Myth: Alternative nicotine products don't help people stop smoking: Difference between revisions

Myth: Alternative nicotine products don't help people stop smoking (view source)

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→‎Combining Alternative Nicotine Products With Other Quit Smoking Strategies

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 ='''Combining Alternative Nicotine Products With Other Quit Smoking Strategies'''=
 ===2023: [https://link.springer.com/article/10.1007/s00213-023-06401-y Smoking reduction using electronic nicotine delivery systems in combination with nicotine skin patches]===
-* Jed E. Rose, Suzanne Frisbee, David Campbell, Alfred Salley, Susan Claerhout & James M. Davis Psychopharmacology (2023)
+*A critically important design component of this study was that it was not a smoking cessation treatment study, and hence smoking abstinence was not the primary outcome. Accordingly, no smoking cessation counseling was provided and smokers who expressed a desire to receive treatment for nicotine dependence were excluded from the study. Thus, the study was not expected to lead to high smoking abstinence rates but was instead designed to differentiate the pharmacologic impact of nicotine vs. no nicotine (in ENDS or patch) on smoking behavior.
-* Included here as it may have found ENDS use reduced or accidental quitters from NRT use. See section 1 here [[snw:Myth: Alternative nicotine products don't help people stop smoking|Myth: Alternative nicotine products don't help people stop smoking]].
+*...there was a strong correlation between ENDS use and decrease in self-reported cigarette consumption in week 8 (end of treatment), but only in nicotine ENDS condition...
-*Electronic nicotine delivery systems (ENDS) are used by smokers seeking to reduce combustible cigarette (CC) use, but the role of nicotine replacement vs. behavioral and sensory factors is still poorly understood. We hypothesized that providing nicotine from ENDS in addition to nicotine skin patches would promote smoking reduction relative to non-nicotine control ENDS.
+*Smoking abstinence at week 8 was also related to ENDS use in the nicotine ENDS condition only; participants who were abstinent from smoking used more nicotine pods than non-abstinent participants
-*The use of nicotine in ENDS led to significant reductions in smoking (ENDS nicotine vs. placebo difference in CO change = −9.2 ppm; 90% CI (−1.5 ppm, −16.9 ppm)) and was highly correlated with reductions in self-reported cigarettes per day (''r''=0.6). The effect of nicotine in nicotine patches was not statistically significant (patch nicotine vs. placebo difference in CO change = −0.1 ppm; 90% CI (−7.8 ppm, 7.6 ppm)).
+*The main finding of this study was that the use of nicotine vs. no nicotine in ENDS was associated with a large and statistically significant reduction in expired air CO, an objective biomarker of smoking.
-*The presence of nicotine in ENDS was associated with a large reduction in smoking. Additional studies will be needed to determine whether there may be additive effects of nicotine ENDS and nicotine patches on smoking abstinence.
-*Note: Some success has been had with NHS stop smoking services, particularly after the 20mg nicotine cap. It might be that if nicotine is restricted in ENDS then additional sources of nicotine become more important? (Sadly the NHS have not provided numbers yet, but we welcome more research and data. (ed.))
+===2023: [https://onlinelibrary.wiley.com/doi/10.1111/add.16294 E-cigarette support for smoking cessation: Identifying the effectiveness of intervention components in an on-line randomized optimization experiment]===
-===2023: [E-cigarette support for smoking cessation: Identifying the effectiveness of intervention components in an on-line randomized optimization experiment]===
 *Text-message support with tailored advice on flavour is a promising intervention combination for smokers using an e-cigarette in a quit attempt.
 *Article: [https://www.theguardian.com/society/2023/jul/16/smokers-who-get-e-cigarette-flavour-advice-more-likely-to-quit-report-finds Smokers who get e-cigarette flavour advice more likely to quit, report finds]