Nicotine therapeutic benefits: Difference between revisions
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* Ruan S, Xie J, Wang L, Guo L, Li Y, Fan W, Ji R, Gong Z, Xu Y, Mao J, Xie J. Front Pharmacol. 2023 Feb 2;14:1088957. doi: 10.3389/fphar.2023.1088957. eCollection 2023. PMID: 36817162 Free PMC article. | * Ruan S, Xie J, Wang L, Guo L, Li Y, Fan W, Ji R, Gong Z, Xu Y, Mao J, Xie J. Front Pharmacol. 2023 Feb 2;14:1088957. doi: 10.3389/fphar.2023.1088957. eCollection 2023. PMID: 36817162 Free PMC article. | ||
=== 2023: [https://jamanetwork.com/journals/jamaneurology/article-abstract/2805037 Risk of Parkinson Disease Among Service Members at Marine Corps Base Camp Lejeune] === | ===2023: [https://jamanetwork.com/journals/jamaneurology/article-abstract/2805037 Risk of Parkinson Disease Among Service Members at Marine Corps Base Camp Lejeune]=== | ||
*You have to dig into text and tables to spot “Parkinson disease risk was substantially lower among Black veterans and EVER-SMOKERS (OR 0.49, 95% CI: 0.40-0.61). | |||
*Samuel M. Goldman, MD, MPH; Frances M. Weaver, PhD; Kevin T. Stroupe, PhD; et al JAMA Neurol. Published online May 15, 2023. doi:10.1001/jamaneurol.2023.1168 | |||
* | ===2023: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602090/ Butyrate Protects and Synergizes with Nicotine against Iron- and Manganese-induced Toxicities in Cell Culture]=== | ||
*In summary, our results not only support neuroprotective effects of nicotine and butyrate in countering Fe and Mn toxicities but indicate a synergistic protection by combination of the two. Moreover, distinct mechanisms of action for each metal, i.e., nicotinic receptor for nicotine and FA3R for butyrate are indicated. Further exploitation of mechanisms of action of butyrate and nicotine may provide novel targets for metal toxicities and/or amelioration of neurodegenerative diseases. | |||
* | *Citation: Tizabi Y, Getachew B, Aschner M. Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3389904. doi: 10.21203/rs.3.rs-3389904/v1. Update in: Neurotox Res. 2023 Dec 14;42(1):3. doi: 10.1007/s12640-023-00682-z. PMID: 37886507; PMCID: PMC10602090. | ||
=== 2020: [https://n.neurology.org/content/94/20/e2132 Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors] === | === 2020: [https://n.neurology.org/content/94/20/e2132 Tobacco smoking and the risk of Parkinson disease A 65-year follow-up of 30,000 male British doctors] === | ||