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(Cancer / Cancer Treatments) |
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==Brain Injury== | ==Brain Injury== | ||
==Cancer / Cancer Treatments== | ==Cancer / Cancer Treatments== | ||
===2020 [https://www.sciencedirect.com/science/article/abs/pii/S001448272030416X?via%3Dihub Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells]=== | |||
*Nicotine inhibits ovarian cancer cell ERK and p38 [[Abbreviations|'''MAPK''']] signaling. | |||
*Nicotine inhibits ovarian cancer proliferation and spheroid invasion. | |||
*[https://sci-hub.se/10.1016/j.yexcr.2020.112167 PDF Version] | |||
*Citation: Sarah J. Harmych, Jay Kumar, Mesa E. Bouni, Deborah N. Chadee, Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells, Experimental Cell Research, Volume 394, Issue 1, 2020, 112167, ISSN 0014-4827, doi: 10.1016/j.yexcr.2020.112167. | |||
*Acknowledgements: This work was supported by the National Institutes of Health [R15 CA199164] and [R15 CA241898] to D.N.C. | |||
*Keywords: Nicotine, Ovarian cancer, Spheroid, MAPK, Invasion | |||
===2013 [https://www.sciencedirect.com/science/article/abs/pii/S0014299913003270?via%3Dihub Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models]=== | |||
*Nicotine significantly reduced antiviral-dependent alterations of the nociceptive threshold. | |||
*Moreover, nicotine decreased neuropathic pain induced by repeated intraperitoneal administration of the anticancer agent oxaliplatin (2.4 mg/kg), lowering the hypersensitivity to mechanical and thermal stimuli. | |||
*Intraperitoneal nicotine administration controls neuropathic pain evoked by traumatic or toxic nervous system alterations. These results support the [[Abbreviations|'''nAChR''']] modulation as a possible therapeutic approach to the complex, undertreated chemotherapy-induced neuropathies. | |||
*[https://sci-hub.st/https://doi.org/10.1016/j.ejphar.2013.04.022 PDF Version] | |||
*Citation: Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Carla Ghelardini, Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models, European Journal of Pharmacology, Volume 711, Issues 1–3, 2013, Pages 87-94, ISSN 0014-2999, doi: 10.1016/j.ejphar.2013.04.022. | |||
*Acknowledgements: This work was supported by the Italian Ministry of Instruction, University and Research. | |||
*Keywords: nAChR; Dideoxycytidine; Oxaliplatin; Antiviral; Anticancer, pain, chemotherapy, nicotine, neuropathy | |||
==Cognitive / IQ== | ==Cognitive / IQ== | ||
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