ENDS Flavors: Difference between revisions

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: '''FAQ: Are the flavors a threat to public health?'''
: '''FAQ: Are the flavors a threat to public health?'''
: '''FAQ: Are there any unintended consequences to banning flavored ENDS products?'''
: '''FAQ: Are there any unintended consequences to banning flavored ENDS products?'''
: '''FAQ: Does diacetyl, a flavoring agent compound in ENDS products cause Popcorn Lung?'''




=Public Health Advantages - Studies / Papers=
=Public Health Advantages / Concerns of Public Health Harms=
 
 
===2019: [https://www.cmaj.ca/content/re-vape-related-popcorn-lung-debunked-years-ago RE: Vape related "Popcorn Lung" debunked years ago]===
**There is 750x more diacetyl in a pack of cigarettes than there is in a days worth of vaping nicotine fluid, and to date we have no confirmation that smokers are getting popcorn lung.
*2015 [http://tobaccoanalysis.blogspot.com/2015/12/new-study-finds-that-average-diacetyl.html New Study Finds that Average Diacetyl Exposure from Vaping is 750 Times Lower than from Smoking]
**There's just one minor fact that is omitted completely in the article, as well as in all the media coverage.
**That fact: All conventional cigarettes produce tobacco smoke that contains diacetyl, and the levels of diacetyl in cigarettes are a lot higher than those produced by e-cigarettes.




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**Citation: Farsalinos, K. E., & Voudris, V. (2018). Do flavouring compounds contribute to aldehyde emissions in e-cigarettes? Food and Chemical Toxicology, 115, 212–217. doi:10.1016/j.fct.2018.02.059  
**Citation: Farsalinos, K. E., & Voudris, V. (2018). Do flavouring compounds contribute to aldehyde emissions in e-cigarettes? Food and Chemical Toxicology, 115, 212–217. doi:10.1016/j.fct.2018.02.059  
**Acknowledgement: The study was funded by Public Health England.  
**Acknowledgement: The study was funded by Public Health England.  
 
*2017: Follow Up: [https://pubs.acs.org/doi/10.1021/acs.est.6b06030 Comment on “Flavoring Compounds Dominate Toxic Aldehyde Production during E Cigarette Vaping”]
**We would like to point out that the finding is in a stark contrast to previous results.
**The high levels only happen under dry puff conditions, something avoided by vapers as it is very unpleasant.




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*Acknowledgement: Support for this project was provided by Grant 1 R01 DA036492 from the National Institute on Drug Abuse, and in part by General Clinical Research Center Grant M01-RR06192 from the National Institutes of Health.
*Acknowledgement: Support for this project was provided by Grant 1 R01 DA036492 from the National Institute on Drug Abuse, and in part by General Clinical Research Center Grant M01-RR06192 from the National Institutes of Health.


=Regulations or Unintended Consequences - Studies / Papers=
 
===2015: [http://www.ecigarette-research.org/research/index.php/whats-new/whatsnew-2015/234-bo Medical journal misrepresents a case of hypersensitivity pneumonitis as popcorn lung disease caused by e-cigarette]===
*It was shocking to see a public statement reporting a case of popcorn lung disease in a patient using e-cigarettes. The title of the public release is: “Case report finds 'popcorn lung' in patient using e-cigarettes. Report points to possibility of diacetyl, a flavoring agent in e-cigarettes, to bronchiolitis obliterans syndrome”
*The case report is NOT about popcorn lung disease. The article then goes on to explain why it can’t be popcorn lung.
 
 
 
=Regulations or Unintended Consequences=




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*Acknowledgement: Supported by the National Institute on Drug Abuse of the National Institutes of Health (NIH) and the Center for Tobacco Products of the U.S. Food and Drug Administration (FDA) (P50-DA-036107) for the Penn State Tobacco Center of Regulatory Science.
*Acknowledgement: Supported by the National Institute on Drug Abuse of the National Institutes of Health (NIH) and the Center for Tobacco Products of the U.S. Food and Drug Administration (FDA) (P50-DA-036107) for the Penn State Tobacco Center of Regulatory Science.


