Nicotine therapeutic benefits: Difference between revisions

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='''Allergies / Hayfever / Histamines'''=

===2020 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203434/ Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation]===

*Animal Study

*In this study, the effect of environmental tobacco smoke (ETS) on allergen-immunized and allergen-specific Th2 cell-transferred murine eosinophilic inflammation models and that of cigarette smoke extract (CSE) and nicotine on allergen-induced Th2 cell proliferation and interleukin (IL)-4 production were investigated.

*In summary, ETS suppressed allergen-induced nasal responses including NHR by inhibiting allergen-specific Th2 cell responses. Although our present findings do not deny harmful effects of cigarette smoking, nicotine as a component of ETS may be a target to treat Th2-mediated allergic diseases, including allergic rhinitis (AR).

**Citation: Nishimura T, Kaminuma O, Saeki M, Kitamura N, Mori A, Hiroi T. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation. Asia Pac Allergy. 2020 Apr 27;10(2):e18. doi: 10.5415/apallergy.2020.10.e18. PMID: 32411583; PMCID: PMC7203434.

***Acknowledgement: This work was supported in part by funding from the Smoking Research Foundation provided to Osamu Kaminuma.

===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440386/ Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium]===

*Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.

**Citation: Skaaby T, Taylor AE, Jacobsen RK, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w. PMID: 28533558; PMCID: PMC5440386.

***~~Acknowledgements~~: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).

***Acknowledgement: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).

===2009: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614131/?ref=blog.lucy.co Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens]===

@@ Line 120: / Line 120: @@
 ='''Allergies / Hayfever / Histamines'''=
+===2020 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203434/ Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation]===
+*Animal Study
+*In this study, the effect of environmental tobacco smoke (ETS) on allergen-immunized and allergen-specific Th2 cell-transferred murine eosinophilic inflammation models and that of cigarette smoke extract (CSE) and nicotine on allergen-induced Th2 cell proliferation and interleukin (IL)-4 production were investigated.
+*In summary, ETS suppressed allergen-induced nasal responses including NHR by inhibiting allergen-specific Th2 cell responses. Although our present findings do not deny harmful effects of cigarette smoking, nicotine as a component of ETS may be a target to treat Th2-mediated allergic diseases, including allergic rhinitis (AR).
+**Citation: Nishimura T, Kaminuma O, Saeki M, Kitamura N, Mori A, Hiroi T. Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation. Asia Pac Allergy. 2020 Apr 27;10(2):e18. doi: 10.5415/apallergy.2020.10.e18. PMID: 32411583; PMCID: PMC7203434.
+***Acknowledgement: This work was supported in part by funding from the Smoking Research Foundation provided to Osamu Kaminuma.
 ===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440386/ Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium]===
 *Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
 **Citation: Skaaby T, Taylor AE, Jacobsen RK, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w. PMID: 28533558; PMCID: PMC5440386.
-***Acknowledgements: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).
+***Acknowledgement: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).
 ===2009: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614131/?ref=blog.lucy.co Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens]===