Nicotine - Oral Health: Difference between revisions

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=ENDS NVP ANDS E-Cigarettes=
=ENDS NVP ANDS E-Cigarettes=
===2024: [https://www.sciencedirect.com/science/article/pii/S2405844024001154 E-cigarettes and heated tobacco products impact on dental color parameters]===
*Conclusion: "Exclusive use of ECs and HTPs is associated with better dental color measurements than current smoking, suggesting that tar-free nicotine delivery technologies are unlikely to have negative effects on dental appearance."


===2023: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226679/ The risk profile of electronic nicotine delivery systems, compared to traditional cigarettes, on oral disease: a review]===
===2023: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226679/ The risk profile of electronic nicotine delivery systems, compared to traditional cigarettes, on oral disease: a review]===
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*Overall, ENDS appear to be more implant-friendly than conventional tobacco cigarettes
*Overall, ENDS appear to be more implant-friendly than conventional tobacco cigarettes
*Many of the carcinogens present in tobacco are not present in the aerosol generated by ENDS, which makes ENDS appear to be less damaging to the oral mucosa.
*Many of the carcinogens present in tobacco are not present in the aerosol generated by ENDS, which makes ENDS appear to be less damaging to the oral mucosa.
===2023: [https://link.springer.com/article/10.1007/s00784-023-05162-4 The impact of electronic and conventional cigarettes on periodontal health—a systematic review and meta-analysis]===
*"The current findings suggest that e-cigarette use might be considered a healthier alternative to cigarette smoking concerning periodontal health. Even so, harmful effects of electronic nicotine delivery system (ENDS) usage on periodontal health were seen as well. However, a definitive decision on this research question remains elusive due to the absence of randomized controlled trials."
===2023: [https://www.bsperio.org.uk/news/is-vaping-harmful-to-oral-health Is vaping harmful to oral health?]===
*"In summary, the oral health evidence supports the general public health messages and guidance on e-cigarettes. E-cigarette use is far less harmful than tobacco cigarettes, although not risk free – we will likely see oral health consequences of long-term vaping (but less than from tobacco smoking). E-cigarettes are not recommended for non-users, especially young people. For existing smokers, e-cigarettes can be an effective quit aid and dental professionals should support patients who choose to use this method of cessation."


===2022: [https://www.cdhjournal.org/issues/39-2-june-2022/1124-electronic-cigarettes-an-update-on-products-regulation-public-health-approaches-and-oral-health Electronic cigarettes: an update on products, regulation, public health approaches and oral health]===
===2022: [https://www.cdhjournal.org/issues/39-2-june-2022/1124-electronic-cigarettes-an-update-on-products-regulation-public-health-approaches-and-oral-health Electronic cigarettes: an update on products, regulation, public health approaches and oral health]===
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===2022: [https://journals.asm.org/doi/full/10.1128/mbio.00075-22 Electronic Cigarette Use Promotes a Unique Periodontal Microbiome]===
===2022: [https://journals.asm.org/doi/full/10.1128/mbio.00075-22 Electronic Cigarette Use Promotes a Unique Periodontal Microbiome]===
*Our results demonstrate that the e-cig user’s subgingival microbiome is a unique amalgamation of microbiota, containing similarities to those of both conventional smokers and nonsmokers. Due to many shared features with the conventional smoker’s microbiome and considering the widespread promotion of e-cigarettes as a “healthier” alternative to or replacement for conventional cigarettes, our results show that e-cigarette use may promote a healthier SGP [subgingival plaque] microbiome with respect to that of smokers but not compared to that found with never smoking in the first place.
*Our results demonstrate that the e-cig user’s subgingival microbiome is a unique amalgamation of microbiota, containing similarities to those of both conventional smokers and nonsmokers. Due to many shared features with the conventional smoker’s microbiome and considering the widespread promotion of e-cigarettes as a “healthier” alternative to or replacement for conventional cigarettes, our results show that e-cigarette use may promote a healthier SGP [subgingival plaque] microbiome with respect to that of smokers but not compared to that found with never smoking in the first place.
===2022: [https://www.sciencemediacentre.org/expert-reaction-to-study-looking-at-smoking-vaping-and-oral-health/ Expert reaction to study looking at smoking, vaping and oral health]===
*“They also reported an association between e-cigarette use and self-reported bleeding gums after brushing or flossing. The study authors themselves urge caution on over-interpreting this finding (see discussion section) – this may not be a direct effect of e-cigarette use and may be a result of users reducing or quitting regular cigarette smoking which is known to lead to increased bleeding. It’s an interesting finding that needs exploring in further research. 
*“The study did not find any association between e-cigarette use and any other oral health outcomes investigated (such as gum disease or tooth loss). As proposed in this paper, further follow up studies looking at the longer-term outcomes of e-cigarettes will be useful to explore this further.”


===2021: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293737/  Electronic Cigarettes and Oral Health]===
===2021: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293737/  Electronic Cigarettes and Oral Health]===
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=HnB THP HTP Heated Tobacco Products=
=HnB THP HTP Heated Tobacco Products=
===2024: [https://www.sciencedirect.com/science/article/pii/S2405844024001154 E-cigarettes and heated tobacco products impact on dental color parameters]===
*Conclusion: "Exclusive use of ECs and HTPs is associated with better dental color measurements than current smoking, suggesting that tar-free nicotine delivery technologies are unlikely to have negative effects on dental appearance."