===2018 [https://www.regulations.gov/document?D=FDA-2017-N-6565-22941 Patterns of flavored e-cigarette use among adults vapers in the United States: an internet survey]===  
 
===2018: [https://www.regulations.gov/document?D=FDA-2017-N-6565-22941 Patterns of flavored e-cigarette use among adults vapers in the United States: an internet survey]===  
*Survey results submitted to the FDA
*Survey results submitted to the FDA
*In conclusion, this cross-sectional study of a very large sample of adult US e-cigarette users, most of which were former smokers, identified the importance of non-tobacco flavors in e-cigarette use initiation and sustained use, and their contribution to smoking cessation and relapse prevention. *'''This information should be considered by regulators in order to avoid unintentional adverse effects of over-restrictive regulation on e-cigarette flavors'''.
*In conclusion, this cross-sectional study of a very large sample of adult US e-cigarette users, most of which were former smokers, identified the importance of non-tobacco flavors in e-cigarette use initiation and sustained use, and their contribution to smoking cessation and relapse prevention. *'''This information should be considered by regulators in order to avoid unintentional adverse effects of over-restrictive regulation on e-cigarette flavors'''.
*[https://www.regulations.gov/contentStreamer?documentId=FDA-2017-N-6565-22941&attachmentNumber=1&contentType=pdf PDF Version]
*[https://www.regulations.gov/contentStreamer?documentId=FDA-2017-N-6565-22941&attachmentNumber=1&contentType=pdf PDF Version]
*Citation: Konstantinos Farsalinos, MD, MPH, Christopher Russell, PhD, George Lagoumintzis, PhD, Konstantinos Poulas, Submitted to: Docket No. FDA-2017 N-6565 for “Regulation of Flavors in Tobacco Products.”
*Citation: Konstantinos Farsalinos, MD, MPH, Christopher Russell, PhD, George Lagoumintzis, PhD, Konstantinos Poulas, Submitted to: Docket No. FDA-2017 N-6565 for “Regulation of Flavors in Tobacco Products.”


===2018: [https://tobaccocontrol.bmj.com/content/28/2/168 Should flavours be banned in cigarettes and e-cigarettes? Evidence on adult smokers and recent quitters from a discrete choice experiment]===
===2018: [https://tobaccocontrol.bmj.com/content/28/2/168 Should flavours be banned in cigarettes and e-cigarettes? Evidence on adult smokers and recent quitters from a discrete choice experiment]===
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=Relapse Prevention or Long Term Abstinence - Studies / Papers=
=Relapse Prevention or Long Term Abstinence=




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=Smoking Cessation - Studies / Papers=
=Smoking Cessation=




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===2019 [https://pubmed.ncbi.nlm.nih.gov/31477072/ Vaping patterns, nicotine dependence and reasons for vaping among American Indian dual users of cigarettes and electronic cigarettes]===
===2019: [https://pubmed.ncbi.nlm.nih.gov/31477072/ Vaping patterns, nicotine dependence and reasons for vaping among American Indian dual users of cigarettes and electronic cigarettes]===
*The ten-item Penn State Dependence Index (PSDI) suggested greater dependence on smoking than vaping
*The ten-item Penn State Dependence Index (PSDI) suggested greater dependence on smoking than vaping
*'''The most common reasons for vaping were to reduce smoking (79%)''', enjoyment of flavors (78%), and ability to vape where smoking is not allowed (73%). Perceptions of less harm to others (69%) or to self were the next most common (65%). Fewer than half used ECs to reduce stress, for affordability, or because others used them.
*'''The most common reasons for vaping were to reduce smoking (79%)''', enjoyment of flavors (78%), and ability to vape where smoking is not allowed (73%). Perceptions of less harm to others (69%) or to self were the next most common (65%). Fewer than half used ECs to reduce stress, for affordability, or because others used them.
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*Acknowledgement: Grants from the National Cancer Institute of the National Institutes of Health (P20CA202921 to University of Oklahoma, and 5P20CA202923 to Cherokee Nation) supported this study.
*Acknowledgement: Grants from the National Cancer Institute of the National Institutes of Health (P20CA202921 to University of Oklahoma, and 5P20CA202923 to Cherokee Nation) supported this study.


