Nicotine therapeutic benefits: Difference between revisions

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='''Arthritis/Skeletal'''=

==Osteoarthritis==

===2019 [https://journals.aai.org/jimmunol/article/203/2/485/107400/Nicotine-Attenuates-Osteoarthritis-Pain-and-Matrix Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor]===

*In conclusion, stimulation of α7-nAChRs by nicotine attenuates MIA-induced OA pain and cartilage degradation. This protective effect of nicotine can be associated with the inhibition of MMP-9 overexpression through the PI3K/Akt/NF-κB signaling pathway. Although the use of nicotine is limited by its nonspecific effects, this study provides novel evidence supporting the future development of therapeutic strategies for inflammatory diseases via the cholinergic anti-inflammatory pathway.

**Citation: Teng P, Liu Y, Dai Y, Zhang H, Liu WT, Hu J. Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor. J Immunol. 2019 Jul 15;203(2):485-492. doi: 10.4049/jimmunol.1801513. Epub 2019 May 31. PMID: 31152077.

***This work was supported by grants from the National Natural Science Foundation of China (81373397, 81672218, and 81603092) and the Department of Science, Education, and Health Program of Jiangsu Province (QNRC 2016606 and QNRC 2016604).

==Rheumatoid arthritis (collagen-induced arthritis CIA in mice)==

===2016 [https://www.spandidos-publications.com/mmr/14/6/5057 Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration]===

*Animal study

@@ Line 226: / Line 226: @@
 ='''Arthritis/Skeletal'''=
+==Osteoarthritis==
+===2019 [https://journals.aai.org/jimmunol/article/203/2/485/107400/Nicotine-Attenuates-Osteoarthritis-Pain-and-Matrix Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor]===
+*In conclusion, stimulation of α7-nAChRs by nicotine attenuates MIA-induced OA pain and cartilage degradation. This protective effect of nicotine can be associated with the inhibition of MMP-9 overexpression through the PI3K/Akt/NF-κB signaling pathway. Although the use of nicotine is limited by its nonspecific effects, this study provides novel evidence supporting the future development of therapeutic strategies for inflammatory diseases via the cholinergic anti-inflammatory pathway.
+**Citation: Teng P, Liu Y, Dai Y, Zhang H, Liu WT, Hu J. Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor. J Immunol. 2019 Jul 15;203(2):485-492. doi: 10.4049/jimmunol.1801513. Epub 2019 May 31. PMID: 31152077.
+***This work was supported by grants from the National Natural Science Foundation of China (81373397, 81672218, and 81603092) and the Department of Science, Education, and Health Program of Jiangsu Province (QNRC 2016606 and QNRC 2016604).
+==Rheumatoid arthritis (collagen-induced arthritis CIA in mice)==
 ===2016 [https://www.spandidos-publications.com/mmr/14/6/5057 Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration]===
 *Animal study