Myth: Alternative nicotine products don't help people stop smoking: Difference between revisions

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='''No Intention of Quitting Smoking (Accidental Quitters)'''=
='''No Intention of Quitting Smoking (Accidental Quitters)'''=
===2024: [https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntae047/7623369 Using pod based e-cigarettes and nicotine pouches to reduce harm for adults with low socioeconomic status who smoke: A pilot randomized controlled trial]===
*This study provides novel evidence that e-cigarettes and nicotine pouches can be a harm reduction tool for individuals with lower SES who smoke and are not willing to quit smoking, contributing to reducing tobacco-related disparities in this population.


===2023: [https://link.springer.com/article/10.1007/s00213-023-06401-y Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches]===
===2023: [https://link.springer.com/article/10.1007/s00213-023-06401-y Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches]===
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* In smokers not intending to quit, the use of e-cigarettes<kbd>,</kbd> with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.
* In smokers not intending to quit, the use of e-cigarettes<kbd>,</kbd> with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.
* Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M, Russo C, Polosa R. PLoS One. 2013 Jun 24;8(6):e66317. doi: 10.1371/journal.pone.0066317
* Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M, Russo C, Polosa R. PLoS One. 2013 Jun 24;8(6):e66317. doi: 10.1371/journal.pone.0066317
===2011: [https://pubmed.ncbi.nlm.nih.gov/21989407/ Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study]===
*Sustained 50% reduction in the number of cig/day at week-24 was shown in 13/40(32.5%) participants; their median of 25 cigs/day decreasing to 6 cigs/day (p < 0.001). Sustained 80% reduction was shown in 5/40(12.5%) participants; their median of 30 cigs/day decreasing to 3 cigs/day (p = 0.043). Sustained smoking abstinence at week-24 was observed in 9/40(22.5%) participants, with 6/9 still using the e-Cigarette by the end of the study. Combined sustained 50% reduction and smoking abstinence was shown in 22/40 (55%) participants, with an overall 88% fall in cigs/day.
*The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203079/pdf/1471-2458-11-786.pdf PDF Version]
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='''Combined Intending and Not Intending to Quit Smoking'''=
='''Combined Intending and Not Intending to Quit Smoking'''=
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*Nicotine’s beneficial effects can be controlled, and the detrimental effects of the smoky delivery system can be attenuated, by providing the drug via less hazardous delivery systems. Although more research is needed, e-cigs appear to be effective cigarette substitutes for inveterate smokers, and the health improvements enjoyed by switchers do not differ from those enjoyed by tobacco/nicotine abstainers.
*Nicotine’s beneficial effects can be controlled, and the detrimental effects of the smoky delivery system can be attenuated, by providing the drug via less hazardous delivery systems. Although more research is needed, e-cigs appear to be effective cigarette substitutes for inveterate smokers, and the health improvements enjoyed by switchers do not differ from those enjoyed by tobacco/nicotine abstainers.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850892/pdf/1477-7517-10-19.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850892/pdf/1477-7517-10-19.pdf PDF Version]
===2013: [https://academic.oup.com/ntr/article/15/10/1737/1183788 E-Cigarettes: Prevalence and Attitudes in Great Britain]===
*While we found evidence supporting the view that e-cigarette use may be a bridge to quitting, we found very little evidence of e-cigarette use among adults who had never smoked. British smokers would benefit from information about the effective use, risks, and benefits of e-cigarettes, as this might enable the use of e-cigarettes to improve public health.
*[https://scholar.google.com/scholar_url?url=https://academic.oup.com/ntr/article-pdf/15/10/1737/4005852/ntt057.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=5-niYKGiHo6RywT0wZbgCg&scisig=AAGBfm1x30ekBGwfhPgkxdJKFW0eOfPFPw PDF Version]
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*This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical.
*This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical.