===2018 [https://academic.oup.com/ntr/article-abstract/20/8/977/4061315?redirectedFrom=fulltext Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking]===
 
===2018: [https://academic.oup.com/ntr/article-abstract/20/8/977/4061315?redirectedFrom=fulltext Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking]===
*This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. '''Vapers advised smokers to find the right combination of device, flavors and nicotine strength''', continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping.
*This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. '''Vapers advised smokers to find the right combination of device, flavors and nicotine strength''', continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping.
*[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version]
*[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version]
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*Acknowledgement: Funding for this study was provided by Nicoventures.
*Acknowledgement: Funding for this study was provided by Nicoventures.


===2017 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800112/ Differences between Dual Users and Switchers Center around Vaping Behavior and Its Experiences Rather than Beliefs and Attitudes]===
 
===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800112/ Differences between Dual Users and Switchers Center around Vaping Behavior and Its Experiences Rather than Beliefs and Attitudes]===
*To the extent that dual users substantially lower the number of cigarettes, they will reduce health risks from smoking. However, from a medical point of view, exclusive vaping is preferable to dual use;
*To the extent that dual users substantially lower the number of cigarettes, they will reduce health risks from smoking. However, from a medical point of view, exclusive vaping is preferable to dual use;
*Differences between dual users and switchers center around variables proximal to the vaping behavior and its experienced effects rather than hinging on more general vaping-related beliefs and attitudes.
*Differences between dual users and switchers center around variables proximal to the vaping behavior and its experienced effects rather than hinging on more general vaping-related beliefs and attitudes.
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*Citation: Berg CJ. Preferred flavors and reasons for e-cigarette use and discontinued use among never, current, and former smokers. Int J Public Health. 2016 Mar;61(2):225-36. doi: 10.1007/s00038-015-0764-x. Epub 2015 Nov 18. PMID: 26582009; PMCID: PMC4808473.
*Citation: Berg CJ. Preferred flavors and reasons for e-cigarette use and discontinued use among never, current, and former smokers. Int J Public Health. 2016 Mar;61(2):225-36. doi: 10.1007/s00038-015-0764-x. Epub 2015 Nov 18. PMID: 26582009; PMCID: PMC4808473.
*Acknowledgement: This research was supported by the National Cancer Institute (1K07CA139114-01A1; PI: Berg) and the Georgia Cancer Coalition (PI: Berg).
*Acknowledgement: This research was supported by the National Cancer Institute (1K07CA139114-01A1; PI: Berg) and the Georgia Cancer Coalition (PI: Berg).


===2013: [https://www.mdpi.com/1660-4601/10/12/7272/htm Impact of Flavour Variability on Electronic Cigarette Use Experience: An Internet Survey]===
===2013: [https://www.mdpi.com/1660-4601/10/12/7272/htm Impact of Flavour Variability on Electronic Cigarette Use Experience: An Internet Survey]===
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*Acknowledgement: No funding was received for this study.
*Acknowledgement: No funding was received for this study.


=Use of Flavors (Youth to Sr. Citizens) - Studies / Papers=
 
 
=Use of Flavors (Youth to Sr. Citizens)=




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at the University of Minnesota (T32HP22239).
at the University of Minnesota (T32HP22239).


=Youth - Studies / Papers=
 
 
=Youth=




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*A well researched article that touches on many of the myths and fears about youth use of flavored vapor products.
*A well researched article that touches on many of the myths and fears about youth use of flavored vapor products.
[https://www.clivebates.com/documents/Flavours20Nov2019.pdf PDF Version]
[https://www.clivebates.com/documents/Flavours20Nov2019.pdf PDF Version]


=Suggested Studies, Papers, Surveys, and Articles to Add to This Page=
=Suggested Studies, Papers, Surveys, and Articles to Add to This Page=
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