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==ENDS vs Smoking Tobacco, Heated Tobacco Product/Heat not Burn, or Nicotine Replacement Therapy== | ==ENDS vs Smoking Tobacco, Heated Tobacco Product/Heat not Burn, or Nicotine Replacement Therapy== | ||
===2020 [https://www.sciencedirect.com/science/article/pii/S0304389420314060?via%3Dihub Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]=== | |||
*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes. | |||
*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours. | |||
*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours (vapors). | |||
*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress. | |||
*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig. | |||
*[https://sci-hub.se/10.1016/j.jhazmat.2020.123417 PDF Version] | |||
*Citation: Dusautoir R, Zarcone G, Verriele M, Garc¸on G, Fronval I, Beauval N, Allorge D, Riffault V, Locoge N, Lo-Guidice J-Marc, Antherieu S, Comparison of the ´ chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials (2020), doi: 10.1016/j.jhazmat.2020.123417 | |||
*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648. | |||
===2020 [https://academic.oup.com/ntr/article/22/8/1285/5613490 Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System ]=== | |||
*The results of this study concorded with evidence that complete switching from combustible cigarettes to vapor products may reduce exposure to key carcinogens and other toxicants known to be associated with tobacco-related diseases. | |||
*[https://scholar.google.com/scholar_url?url=https://academic.oup.com/ntr/article-pdf/22/8/1285/33503504/ntz206.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=7UfSX7_HNY7gygS59oeICg&scisig=AAGBfm2cHOs4tggW6_ESThVFWjYP98IvZw PDF Version] | |||
*Citation: Joanna Jay, BA, Erika L Pfaunmiller, PhD, Norman J Huang, PhD, Gal Cohen, PhD, Donald W Graff, PharmD, Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System, Nicotine & Tobacco Research, Volume 22, Issue 8, August 2020, Pages 1285–1293, doi:10.1093/ntr/ntz206 | |||
*Acknowledgements: JJ, NJH, GC, and DWG are employees of JUUL Labs, Inc. ELP is an employee of Frontage Labs. ELP and DWG were employed by Celerion Inc. at the time the study was conducted. Celerion is a contract research organization that performs studies on tobacco and nicotine-containing products, sponsored by the pharmaceutical and tobacco industries. | |||
*Keywords: nicotine, smoking, adult, biological markers, tobacco, urine, cigarettes, smokers | |||
==ENDS (without comparison to other products)== | ==ENDS (without comparison to other products)== | ||
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