*[https://sci-hub.st/10.1093/ntr/ntu103 PDF Version]
*[https://sci-hub.st/10.1093/ntr/ntu103 PDF Version]
===2013: [https://pubmed.ncbi.nlm.nih.gov/23551515/ 'Vaping' profiles and preferences: an online survey of electronic cigarette users]===
*Seventy-four percent of participants reported not smoking for at least a few weeks since using the e-cigarette and 70% reported reduced urge to smoke. *Seventy-two percent of participants used a 'tank' system, most commonly. Mean duration of use was 10 months. Only 1% reported exclusive use of non-nicotine containing liquid. E-cigarettes were generally considered to be satisfying to use; elicit few side effects; be healthier than smoking; improve cough/breathing; and be associated with low levels of craving. Among ex-smokers, 'time to first vape' was significantly longer than 'time to first cigarette' suggesting a lower level of dependence to e-cigarettes. Ex-smokers reported significantly greater reduction in craving than current smokers.
*E-cigarettes are used primarily for smoking cessation, but for a longer duration than nicotine replacement therapy, and users believe them to be safer than smoking
*[https://sci-hub.st/10.1111/add.12150 PDF Version]
===2012: [https://www.sciencedirect.com/science/article/abs/pii/S0306460312000913 The electronic-cigarette: Effects on desire to smoke, withdrawal symptoms and cognition]===
*The e-cigarette can reduce desire to smoke and nicotine withdrawal symptoms 20 minutes after use.
*The nicotine content in this respect may be more important for males.
*The first study to demonstrate that the nicotine e-cigarette can improve working memory.
*[https://sci-hub.se/10.1016/j.addbeh.2012.03.004 PDF Version]
===2011: [https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-5-585 Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case series]===
*The most important message from this case series is that these smokers, with a documented history of recurring relapses, were able to quit smoking and to remain abstinent for at least six months after taking up an electronic cigarette.
*[https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/1752-1947-5-585.pdf PDF Version]
===2011: [https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1360-0443.2011.03505.x Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy]===
*Almost all (97%) used e‐cigarettes containing nicotine.
*Most (96%) said the e‐cigarette helped them to quit smoking or reduce their smoking (92%).
*Reasons for using the e‐cigarette included the perception that it was less toxic than tobacco (84%), to deal with craving for tobacco (79%) and withdrawal symptoms (67%), to quit smoking or avoid relapsing (77%), because it was cheaper than smoking (57%) and to deal with situations where smoking was prohibited (39%).
*Most ex‐smokers (79%) feared they might relapse to smoking if they stopped using the e‐cigarette.
*Users of nicotine‐containing e‐cigarettes reported better relief of withdrawal and a greater effect on smoking cessation than those using non‐nicotine e‐cigarettes.
*[https://sci-hub.se/10.1111/j.1360-0443.2011.03505.x PDF Version]
===2011: [https://www.sciencedirect.com/science/article/abs/pii/S0749379710007920 Electronic Cigarettes As a Smoking-Cessation Tool: Results from an Online Survey]===
*A large percentage of respondents reported a reduction in the number of cigarettes they smoked (66.8%) and almost half reported abstinence from smoking for a period of time (48.8%). Those respondents using e-cigarettes more than 20 times per day had a quit rate of 70.0%. Of respondents who were not smoking at 6 months, 34.3% were not using e-cigarettes or any nicotine-containing products at the time.
*The distinct and unique advantage of e-cigarettes is that they allow individuals to utilize one device that can simultaneously address nicotine withdrawal, psychological factors, and behavioral cues that serve as barriers to smoking abstinence.
*[https://sci-hub.se/10.1016/j.amepre.2010.12.006 PDF Version]
===2011: [https://academic.oup.com/ntr/article/13/9/860/1134354 Interviews With “Vapers”: Implications for Future Research With Electronic Cigarettes]===
*Experienced users report health gains typical for smoking cessation despite continued vaping.
