Nicotine therapeutic benefits: Difference between revisions

(2 intermediate revisions by the same user not shown)

Line 901:

**Citation: Wiersinga, W. M. (2013). Smoking and thyroid. Clinical Endocrinology, 79(2), 145–151. doi:10.1111/cen.12222

***Acknowledgement: None stated

='''HIV (human immunodeficiency virus)'''=

===2025: [https://www.sciencedirect.com/science/article/abs/pii/S0149763425003495 Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential]===

*"Approximately half of people with HIV (PWH) experience neurocognitive impairment (NCI), despite antiretroviral therapies that have turned what was formerly a death sentence to a chronic illness. No targeted treatments exist for HIV-associated NCI, impacting long-term quality of life. Smoking rates in PWH are nearly double those of the general population, and with evidence for pro-cognitive effects of nicotine, this may reflect self-medication. However, clinical studies yield inconsistent findings-some showing benefits, others reporting harm-likely due to variability in nicotine exposure methods, cognitive testing paradigms, withdrawal states, and confounding comorbidities. In contrast, animal studies offer a more controlled framework to isolate the effects of nicotine. Preclinical models suggest that nicotine may mitigate HIV-associated cognitive deficits by acting on α7 nicotinic acetylcholine receptors (nAChRs), leading to reduced neuroinflammation. These findings highlight the therapeutic potential of targeting nAChRs, though mechanisms remain incompletely understood..."

**Citation: Jha NA, Ayoub SM, Brody AL, Young JW. Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential. Neurosci Biobehav Rev. 2025 Aug 23;177:106348. doi: 10.1016/j.neubiorev.2025.106348. Epub ahead of print. PMID: 40854454.

***Acknowledgement: This work was supported by the National Institutes of Health [grant numbers: R01MH134175 (JWY), R01MH128869 (JWY), R01DA051295 (JWY)]...

===2021: [https://pmc.ncbi.nlm.nih.gov/articles/PMC11334575/ Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia]===

*However, alternative pathways with more holistic representations of molecular relationships revealed the potential of nicotine as a neuroprotective treatment. It was found that concurrent with nicotine treatment the individual inactivation of several of the intermediary molecules in the holistic pathways caused the downregulation of the HAD pathology molecules. These findings reveal that nicotine may have therapeutic properties for HAD when given alongside specific inhibitory drugs for one or more of the identified intermediary molecules.

**Citation: Krishnan, V., Vigorito, M., Kota, N.K. et al. Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia. J Neuroimmune Pharmacol 17, 487–502 (2022). https://doi.org/10.1007/s11481-021-10027-2

***Acknowledgement: This study was partially supported by National Institute of Health grants DA43448 and DA046258 to SLC.

='''Huntington’s Disease'''=

Line 1,864:

Line 1,876:

*Acknowledgements: Supported in part by grants from the Smokeless Tobacco Research Council, Inc., the Tourette Syndrome Association, and Merrell Dow Pharmaceuticals. The authors thank Roger Stuebing, B.S.M.E., M.S.I.E., and Sunny Y. Lu, M.D., Ph.D. for statistical advice and Merrell Dow Pharmaceuticals for supplying both Nicoreue® gum and placebo nicotine gum.

===~~1991~~ [https://pubmed.ncbi.nlm.nih.gov/~~1859921~~/ ~~Beneficial~~ effects of nicotine]===

='''Suggested additions to this page'''=

*~~When chronically taken~~, ~~nicotine may result in~~: ~~protection against Tourette~~'s disease (~~other diseases mentioned~~ in ~~study)~~

*[https://sci-hub.st/10.~~1111~~/j.~~1360~~-~~0443~~.~~1991~~.~~tb01810~~.~~x PDF Version~~]

===2021: [https://link.springer.com/article/10.1007/s12640-021-00375-5 Novel Pharmacotherapies in Parkinson’s Disease]===

*Citation: ~~Jarvik ME~~. ~~Beneficial effects of nicotine~~. ~~Br J Addict. 1991 May;86~~(5):~~571-5~~. ~~doi~~: 10.~~1111~~/j.~~1360~~-~~0443~~.~~1991~~.~~tb01810~~.x. ~~PMID~~: ~~1859921~~.

