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* The biomarker levels of many tobacco-related toxicants measured in biological samples collected from ENDS users did not differ significantly from non-users, except for nicotine metabolites and a small number of biomarkers of exposure to volatile organic compounds and tobacco-specific tobacco nitrosamines. Several studies have shown that while exposed to nicotine, long-term exclusive ENDS users showed significantly lower levels of toxicant biomarkers than cigarette smokers. | * The biomarker levels of many tobacco-related toxicants measured in biological samples collected from ENDS users did not differ significantly from non-users, except for nicotine metabolites and a small number of biomarkers of exposure to volatile organic compounds and tobacco-specific tobacco nitrosamines. Several studies have shown that while exposed to nicotine, long-term exclusive ENDS users showed significantly lower levels of toxicant biomarkers than cigarette smokers. | ||
* Goniewicz ML. Addict Neurosci. 2023 Jun;6:100077. doi: 10.1016/j.addicn.2023.100077. Epub 2023 Feb 26. PMID: 3708924 | * Goniewicz ML. Addict Neurosci. 2023 Jun;6:100077. doi: 10.1016/j.addicn.2023.100077. Epub 2023 Feb 26. PMID: 3708924 | ||
===2023: [https://www.nature.com/articles/s41598-023-44626-1 Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: the REPLICA project]=== | |||
*The results showed high cytotoxicity, mutagenicity and genotoxicity induced by cigarette smoke, but slight or no cytotoxic, mutagenic and genotoxic effects induced by the e-cigarette aerosol. Although the two studies presented some methodological differences, the findings supported those previously presented by Rudd and colleagues. | |||
*Emma, R., Fuochi, V., Distefano, A., Partsinevelos, K., Rust, S., Zadjali, F., Al Tobi, M., Zadjali, R., Alharthi, Z., Pulvirenti, R., Furneri, P. M., Polosa, R., Sun, A., Caruso, M., & Li Volti, G. (2023). Cytotoxicity, mutagenicity and genotoxicity of electronic cigarettes emission aerosols compared to cigarette smoke: The REPLICA project. Scientific Reports, 13(1), 1-12. https://doi.org/10.1038/s41598-023-44626-1 | |||
===2021: [https://www.sciencedirect.com/science/article/abs/pii/S0273230021001598 Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes]=== | ===2021: [https://www.sciencedirect.com/science/article/abs/pii/S0273230021001598 Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes]=== | ||
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