Nicotine therapeutic benefits: Difference between revisions

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*Citation: Giovanni Ciancio, Matteo Colina, Renato La Corte, Andrea Lo Monaco, Francesco De Leonardis, Francesco Trotta, Marcello Govoni, Nicotine-patch therapy on mucocutaneous lesions of Behçet’s disease: a case series, Rheumatology, Volume 49, Issue 3, March 2010, Pages 501–504, doi: 10.1093/rheumatology/kep401

*Keywords: Behçet’s disease, Cigarette smoking, Nicotine therapy, Mucocutaneous lesions

===2007 [https://www.jidonline.org/article/S0022-202X(15)33112-2/fulltext Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease]===

*"In conclusion, we observed substantial inhibitory effects of CSE and nicotine on IL-8 and to a lesser extent on IL-6 release by human keratinocytes and HMEC-1 endothelial cells. These findings may explain the beneficial effect of smoking in BD, also because IL-8, and to some extent IL-6, are likely to induce pivotal proinflammatory signals in this disease (Lee et al., 1993). Nicotine may cause immunoregulation by affecting chemokine/cytokine production. This study also demonstrates the different behavior of cells in terms of cytokine release when stimulated with BD patients' sera compared to those of healthy individuals. The in vitro evidence of beneficial effects of nicotine in BD is fundamental to our ongoing clinical trial with nicotine transdermal patches in BD. In addition, the detected beneficial effect of biochanin A implicates this compound as a candidate for future developments in aphthae treatment. The development of topical nicotinic cholinergic receptor subtype-specific agonists is likely to exhibit beneficial effects on skin and mucosae without inducing systemic adverse effects."

**Citation: Kalayciyan A, Orawa H, Fimmel S, Perschel FH, González JB, Fitzner RG, Orfanos CE, Zouboulis CC. Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease. J Invest Dermatol. 2007 Jan;127(1):81-9. doi: 10.1038/sj.jid.5700492. Epub 2006 Sep 28. PMID: 17008886.

***Acknowledgement: Dr Kalayciyan was supported by a grant of the Berlin Foundation for Dermatology. The research project was supported by the Deutsches Register Morbus Adamantiades–Behçet e.V.

===2000 [https://www.nejm.org/doi/10.1056/NEJM200012143432418?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed Nicotine Patches for Aphthous Ulcers Due to Behçet's Syndrome]===

@@ Line 310: / Line 310: @@
 *Citation: Giovanni Ciancio, Matteo Colina, Renato La Corte, Andrea Lo Monaco, Francesco De Leonardis, Francesco Trotta, Marcello Govoni, Nicotine-patch therapy on mucocutaneous lesions of Behçet’s disease: a case series, Rheumatology, Volume 49, Issue 3, March 2010, Pages 501–504, doi: 10.1093/rheumatology/kep401
 *Keywords: Behçet’s disease, Cigarette smoking, Nicotine therapy, Mucocutaneous lesions
+===2007 [https://www.jidonline.org/article/S0022-202X(15)33112-2/fulltext Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease]===
+*"In conclusion, we observed substantial inhibitory effects of CSE and nicotine on IL-8 and to a lesser extent on IL-6 release by human keratinocytes and HMEC-1 endothelial cells. These findings may explain the beneficial effect of smoking in BD, also because IL-8, and to some extent IL-6, are likely to induce pivotal proinflammatory signals in this disease (Lee et al., 1993). Nicotine may cause immunoregulation by affecting chemokine/cytokine production. This study also demonstrates the different behavior of cells in terms of cytokine release when stimulated with BD patients' sera compared to those of healthy individuals. The in vitro evidence of beneficial effects of nicotine in BD is fundamental to our ongoing clinical trial with nicotine transdermal patches in BD. In addition, the detected beneficial effect of biochanin A implicates this compound as a candidate for future developments in aphthae treatment. The development of topical nicotinic cholinergic receptor subtype-specific agonists is likely to exhibit beneficial effects on skin and mucosae without inducing systemic adverse effects."
+**Citation: Kalayciyan A, Orawa H, Fimmel S, Perschel FH, González JB, Fitzner RG, Orfanos CE, Zouboulis CC. Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease. J Invest Dermatol. 2007 Jan;127(1):81-9. doi: 10.1038/sj.jid.5700492. Epub 2006 Sep 28. PMID: 17008886.
+***Acknowledgement: Dr Kalayciyan was supported by a grant of the Berlin Foundation for Dermatology. The research project was supported by the Deutsches Register Morbus Adamantiades–Behçet e.V.
 ===2000 [https://www.nejm.org/doi/10.1056/NEJM200012143432418?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed Nicotine Patches for Aphthous Ulcers Due to Behçet's Syndrome]===