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**There's just one minor fact that is omitted completely in the article, as well as in all the media coverage. | **There's just one minor fact that is omitted completely in the article, as well as in all the media coverage. | ||
**That fact: All conventional cigarettes produce tobacco smoke that contains diacetyl, and the levels of diacetyl in cigarettes are a lot higher than those produced by e-cigarettes. | **That fact: All conventional cigarettes produce tobacco smoke that contains diacetyl, and the levels of diacetyl in cigarettes are a lot higher than those produced by e-cigarettes. | ||
===2019: [https://www.sciencedirect.com/science/article/pii/S0887233318307768?via%3Dihub High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate]=== | |||
*Our results clearly show a lower toxicity of e-liquids, including flavoured e-liquids, when compared to [[Abbreviations|CSC]] (cigarette smoke condensate). Typically, more than 100 times higher concentrations of [[Abbreviations|CFs]] (commercial flavoured e-liquids) are required to elicit the same response as those observed for 3R4F CSC in specific endpoints. | |||
*Flavours play a critical role in attracting, and retaining smokers to e-cigarettes. | |||
*[https://sci-hub.st/10.1016/j.tiv.2019.03.018 PDF Version] | |||
*Citation: Lukasz Czekala, Liam Simms, Matthew Stevenson, Edgar Trelles-Sticken, Paul Walker, Tanvir Walele, High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate, Toxicology in Vitro, Volume 58, 2019, Pages 86-96, ISSN 0887-2333, doi:10.1016/j.tiv.2019.03.018. | |||
*Acknowledgements: This work was funded and supported by Fontem Ventures B.V., part of Imperial Brands Group PLC. | |||
* Keywords: Flavours, In vitro, Normal Human Bronchial Epithelial cells, High Content Screening, E-liquids, Cigarette, flavor, flavoring, flavored | |||
===2019: [https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0318-2?optIn=false Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study]=== | |||
*The vast majority of flavouring (flavoring) compounds in e-cigarette liquids as reported in a recent study were present at levels far lower than needed to classify them as toxic. | |||
*[https://harmreductionjournal.biomedcentral.com/track/pdf/10.1186/s12954-019-0318-2.pdf PDF Version] | |||
*Farsalinos, K., Lagoumintzis, G. Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study. Harm Reduct J 16, 48 (2019). doi: 10.1186/s12954-019-0318-2 | |||
*Acknowledgements: The authors report no conflict of interest for the past 36 months. For the past 60 months, KF has published 2 studies funded by the non-profit association AEMSA and 1 study funded by the non-profit association Tennessee Smoke-Free Association. | |||
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*It was shocking to see a public statement reporting a case of popcorn lung disease in a patient using e-cigarettes. The title of the public release is: “Case report finds 'popcorn lung' in patient using e-cigarettes. Report points to possibility of diacetyl, a flavoring agent in e-cigarettes, to bronchiolitis obliterans syndrome” | *It was shocking to see a public statement reporting a case of popcorn lung disease in a patient using e-cigarettes. The title of the public release is: “Case report finds 'popcorn lung' in patient using e-cigarettes. Report points to possibility of diacetyl, a flavoring agent in e-cigarettes, to bronchiolitis obliterans syndrome” | ||
*The case report is NOT about popcorn lung disease. The article then goes on to explain why it can’t be popcorn lung. | *The case report is NOT about popcorn lung disease. The article then goes on to explain why it can’t be popcorn lung. | ||
===2015: [https://www.sciencedirect.com/science/article/pii/S0273230015001245?via%3Dihub An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids]=== | |||
*In vitro and Animal | |||
*Individual flavours or groups of flavours were added to the tobacco rod and the resultant smoke was analysed for priority smoke constituents and tested in several in vitro tests as well as 90-day rat inhalation studies. In general, addition of the flavours had no effect on, or reduced the levels of most of the measured smoke constituents.” | |||
*[https://sci-hub.se/10.1016/j.yrtph.2015.05.018 PDF Version] | |||
*Citation: S. Costigan, C. Meredith, An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids, Regulatory Toxicology and Pharmacology, Volume 72, Issue 2, 2015, Pages 361-369, ISSN 0273-2300, doi: 10.1016/j.yrtph.2015.05.018. | |||
*Acknowledgements: This work was joint funded by Nicoventures and British American Tobacco (BAT), and the authors are full time employees of Nicoventures and British American Tobacco (BAT). | |||
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