===2022: [https://www.thejpd.org/article/S0022-3913(20)30444-3/fulltext Effects of conventional and heated tobacco product smoking on discoloration of artificial denture teeth]===
===2022: [https://www.thejpd.org/article/S0022-3913(20)30444-3/fulltext Effects of conventional and heated tobacco product smoking on discoloration of artificial denture teeth]===
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*Acknowledgement: The study was fully funded by McNeil AB who is the manufacturer of the test and control products. It was designed by McNeil AB in consultation with HW and DOM. The study was run, participants recruited, smoking cessation intervention administered and data collected by the team of research staff at the Oral Health Services Research Centre at University College Cork under the leadership of HW with consultant input from DOM. RK carried out the clinical examinations but was blinded to intervention allocation. The data were analysed by McNeil AB with input from HW and DOM. The study was externally monitored by MDS Pharma Services, UK and conducted to ICH GCP standards. The data were interpreted by HW, DOM and RK. The manuscript was drafted by HW with editorial comment from the other authors. HW decided to submit the manuscript for publication.
*Acknowledgement: The study was fully funded by McNeil AB who is the manufacturer of the test and control products. It was designed by McNeil AB in consultation with HW and DOM. The study was run, participants recruited, smoking cessation intervention administered and data collected by the team of research staff at the Oral Health Services Research Centre at University College Cork under the leadership of HW with consultant input from DOM. RK carried out the clinical examinations but was blinded to intervention allocation. The data were analysed by McNeil AB with input from HW and DOM. The study was externally monitored by MDS Pharma Services, UK and conducted to ICH GCP standards. The data were interpreted by HW, DOM and RK. The manuscript was drafted by HW with editorial comment from the other authors. HW decided to submit the manuscript for publication.
*Citation: Whelton H, Kingston R, O'Mullane D, Nilsson F. Randomized controlled trial to evaluate tooth stain reduction with nicotine replacement gum during a smoking cessation program. BMC Oral Health. 2012 Jun 13;12:13. doi: 10.1186/1472-6831-12-13. PMID: 22695211; PMCID: PMC3444372.
*Citation: Whelton H, Kingston R, O'Mullane D, Nilsson F. Randomized controlled trial to evaluate tooth stain reduction with nicotine replacement gum during a smoking cessation program. BMC Oral Health. 2012 Jun 13;12:13. doi: 10.1186/1472-6831-12-13. PMID: 22695211; PMCID: PMC3444372.
=Nicotine - Orofacial Dyskinesia=
===2012: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286320/ Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats]===
*In summary, our data show that nicotine treatment decreases haloperidol-induced VCMs [vacuous chewing movements] in an established rat model of tardive dyskinesia. The demonstration that nicotine removal leads to a return of VCMs, whereas nicotine re-exposure reduced haloperidol-induced VCMs, suggests a causal relationship. These data have clinical applications for the treatment of tardive dyskinesias associated with long-term antipsychotic treatment using nicotine.


=Nicotine Patch=
=Nicotine Patch=
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=Nicotine Pouches=
=Nicotine Pouches=
===2023: [https://www.nature.com/articles/s41415-023-6383-7 Nicotine pouches: a review for the dental team]===
*Nicotine pouches are a new product that the dental professional should be aware of, particularly in smokers and ex-smokers. They are likely to have a relatively low-risk profile, similar to other forms of orally administered nicotine; however, the prolonged and regular use may give increased risk of local oral problems. Further research is required.
===2022: [https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12885 The effect of a non-tobacco-based nicotine pouch on mucosal lesions caused by Swedish smokeless tobacco (snus)]===
*The findings of this study demonstrate that the almost complete substitution of snus with a non-tobacco-based nicotine product resulted in the gradual resolution of pre-existing oral mucosal lesions in healthy snus users over a 6-week period. Furthermore, findings showed that the investigational non-tobacco-based nicotine products do not elicit an inflammatory response in vitro.


=Snus=
=Snus=
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**also: Bartlett D. Expert view: David Bartlett. Br Dent J 2021; 231: 700.
**also: Bartlett D. Expert view: David Bartlett. Br Dent J 2021; 231: 700.
*"The authors incorrectly claim that nicotine causes a 'high risk of oral and whole-body health complications'. They cite a WHO poster which presents the effects of whole tobacco smoke on health, not the effect of nicotine. Nicotine has been used in the form of NRT for over 30 years, including in pregnant women, and is regarded as extremely safe, even for long-term use"
*"The authors incorrectly claim that nicotine causes a 'high risk of oral and whole-body health complications'. They cite a WHO poster which presents the effects of whole tobacco smoke on health, not the effect of nicotine. Nicotine has been used in the form of NRT for over 30 years, including in pregnant women, and is regarded as extremely safe, even for long-term use"
=Research Projects=
===[https://smilestudy.coehar.org/ CoEHAR's Smile Study]===


=Suggestions to add to this page=
=Suggestions to add to this page=
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