*There were pervasive themes including the language and culture of vaping; social and informational support among vapers, motives and perceived benefits of using e-cigs versus cigarettes including cigarette-like enjoyment, cost, restored sense of taste and smell, and improved breathing and exercise tolerance; rapidly reduced nicotine tolerance and dependence; and a strong interest in e-cig–related research and policy.
*[https://sci-hub.se/10.1093/ntr/ntr088 PDF Version]
===2010: [https://tobaccocontrol.bmj.com/content/19/2/98 Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial]===
*Conclusions “The 16 mg Ruyan V8 ENDD alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette. Evaluation of the ENDD for longer-term safety, potential for long-term use and efficacy as a cessation aid is needed.”
*[https://sci-hub.se/10.1136/tc.2009.031567 PDF Version]
===2010: [https://link.springer.com/article/10.1186/1471-2458-10-231 Electronic cigarettes: a survey of users]===
*Our results suggest that ecigarettes are used mainly to quit smoking, and may be useful for this purpose.
*[https://link.springer.com/content/pdf/10.1186%2F1471-2458-10-231.pdf PDF Version]
===2006: [https://tobaccocontrol.bmj.com/content/15/3/210 Role of snus in initiation and cessation of tobacco smoking in Sweden]===
*Use of snus in Sweden is associated with a reduced risk of becoming a daily smoker, and increased likelihood of stopping smoking
===2005: [https://tobaccocontrol.bmj.com/content/14/6/422 Is Swedish snus associated with smoking initiation or smoking cessation?]===
*“Among males participating in a large population based twin study in Sweden, snus use was associated with smoking cessation but not initiation.”
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/14/6/422.full.pdf PDF Version]
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===See Also: [https://safernicotine.wiki/mediawiki/index.php/ENDS_Flavors ENDS - Flavors] and [https://safernicotine.wiki/mediawiki/index.php/Nicotine_-_Banning_Flavors_-_Opposition Nicotine - Banning Flavors - Opposition]===
===See Also: [https://safernicotine.wiki/mediawiki/index.php/ENDS_Flavors ENDS - Flavors] and [https://safernicotine.wiki/mediawiki/index.php/Nicotine_-_Banning_Flavors_-_Opposition Nicotine - Banning Flavors - Opposition]===
===2023: [https://pubmed.ncbi.nlm.nih.gov/38127516/ Randomized trial assessing the effect of the JUUL system on switching away from cigarettes and smoking reduction among U.S. adults who smoke cigarettes]===
*Use of JUUL products may support complete switching away from cigarettes, including among those not ready to quit smoking. Results suggest a preference for nontobacco-flavored ENDS among adults who smoke, although smoking outcomes did not differ by flavor.


===2022: [https://pubmed.ncbi.nlm.nih.gov/36250607/ Associations between e-cigarette use and e-cigarette flavors with cigarette smoking quit attempts and quit success: Evidence from a US large, nationally representative 2018-2019 survey]===
===2022: [https://pubmed.ncbi.nlm.nih.gov/36250607/ Associations between e-cigarette use and e-cigarette flavors with cigarette smoking quit attempts and quit success: Evidence from a US large, nationally representative 2018-2019 survey]===
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*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751515/pdf/nty141.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751515/pdf/nty141.pdf PDF Version]


= Long Term usage =
= '''Long Term usage''' =


=== 2023: [https://pubmed.ncbi.nlm.nih.gov/37866230/ An 8-year longitudinal study of long-term, continuous users of electronic cigarettes.] (2012-2016 to 2021 8 years is the average) ===
=== 2023: [https://pubmed.ncbi.nlm.nih.gov/37866230/ An 8-year longitudinal study of long-term, continuous users of electronic cigarettes.] (2012-2016 to 2021 8 years is the average) ===
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=Drug or Alcohol Treatment Facilities=
=Drug or Alcohol Treatment Facilities=
=Studies - Not Catagorized=
===2013: [https://www.frontiersin.org/articles/10.3389/fpubh.2013.00056/full Electronic cigarettes and vaping: a new challenge in clinical medicine and public health. A literature review]===
*When compared to the harmful effects of smoking, these studies suggest that vaping could be used as a possible “harm reduction” tool. There is evidence supporting e-cigarettes as an aide for smoking cessation, at least as successful as currently available FDA-approved NRTs.
