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== | ==2021: Balancing Consideration of the Risks and Benefits of E-Cigarettes== | ||
*[https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2021.306416 Balancing Consideration of the Risks and Benefits of E-Cigarettes] | |||
*"Animal model studies have found that nicotine can affect maturation of brain parts associated with executive function and decision-making, potentially leading to more impulsive behavior, cognitive deficits, and greater likelihood to self-administer other drugs. In addition, there is evidence in humans of neurological changes attributed to nicotine in the brains of adolescent smokers, interpreted by some as reflecting similar harmful effects to those in the animal models." | |||
*"These studies lead some researchers to suspect that adolescent nicotine use in any form may lead to long-term structural and functional brain changes with associated negative implications for cognition or impulse control. However, given species differences and questions about the relevance of experimental animal nicotine dosing paradigms to human use patterns, the validity of extrapolation to humans is speculative. Whether impaired brain development with behavioral consequences occurs in young nicotine consumers is difficult to determine because of potential confounding of genetic and socioeconomic factors, the influence of other substance abuse, and the role of preexisting neuropsychiatric problems associated with youth smoking. Research has yet to isolate nicotine use in the adolescent years and then examine later sequelae. Still, concerns about brain function effects of nicotine exposure through vaping deserve serious examination." | |||
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==2020: Clive Bates== | |||
*[https://www.clivebates.com/vaping-tobacco-harm-reduction-nicotine-science-and-policy-q-a/ Nicotine science and policy Q & A] | |||
*No, this is a scare story and the claims do not bear scrutiny. Some public figures, including the US Surgeon General, have suggested that nicotine damages the adolescent brain. The evidence for this hypothesis comes only from a few rodent studies. These are an unreliable guide to human risk because the rodent brain does not offer a reliable proxy for the human brain and it is difficult to design experiments that are controlled to give a mouse equivalent exposure to a human. | *No, this is a scare story and the claims do not bear scrutiny. Some public figures, including the US Surgeon General, have suggested that nicotine damages the adolescent brain. The evidence for this hypothesis comes only from a few rodent studies. These are an unreliable guide to human risk because the rodent brain does not offer a reliable proxy for the human brain and it is difficult to design experiments that are controlled to give a mouse equivalent exposure to a human. | ||
*But this is not the main reason for doubt. Over the last 60 years, millions of adolescent nicotine users have grown up as smokers and either continue to use nicotine or have quit. The problem for the Surgeon General and others is that there is no sign of any cognitive impairment in the population of former teenage smokers and many of today’s finest adult minds were once young smokers. If a detrimental cognitive effect of nicotine existed in the human population, it is inconceivable that we would not already have seen extensive evidence of it from the study of smokers, non-smokers and ex-smokers over several decades." | *But this is not the main reason for doubt. Over the last 60 years, millions of adolescent nicotine users have grown up as smokers and either continue to use nicotine or have quit. The problem for the Surgeon General and others is that there is no sign of any cognitive impairment in the population of former teenage smokers and many of today’s finest adult minds were once young smokers. If a detrimental cognitive effect of nicotine existed in the human population, it is inconceivable that we would not already have seen extensive evidence of it from the study of smokers, non-smokers and ex-smokers over several decades." | ||
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