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*Citation: Ikonomidis, I., Katogiannis, K., Kostelli, G., Kourea, K., Kyriakou, E., Kypraiou, A., Tsoumani, M., Andreadou, I., Lambadiari, V., Plotas, P., Thymis, I., & Tsantes, A. E. (2020). Effects of electronic cigarette on platelet and vascular function after four months of use. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111389. https://doi.org/10.1016/j.fct.2020.111389 | *Citation: Ikonomidis, I., Katogiannis, K., Kostelli, G., Kourea, K., Kyriakou, E., Kypraiou, A., Tsoumani, M., Andreadou, I., Lambadiari, V., Plotas, P., Thymis, I., & Tsantes, A. E. (2020). Effects of electronic cigarette on platelet and vascular function after four months of use. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 141, 111389. https://doi.org/10.1016/j.fct.2020.111389 | ||
===2020: Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People=== | ===2020: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509270/ Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People]=== | ||
*Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in tobacco cigarette (TC) smokers. | |||
*Impaired FMD in TC smokers is most likely attributable to non-nicotine toxicants in TC smoke, since an equivalent increase in plasma nicotine from the EC did not lead to acute impairment in FMD. | |||
Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in tobacco cigarette (TC) smokers. | *FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose"(estimated plasma nicotine) of an e-cigarette (EC), consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment. | ||
FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose"(estimated plasma nicotine) of an e-cigarette (EC), consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment. | *However, there is increasing scientific literature that supports the notion that ECs, although not harmless, may be less harmful than TC smoking for cardiovascular risk. | ||
*Acknowledgement: This work was supported by Tobacco-Related Disease Research Program Grants TRDRP 23XT-0006H (to H.R.M.), 25IR-0024H (to H.R.M.), and TRDRP 28IR-0065 (H.R.M.) and by National Institutes of Health, National Center for Advancing Translational Science UCLA CTSI Grant UL1TR001881. | |||
*Citation: Haptonstall KP, Choroomi Y, Moheimani R, Nguyen K, Tran E, Lakhani K, Ruedisueli I, Gornbein J, Middlekauff HR. Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H547-H556. doi: 10.1152/ajpheart.00307.2020. Epub 2020 Jul 31. PMID: 32734819; PMCID: PMC7509270. | |||
===2019: [https://gfn.events/documents/133/gfn_2018_reader.pdf Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence]=== <!--T:7--> | |||
===2019: Global Forum on Nicotine (GFN) The effect of electronic nicotine delivery systems (ends) and new tobacco products on the risk of cardiovascular disease in people with high tobacco dependence=== <!--T:7--> | |||
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that debunks this study: Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health | that debunks this study: [https://onlinelibrary.wiley.com/doi/10.1111/add.15067 Electronic Cigarette Use and Myocardial Infarction Among Adults in the US Population Assessment of Tobacco and Health] | ||
===2019: Is E-Cigarette Use associated with coronary heart disease and myocardial infarction?=== <!--T:11--> | ===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767743/ 2019: Is E-Cigarette Use associated with coronary heart disease and myocardial infarction?]=== <!--T:11--> | ||
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===2019: (November 15) Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes=== <!--T:13--> | ===[https://pubmed.ncbi.nlm.nih.gov/31740017/ 2019: (November 15) Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes]=== <!--T:13--> | ||
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===2019: Electronic cigarettes and cardiovascular health: what do we know so far?=== <!--T:15--> | ===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592370/ 2019: Electronic cigarettes and cardiovascular health: what do we know so far?]=== <!--T:15--> | ||
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===2017: Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation (G2) and third-generation (G3) electronic cigarette users=== <!--T:17--> | ===[https://pubmed.ncbi.nlm.nih.gov/27729564/ 2017: Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation (G2) and third-generation (G3) electronic cigarette users]=== <!--T:17--> | ||
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===2017: Electronic cigarette smoking increases of arterial stiffness and oxidative stress to a lesser extent than a single normal cigarette: an acute and chronic study=== <!--T:19--> | ===[https://pubmed.ncbi.nlm.nih.gov/29335291/ 2017: Electronic cigarette smoking increases of arterial stiffness and oxidative stress to a lesser extent than a single normal cigarette: an acute and chronic study]=== <!--T:19--> | ||
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===2016: Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture=== <!--T:21--> | ===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907307/ 2016: Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture]=== <!--T:21--> | ||
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===2013: Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report=== <!--T:23--> | ===[https://pubmed.ncbi.nlm.nih.gov/23439796/ 2013: Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: a Case Report]=== <!--T:23--> | ||
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===2012: Acute effects of electronic and tobacco cigarette smoking on complete blood count=== <!--T:25--> | ===[https://pubmed.ncbi.nlm.nih.gov/22858449/ 2012: Acute effects of electronic and tobacco cigarette smoking on complete blood count]=== <!--T:25--> | ||
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===2010: A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: nicotine delivery profile and cardiovascular and subjective effects=== <!--T:27--> | ===[https://pubmed.ncbi.nlm.nih.gov/20647410/ 2010: A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: nicotine delivery profile and cardiovascular and subjective effects]=== <!--T:27--> | ||
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===2017: Sympathomimetic Effects of Acute E‐Cigarette Use: Role of Nicotine and Non‐Nicotine Constituents=== <!--T:35--> | ===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634299/#:~:text=In%20conclusion%2C%20the%20acute%20sympathomimetic,constituents%20in%20e%E2%80%90cigarette%20aerosol. Sympathomimetic Effects of Acute E‐Cigarette Use: Role of Nicotine and Non‐Nicotine Constituents]=== <!--T:35--> | ||
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===2016: Cardiovascular toxicity of nicotine: Implications for electronic cigarette use=== <!--T:37--> | ===2016: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958544/#:~:text=Catecholamine%20release%20from%20nicotine%20could,fibrillation%20after%20experimental%20myocardial%20infarction. Cardiovascular toxicity of nicotine: Implications for electronic cigarette use]=== <!--T:37--> | ||
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