===2013: [https://academic.oup.com/ntr/article/15/10/1737/1183788 E-Cigarettes: Prevalence and Attitudes in Great Britain]===
*While we found evidence supporting the view that e-cigarette use may be a bridge to quitting, we found very little evidence of e-cigarette use among adults who had never smoked. British smokers would benefit from information about the effective use, risks, and benefits of e-cigarettes, as this might enable the use of e-cigarettes to improve public health.
*[https://scholar.google.com/scholar_url?url=https://academic.oup.com/ntr/article-pdf/15/10/1737/4005852/ntt057.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=5-niYKGiHo6RywT0wZbgCg&scisig=AAGBfm1x30ekBGwfhPgkxdJKFW0eOfPFPw PDF Version]
===2013: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691171/ EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study]===
*In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects. In view of the fact that subjects in this study had no immediate intention of quitting, the reported overall abstinence rate of 8.7% at 52-week was remarkable.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691171/pdf/pone.0066317.pdf PDF Version]
===2013: [https://pubmed.ncbi.nlm.nih.gov/23551515/ 'Vaping' profiles and preferences: an online survey of electronic cigarette users]===
*Seventy-four percent of participants reported not smoking for at least a few weeks since using the e-cigarette and 70% reported reduced urge to smoke. *Seventy-two percent of participants used a 'tank' system, most commonly. Mean duration of use was 10 months. Only 1% reported exclusive use of non-nicotine containing liquid. E-cigarettes were generally considered to be satisfying to use; elicit few side effects; be healthier than smoking; improve cough/breathing; and be associated with low levels of craving. Among ex-smokers, 'time to first vape' was significantly longer than 'time to first cigarette' suggesting a lower level of dependence to e-cigarettes. Ex-smokers reported significantly greater reduction in craving than current smokers.
*E-cigarettes are used primarily for smoking cessation, but for a longer duration than nicotine replacement therapy, and users believe them to be safer than smoking
*[https://sci-hub.st/10.1111/add.12150 PDF Version]
===2012: [https://www.sciencedirect.com/science/article/abs/pii/S0306460312000913 The electronic-cigarette: Effects on desire to smoke, withdrawal symptoms and cognition]===
*The e-cigarette can reduce desire to smoke and nicotine withdrawal symptoms 20 minutes after use.
*The nicotine content in this respect may be more important for males.
*The first study to demonstrate that the nicotine e-cigarette can improve working memory.
*[https://sci-hub.se/10.1016/j.addbeh.2012.03.004 PDF Version]
===2011: [https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-5-585 Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case series]===
*The most important message from this case series is that these smokers, with a documented history of recurring relapses, were able to quit smoking and to remain abstinent for at least six months after taking up an electronic cigarette.
*[https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/1752-1947-5-585.pdf PDF Version]
===2011: [https://pubmed.ncbi.nlm.nih.gov/21989407/ Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study]===
*Sustained 50% reduction in the number of cig/day at week-24 was shown in 13/40(32.5%) participants; their median of 25 cigs/day decreasing to 6 cigs/day (p < 0.001). Sustained 80% reduction was shown in 5/40(12.5%) participants; their median of 30 cigs/day decreasing to 3 cigs/day (p = 0.043). Sustained smoking abstinence at week-24 was observed in 9/40(22.5%) participants, with 6/9 still using the e-Cigarette by the end of the study. Combined sustained 50% reduction and smoking abstinence was shown in 22/40 (55%) participants, with an overall 88% fall in cigs/day.
*The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203079/pdf/1471-2458-11-786.pdf PDF Version]
===2011: [https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1360-0443.2011.03505.x Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy]===
*Almost all (97%) used e‐cigarettes containing nicotine.