*[https://sci-hub.st/10.1007/s12640-021-00375-5 PDF Full paper]

*Acknowledgement: ~~Supported by U~~. C. ~~Tobacco~~-~~related Disease program~~, ~~grant # RT87 and~~ a ~~grant from~~ the ~~John D~~. ~~and Catherine T~~. ~~MacArthur Foundation~~.

===2001: [https://today.duke.edu/2001/08/mm_medicaluses.html Medical Uses for Nicotine]===

===2021: [https://pubmed.ncbi.nlm.nih.gov/33675460/ Nicotine gum enhances visual processing in healthy nonsmokers]===

===[https://www.researchgate.net/publication/325159226_Resolution_of_chronic_rhinitis_to_staphylococcus_aureus_in_a_non-smoker_who_started_to_use_glycerine_based_e-cigarettes_Antibacterial_effects_of_vaping Resolution of chronic rhinitis to staphylococcus aureus in a non-smoker who started to use glycerine based e-cigarettes: Antibacterial effects of vaping?]===

===2019: [https://medium.com/parkinsons-uk/protecting-brain-cells-the-story-of-nicotine-b3b51f5b8259 Protecting brain cells — the story of nicotine]===

*[https://web.archive.org/web/20221021040501/https://www.parkinsons.org.uk/nicotine-good-bad-and-ugly Nicotine - Good, Bad, Ugly]

===2017 [https://www.ncbi.nlm.nih.gov/pubmed/27940486 Moist smokeless tobacco (Snus) use and risk of Parkinson's disease]===

*Smoke-free nicotine appears to reduce the risk of Parkinson’s disease by 60%.

*different website same study? [Moist smokeless tobacco (Snus) use and risk of Parkinson’s disease|https://academic.oup.com/ije/article/46/3/872/2656164]

===1986: [https://pubmed.ncbi.nlm.nih.gov/3786334/ Effects of nicotine on finger tapping rate in non-smokers]===

===1996: [https://sci-hub.st/10.1093/oxfordjournals.bmb.a011533 Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious]===

===2020 [https://n.neurology.org/content/neurology/94/20/e2132.full.pdf Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors]===

===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC526783/ Nicotine as Therapy]===

=== 2021: [https://www.spektrum.de/news/kognition-nikotin-gegen-neuropsychiatrische-erkrankungen/1924141 Kognition: Nikotin gegen neuropsychiatrische Erkrankungen] (German) 'Cognition: nicotine versus neuropsychiatric disorders' ===

===Dr. Newhouse [http://mindstudy.org/news Mind Study]===

===2010 [https://pubmed.ncbi.nlm.nih.gov/20414766/ Meta-analysis of the acute effects of nicotine and smoking on human performance] and 2012 [https://n.neurology.org/content/78/2/91.short Nicotine treatment of mild cognitive impairment A 6-month double-blind pilot clinical trial]===

*Clinical studies suggest some cognitive improvements as a result of nicotine.

===2021 [https://www.dovepress.com/effectiveness-and-safety-profile-of-alternative-tobacco-and-nicotine-p-peer-reviewed-fulltext-article-JMDH Effectiveness and Safety Profile of Alternative Tobacco and Nicotine Products for Smoking Reduction and Cessation: A Systematic Review]===

===[https://docs.google.com/document/d/13-D2q1P0KpmZuoFBkKV4l9wUEQ-zcHfp6MAVJGoAaG4/edit?usp=sharing INNCO's List smoking cessation]===

Started: continue @ “Among smokers who have attempted to stop without professional support, those who use e-cigarettes are more likely to report continued abstinence than those who used a licensed NRT products [i.e., nicotine patches, gum or lozenges].”

https://onlinelibrary.wiley.com/doi/full/10.1111/add.12623

===[https://twitter.com/jkelovuori/status/1413963688709664769 Go through the links in this thread]===

===To do: Go through the references for nicotine related studies===

====2020: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404387/ Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders]====

