Nicotine therapeutic benefits: Difference between revisions

Line 1,574:

*[https://sci-hub.st/10.1111/j.1346-8138.1995.tb03904.x PDF Version]

**Citation: Kanekura T, Kanzaki T. Successful treatment of pyoderma gangrenosum with nicotine chewing gum. J Dermatol. 1995 Sep;22(9):704-5. doi: 10.1111/j.1346-8138.1995.tb03904.x. PMID: 8537562.

<br>

='''Rett syndrome'''=

===2016: [https://www.nature.com/articles/cr201648 Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus]===

*Animal Study

*In addition, application of PNU282987 or nicotine rescued impaired social interaction and anxiolytic behaviors in Chat-Mecp2−/y mice.

*Nicotine appears to be the primary agent in cigarettes that can target all nAChRs, including α7 nAChRs. Application of nicotine also rescued the behavioral phenotypes of Chat-Mecp2−/y mice. Long-term delivery of nicotine in the hippocampus also improved social memory in WT mice...Of particular importance, intracerebral infusion of PNU282987 or nicotine rescued the behavioral defects in Chat-Mecp2−/y mice. These findings suggest that MeCP2 is critical for normal function of cholinergic neurons and dysfunction of cholinergic neurons can contribute to numerous neuropsychiatric phenotypes.

**Citation: Zhang Y, Cao SX, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg DK, Duan S, Li XM. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus. Cell Res. 2016 Jun;26(6):728-42. doi: 10.1038/cr.2016.48. Epub 2016 Apr 22. PMID: 27103432; PMCID: PMC4897179.

***Acknowledgement: This work was supported by the National Natural Science Foundation of China for Distinguished Young Scientists (81225007), Key Project of the National Natural Science Foundation of China (31430034), Major Research Plan of the National Natural Science Foundation of China (91432306), Funds for Creative Research Groups of China (81221003), Program for Changjiang Scholars and Innovative Research Team in University, and Fundamental Research Funds for the Central Universities. This work was also sponsored by the Zhejiang Province Program for Cultivation of High-level Health Talents.

<br>

='''Sarcoidosis'''=

===2021 [https://journal.chestnet.org/article/S0012-3692(21)01282-4/fulltext Promise of Nicotine as a Treatment for Pulmonary Sarcoidosis]===

===2021 [https://journal.chestnet.org/article/S0012-3692(21)00962-4/fulltext A Pilot Randomized Trial of Transdermal Nicotine for Pulmonary Sarcoidosis]===

@@ Line 1,574: / Line 1,574: @@
 *[https://sci-hub.st/10.1111/j.1346-8138.1995.tb03904.x PDF Version]
 **Citation: Kanekura T, Kanzaki T. Successful treatment of pyoderma gangrenosum with nicotine chewing gum. J Dermatol. 1995 Sep;22(9):704-5. doi: 10.1111/j.1346-8138.1995.tb03904.x. PMID: 8537562.
+<br>
+='''Rett syndrome'''=
+===2016: [https://www.nature.com/articles/cr201648 Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus]===
+*Animal Study
+*In addition, application of PNU282987 or nicotine rescued impaired social interaction and anxiolytic behaviors in Chat-Mecp2−/y mice.
+*Nicotine appears to be the primary agent in cigarettes that can target all nAChRs, including α7 nAChRs. Application of nicotine also rescued the behavioral phenotypes of Chat-Mecp2−/y mice. Long-term delivery of nicotine in the hippocampus also improved social memory in WT mice...Of particular importance, intracerebral infusion of PNU282987 or nicotine rescued the behavioral defects in Chat-Mecp2−/y mice. These findings suggest that MeCP2 is critical for normal function of cholinergic neurons and dysfunction of cholinergic neurons can contribute to numerous neuropsychiatric phenotypes.
+**Citation: Zhang Y, Cao SX, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg DK, Duan S, Li XM. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus. Cell Res. 2016 Jun;26(6):728-42. doi: 10.1038/cr.2016.48. Epub 2016 Apr 22. PMID: 27103432; PMCID: PMC4897179.
+***Acknowledgement: This work was supported by the National Natural Science Foundation of China for Distinguished Young Scientists (81225007), Key Project of the National Natural Science Foundation of China (31430034), Major Research Plan of the National Natural Science Foundation of China (91432306), Funds for Creative Research Groups of China (81221003), Program for Changjiang Scholars and Innovative Research Team in University, and Fundamental Research Funds for the Central Universities. This work was also sponsored by the Zhejiang Province Program for Cultivation of High-level Health Talents.
 <br>
 ='''Sarcoidosis'''=
 ===2021 [https://journal.chestnet.org/article/S0012-3692(21)01282-4/fulltext Promise of Nicotine as a Treatment for Pulmonary Sarcoidosis]===
 ===2021 [https://journal.chestnet.org/article/S0012-3692(21)00962-4/fulltext A Pilot Randomized Trial of Transdermal Nicotine for Pulmonary Sarcoidosis]===