrinsic Allergic Alveolitis''' | ||
===2020 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203434/ Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation]=== | ===2020 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203434/ Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation]=== | ||
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**Citation: Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M. Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888. PMID: 24454942; PMCID: PMC3894205. | **Citation: Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M. Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888. PMID: 24454942; PMCID: PMC3894205. | ||
=== | ===2008: [https://journals.aai.org/jimmunol/article/180/11/7655/84640/Nicotine-Primarily-Suppresses-Lung-Th2-but-Not Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens]=== | ||
*Animal Study | *Animal Study | ||
* | *hese results suggest that nicotine modulates allergy/asthma primarily by suppressing eosinophil trafficking and suppressing Th2 cytokine/chemokine responses without reducing goblet cell metaplasia, mucous production, and may explain the lower risk of allergic diseases in smokers. To our knowledge this is the first direct evidence that nicotine modulates allergic responses. | ||
**Citation: Mishra | **Citation: Neerad C. Mishra, Jules Rir-sima-ah, Raymond J. Langley, Shashi P. Singh, Juan C. Peña-Philippides, Takeshi Koga, Seddigheh Razani-Boroujerdi, Julie Hutt, Matthew Campen, K. Chul Kim, Yohannes Tesfaigzi, Mohan L. Sopori; Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens1. J Immunol 1 June 2008; 180 (11): 7655–7663. https://doi.org/10.4049/jimmunol.180.11.7655 | ||
*** | ***Acknowledgement: This work was supported in part by grants from the National Institutes of Health (R01-DA017003, R01-DA04208-15, and R01-DA042087S). | ||
===2004: [https://link.springer.com/article/10.1007/s00011-004-1249-1 The effect of nicotine on basophil histamine release]=== | ===2004: [https://link.springer.com/article/10.1007/s00011-004-1249-1 The effect of nicotine on basophil histamine release]=== | ||