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='''Pain / Analgesic'''= <!--T:199--> | ='''Pain / Analgesic'''= <!--T:199--> | ||
===2023 [https://www.sciencedirect.com/science/article/abs/pii/S0014299923000298?via%3Dihub Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron]=== | |||
*Animal Study | |||
*Nicotine-induced antinociception was inhibited by intrathecal pre-treatment with yohimbine, an α2 adrenergic receptor antagonist. These results indicated that nicotine may suppress BCAO-induced mechanical hypersensitivity through the activation of the descending pain control system via orexin neurons. | |||
*Citation: Nakamoto, K., Matsuura, W., & Tokuyama, S. (2023). Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron. European journal of pharmacology, 175518. Advance online publication. https://doi.org/10.1016/j.ejphar.2023.175518 | |||
===2020 [https://pubmed.ncbi.nlm.nih.gov/32381373/ Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial]=== <!--T:200--> | ===2020 [https://pubmed.ncbi.nlm.nih.gov/32381373/ Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial]=== <!--T:200--> | ||
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