===1989 [https://www.sciencedirect.com/science/article/abs/pii/002432058990444X?via%3Dihub Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of tourette syndrome and other motor disorders]===

@@ Line 901: / Line 901: @@
 **Citation: Wiersinga, W. M. (2013). Smoking and thyroid. Clinical Endocrinology, 79(2), 145–151. doi:10.1111/cen.12222
 ***Acknowledgement: None stated
+='''HIV (human immunodeficiency virus)'''=
+===2025: [https://www.sciencedirect.com/science/article/abs/pii/S0149763425003495 Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential]===
+*"Approximately half of people with HIV (PWH) experience neurocognitive impairment (NCI), despite antiretroviral therapies that have turned what was formerly a death sentence to a chronic illness. No targeted treatments exist for HIV-associated NCI, impacting long-term quality of life. Smoking rates in PWH are nearly double those of the general population, and with evidence for pro-cognitive effects of nicotine, this may reflect self-medication. However, clinical studies yield inconsistent findings-some showing benefits, others reporting harm-likely due to variability in nicotine exposure methods, cognitive testing paradigms, withdrawal states, and confounding comorbidities. In contrast, animal studies offer a more controlled framework to isolate the effects of nicotine. Preclinical models suggest that nicotine may mitigate HIV-associated cognitive deficits by acting on α7 nicotinic acetylcholine receptors (nAChRs), leading to reduced neuroinflammation. These findings highlight the therapeutic potential of targeting nAChRs, though mechanisms remain incompletely understood..."
+**Citation: Jha NA, Ayoub SM, Brody AL, Young JW. Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential. Neurosci Biobehav Rev. 2025 Aug 23;177:106348. doi: 10.1016/j.neubiorev.2025.106348. Epub ahead of print. PMID: 40854454.
+***Acknowledgement: This work was supported by the National Institutes of Health [grant numbers: R01MH134175 (JWY), R01MH128869 (JWY), R01DA051295 (JWY)]...
+===2021: [https://pmc.ncbi.nlm.nih.gov/articles/PMC11334575/ Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia]===
+*However, alternative pathways with more holistic representations of molecular relationships revealed the potential of nicotine as a neuroprotective treatment. It was found that concurrent with nicotine treatment the individual inactivation of several of the intermediary molecules in the holistic pathways caused the downregulation of the HAD pathology molecules. These findings reveal that nicotine may have therapeutic properties for HAD when given alongside specific inhibitory drugs for one or more of the identified intermediary molecules.
+**Citation: Krishnan, V., Vigorito, M., Kota, N.K. et al. Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia. J Neuroimmune Pharmacol 17, 487–502 (2022). https://doi.org/10.1007/s11481-021-10027-2
+***Acknowledgement: This study was partially supported by National Institute of Health grants DA43448 and DA046258 to SLC.
 ='''Huntington’s Disease'''=
@@ Line 1,864: / Line 1,876: @@
 *Acknowledgements: Supported in part by grants from the Smokeless Tobacco Research Council, Inc., the Tourette Syndrome Association, and Merrell Dow Pharmaceuticals. The authors thank Roger Stuebing, B.S.M.E., M.S.I.E., and Sunny Y. Lu, M.D., Ph.D. for statistical advice and Merrell Dow Pharmaceuticals for supplying both Nicoreue® gum and placebo nicotine gum.
-===1991 [https://pubmed.ncbi.nlm.nih.gov/1859921/ Beneficial effects of nicotine]===
+='''Suggested additions to this page'''=
-*When chronically taken, nicotine may result in: protection against Tourette's disease (other diseases mentioned in study)
-*[https://sci-hub.st/10.1111/j.1360-0443.1991.tb01810.x PDF Version]
+===2021: [https://link.springer.com/article/10.1007/s12640-021-00375-5 Novel Pharmacotherapies in Parkinson’s Disease]===