*Most (96%) said the e‐cigarette helped them to quit smoking or reduce their smoking (92%).
*Reasons for using the e‐cigarette included the perception that it was less toxic than tobacco (84%), to deal with craving for tobacco (79%) and withdrawal symptoms (67%), to quit smoking or avoid relapsing (77%), because it was cheaper than smoking (57%) and to deal with situations where smoking was prohibited (39%).
*Most ex‐smokers (79%) feared they might relapse to smoking if they stopped using the e‐cigarette.
*Users of nicotine‐containing e‐cigarettes reported better relief of withdrawal and a greater effect on smoking cessation than those using non‐nicotine e‐cigarettes.
*[https://sci-hub.se/10.1111/j.1360-0443.2011.03505.x PDF Version]
===2011: [https://www.sciencedirect.com/science/article/abs/pii/S0749379710007920 Electronic Cigarettes As a Smoking-Cessation Tool: Results from an Online Survey]===
*A large percentage of respondents reported a reduction in the number of cigarettes they smoked (66.8%) and almost half reported abstinence from smoking for a period of time (48.8%). Those respondents using e-cigarettes more than 20 times per day had a quit rate of 70.0%. Of respondents who were not smoking at 6 months, 34.3% were not using e-cigarettes or any nicotine-containing products at the time.
*The distinct and unique advantage of e-cigarettes is that they allow individuals to utilize one device that can simultaneously address nicotine withdrawal, psychological factors, and behavioral cues that serve as barriers to smoking abstinence.
*[https://sci-hub.se/10.1016/j.amepre.2010.12.006 PDF Version]
===2011: [https://academic.oup.com/ntr/article/13/9/860/1134354 Interviews With “Vapers”: Implications for Future Research With Electronic Cigarettes]===
*Experienced users report health gains typical for smoking cessation despite continued vaping.
*There were pervasive themes including the language and culture of vaping; social and informational support among vapers, motives and perceived benefits of using e-cigs versus cigarettes including cigarette-like enjoyment, cost, restored sense of taste and smell, and improved breathing and exercise tolerance; rapidly reduced nicotine tolerance and dependence; and a strong interest in e-cig–related research and policy.
*[https://sci-hub.se/10.1093/ntr/ntr088 PDF Version]
===2010: [https://tobaccocontrol.bmj.com/content/19/2/98 Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial]===
*Conclusions “The 16 mg Ruyan V8 ENDD alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette. Evaluation of the ENDD for longer-term safety, potential for long-term use and efficacy as a cessation aid is needed.”
*[https://sci-hub.se/10.1136/tc.2009.031567 PDF Version]
===2010: [https://link.springer.com/article/10.1186/1471-2458-10-231 Electronic cigarettes: a survey of users]===
*Our results suggest that ecigarettes are used mainly to quit smoking, and may be useful for this purpose.
*[https://link.springer.com/content/pdf/10.1186%2F1471-2458-10-231.pdf PDF Version]
===2006: [https://tobaccocontrol.bmj.com/content/15/3/210 Role of snus in initiation and cessation of tobacco smoking in Sweden]===
*Use of snus in Sweden is associated with a reduced risk of becoming a daily smoker, and increased likelihood of stopping smoking
===2005: [https://tobaccocontrol.bmj.com/content/14/6/422 Is Swedish snus associated with smoking initiation or smoking cessation?]===
*“Among males participating in a large population based twin study in Sweden, snus use was associated with smoking cessation but not initiation.”
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/14/6/422.full.pdf PDF Version]


='''Shareables'''=
='''Shareables'''=
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='''Suggestions to Add to This Page'''=
='''Suggestions to Add to This Page'''=


===2023: [https://pubmed.ncbi.nlm.nih.gov/38127516/ Randomized trial assessing the effect of the JUUL system on switching away from cigarettes and smoking reduction among U.S. adults who smoke cigarettes]===
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