ENDS Toxicity / Carcinogenic: Difference between revisions

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*Article in Lung Disease News: [https://lungdiseasenews.com/2017/08/25/study-finds-that-cancer-risk-of-e-cigarettes-is-much-lower-than-that-of-cigarette-smoke/?fbclid=IwAR1qEBP2dW4ccXc0fUEWpZIR6ZpsBJwMw-tDsB_PFiiHgR4XaJRaIAbutl4 E-Cigarettes Carry Much Less Risk of Lung Cancer Than Cigarette Smoke, Study Finds]  
*Article in Lung Disease News: [https://lungdiseasenews.com/2017/08/25/study-finds-that-cancer-risk-of-e-cigarettes-is-much-lower-than-that-of-cigarette-smoke/?fbclid=IwAR1qEBP2dW4ccXc0fUEWpZIR6ZpsBJwMw-tDsB_PFiiHgR4XaJRaIAbutl4 E-Cigarettes Carry Much Less Risk of Lung Cancer Than Cigarette Smoke, Study Finds]  
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/27/1/10.full.pdf PDF Version]
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/27/1/10.full.pdf PDF Version]
*Citation: Stephens WEComparing the cancer potencies of emissions from vapourised nicotine products including e-cigarettes with those of tobacco smokeTobacco Control 2018;27:10-17.
*Citation: Stephens WE Comparing the cancer potencies of emissions from vapourised (vaporised) nicotine products including e-cigarettes with those of tobacco smoke Tobacco Control 2018;27:10-17.


===2016: [https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke-tobacco-harm-reduction Royal College of Physicians - Nicotine without Smoke]===  
===2016: [https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke-tobacco-harm-reduction Royal College of Physicians - Nicotine without Smoke]===  
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*E-cigarettes are marketed as consumer products and are proving much more popular than NRT as a substitute and competitor for tobacco cigarettes.
*E-cigarettes are marketed as consumer products and are proving much more popular than NRT as a substitute and competitor for tobacco cigarettes.
*E-cigarettes appear to be effective when used by smokers as an aid to quitting smoking.
*E-cigarettes appear to be effective when used by smokers as an aid to quitting smoking.
*The hazard to health arising from long-term vapour inhalation from the e-cigarettes available today is unlikely to exceed 5% of the harm from smoking tobacco.
*The hazard to health arising from long-term vapour (vapor) inhalation from the e-cigarettes available today is unlikely to exceed 5% of the harm from smoking tobacco.
*In the interests of public health it is important to promote the use of e-cigarettes, NRT and other non-tobacco nicotine products as widely as possible as a substitute for smoking…
*In the interests of public health it is important to promote the use of e-cigarettes, NRT and other non-tobacco nicotine products as widely as possible as a substitute for smoking…
*[https://www.rcplondon.ac.uk/file/3563/download PDF Version]
*[https://www.rcplondon.ac.uk/file/3563/download PDF Version]
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*[https://sci-hub.se/10.1016/j.mrgentox.2016.10.005 PDF Version]
*[https://sci-hub.se/10.1016/j.mrgentox.2016.10.005 PDF Version]
*Citation: Thorne, D., Crooks, I., Hollings, M., Seymour, A., Meredith, C., & Gaca, M. (2016). The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 812, 29–38. doi:10.1016/j.mrgentox.2016.10.005  
*Citation: Thorne, D., Crooks, I., Hollings, M., Seymour, A., Meredith, C., & Gaca, M. (2016). The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 812, 29–38. doi:10.1016/j.mrgentox.2016.10.005  
*Acknowledgement: The authors are employees of British American Tobacco or Covance Laboratories Ltd. Covance Laboratories Ltd., Harrogate, UK,
*Acknowledgement: The authors are employees of British American Tobacco or Covance Laboratories Ltd. Covance Laboratories Ltd., Harrogate, UK, conducted all experimental work and were funded by BritishAmerican Tobacco. Nicoventures Ltd., UK, is a wholly-owned subsidiary of British American Tobacco.
conducted all experimental work and were funded by BritishAmerican Tobacco. Nicoventures Ltd., UK, is a wholly-owned subsidiary
of British American Tobacco.




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*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154473/pdf/nihms-624084.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154473/pdf/nihms-624084.pdf PDF Version]
*Citation: Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, Jacob P 3rd, Benowitz N. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014 Mar;23(2):133-9. doi: 10.1136/tobaccocontrol-2012-050859. Epub 2013 Mar 6. PMID: 23467656; PMCID: PMC4154473.
*Citation: Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, Jacob P 3rd, Benowitz N. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014 Mar;23(2):133-9. doi: 10.1136/tobaccocontrol-2012-050859. Epub 2013 Mar 6. PMID: 23467656; PMCID: PMC4154473.
*Acknowledgement: This study was conducted while the first author was at Medical University of Silesia, Poland and was supported by
*Acknowledgement: This study was conducted while the first author was at Medical University of Silesia, Poland and was supported by the Ministry of Science and Higher Education of Poland under grant number N N404 025638. Analysis of nitrosamines at the University of California, San Francisco was supported by grants P30 DA012393 and S10 RR026437 from the National Institutes of Health.
the Ministry of Science and Higher Education of Poland under grant number N N404 025638. Analysis of nitrosamines at the University of California,
San Francisco was supported by grants P30 DA012393 and S10 RR026437 from the National Institutes of Health.


===2014 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481723/ Evaluation of Toxicant and Carcinogen Metabolites in the Urine of E-Cigarette Users  Versus Cigarette Smokers]===   
===2014 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481723/ Evaluation of Toxicant and Carcinogen Metabolites in the Urine of E-Cigarette Users  Versus Cigarette Smokers]===   
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*Acknowledgement: This work was supported by the National Cancer Institute at the National Institutes of Health (R01 CA081301, U19 CA157345, and CA77598).
*Acknowledgement: This work was supported by the National Cancer Institute at the National Institutes of Health (R01 CA081301, U19 CA157345, and CA77598).


===2013 Cytotoxicity evaluation of electronic cigarette (EC) vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke (CS) extract  
===2013 [https://www.tandfonline.com/doi/full/10.3109/08958378.2013.793439 Cytotoxicity evaluation of electronic cigarette (EC) vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke (CS) extract]===
*This study indicates that EC vapor is significantly less cytotoxic compared to tobacco CS.
*This study indicates that EC vapor is significantly less cytotoxic compared to tobacco CS.
*[https://sci-hub.se/10.3109/08958378.2013.793439 PDF Version]
*Citation: Romagna, G., Allifranchini, E., Bocchietto, E., Todeschi, S., Esposito, M., & Farsalinos, K. E. (2013). Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract. Inhalation Toxicology, 25(6), 354–361. doi:10.3109/08958378.2013.793439
*Acknowledgement: The study was funded by FlavourArt s.r.l. No author has received any financial compensation for this study. The study was investigator-initiated and investigator-driven. The sponsor had no involvement in the study design, data collection, analysis and interpretation, writing or approving the manuscript and decision to submit the manuscript for publication.
*Keywords: Cytotoxicity, electronic cigarette, fibroblasts, in vitro, nicotine, smoking, tobacco harm reduction


==ENDS (without comparison to other products)==
==ENDS (without comparison to other products)==