-*Citation: Jarvik ME. Beneficial effects of nicotine. Br J Addict. 1991 May;86(5):571-5. doi: 10.1111/j.1360-0443.1991.tb01810.x. PMID: 1859921.
+*[https://sci-hub.st/10.1007/s12640-021-00375-5 PDF Full paper]
-*Acknowledgement: Supported by U. C. Tobacco-related Disease program, grant # RT87 and a grant from the John D. and Catherine T. MacArthur Foundation.
+===2001: [https://today.duke.edu/2001/08/mm_medicaluses.html Medical Uses for Nicotine]===
+===2021: [https://pubmed.ncbi.nlm.nih.gov/33675460/ Nicotine gum enhances visual processing in healthy nonsmokers]===
+===[https://www.researchgate.net/publication/325159226_Resolution_of_chronic_rhinitis_to_staphylococcus_aureus_in_a_non-smoker_who_started_to_use_glycerine_based_e-cigarettes_Antibacterial_effects_of_vaping Resolution of chronic rhinitis to staphylococcus aureus in a non-smoker who started to use glycerine based e-cigarettes: Antibacterial effects of vaping?]===
+===2019: [https://medium.com/parkinsons-uk/protecting-brain-cells-the-story-of-nicotine-b3b51f5b8259 Protecting brain cells — the story of nicotine]===
+*[https://web.archive.org/web/20221021040501/https://www.parkinsons.org.uk/nicotine-good-bad-and-ugly Nicotine - Good, Bad, Ugly]
+===2017 [https://www.ncbi.nlm.nih.gov/pubmed/27940486 Moist smokeless tobacco (Snus) use and risk of Parkinson's disease]===
+*Smoke-free nicotine appears to reduce the risk of Parkinson’s disease by 60%.
+*different website same study? [Moist smokeless tobacco (Snus) use and risk of Parkinson’s disease|https://academic.oup.com/ije/article/46/3/872/2656164]
+===1986: [https://pubmed.ncbi.nlm.nih.gov/3786334/ Effects of nicotine on finger tapping rate in non-smokers]===
+===1996: [https://sci-hub.st/10.1093/oxfordjournals.bmb.a011533 Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious]===
+===2020 [https://n.neurology.org/content/neurology/94/20/e2132.full.pdf Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors]===
+===[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC526783/ Nicotine as Therapy]===
+=== 2021: [https://www.spektrum.de/news/kognition-nikotin-gegen-neuropsychiatrische-erkrankungen/1924141 Kognition: Nikotin gegen neuropsychiatrische Erkrankungen] (German)  'Cognition: nicotine versus neuropsychiatric disorders' ===
+===Dr. Newhouse [http://mindstudy.org/news Mind Study]===
+===2010 [https://pubmed.ncbi.nlm.nih.gov/20414766/ Meta-analysis of the acute effects of nicotine and smoking on human performance] and 2012 [https://n.neurology.org/content/78/2/91.short Nicotine treatment of mild cognitive impairment A 6-month double-blind pilot clinical trial]===
+*Clinical studies suggest some cognitive improvements as a result of nicotine.
+===2021 [https://www.dovepress.com/effectiveness-and-safety-profile-of-alternative-tobacco-and-nicotine-p-peer-reviewed-fulltext-article-JMDH Effectiveness and Safety Profile of Alternative Tobacco and Nicotine Products for Smoking Reduction and Cessation: A Systematic Review]===
+===[https://docs.google.com/document/d/13-D2q1P0KpmZuoFBkKV4l9wUEQ-zcHfp6MAVJGoAaG4/edit?usp=sharing INNCO's List smoking cessation]===
+Started: continue @ “Among smokers who have attempted to stop without professional support, those who use e-cigarettes are more likely to report continued abstinence than those who used a licensed NRT products [i.e., nicotine patches, gum or lozenges].”
+https://onlinelibrary.wiley.com/doi/full/10.1111/add.12623
+===[https://twitter.com/jkelovuori/status/1413963688709664769 Go through the links in this thread]===
+===To do: Go through the references for nicotine related studies===
+====2020: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404387/ Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders]====
 ===1989 [https://www.sciencedirect.com/science/article/abs/pii/002432058990444X?via%3Dihub Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of tourette syndrome and other motor disorders]===