Nicotine therapeutic benefits: Difference between revisions

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**Citation: Chaoran Ma, Samantha Molsberry, Yanping Li, Michael Schwarzschild, Alberto Ascherio, Xiang Gao, Dietary nicotine intake and risk of Parkinson disease: a prospective study, The American Journal of Clinical Nutrition, Volume 112, Issue 4, October 2020, Pages 1080–1087, doi: 10.1093/ajcn/nqaa186

***Acknowledgements: Supported by National Institute of Neurological Disorders and Stroke at the NIH grant 1R03NS093245-01A1 (to XG). The Nurses’ Health Study is supported by the NIH through grant UM1 CA186107. The Health Professionals Follow-up Study cohort is supported by the NIH through grant U01 CA167552.

===2018 [https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6]===

*Animal study

*The reduced prevalence of Parkinson’s disease in tobacco users is a fascinating phenomenon that is not understood. This study suggests a mechanistic explanation for how tobacco users are protected from Parkinson’s and how the tobacco component nicotine confers neuroprotection; more specifically, nicotine suppresses SIRT6 which confers resistance to neuron and cell death. Few effective treatments exist that prevent neuron death for those suffering from Parkinson’s and other neurodegenerative disorders. The identification of SIRT6 as potentially pathogenic and as a therapeutic target for suppression opens a novel line of research for the treatment of neurodegeneration.

**Citation: Nicholatos, J.W., Francisco, A.B., Bender, C.A. et al. Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6. acta neuropathol commun 6, 120 (2018). https://doi.org/10.1186/s40478-018-0625-y

***Acknowledgement: S.L. and J.W.N. were in part supported by a grant from American Federation for Aging Research (AFAR, grant # 2015–030). S.L. received seed grant funding from the Cornell University Center for Vertebrate Genomics. J.W.N. was supported by a Glenn/AFAR Scholarship for Research in the Biology of Aging.

===2017 [https://academic.oup.com/ije/article/46/3/872/2656164 Moist smokeless tobacco (Snus) use and risk of Parkinson's disease]===

@@ Line 1,152: / Line 1,152: @@
 **Citation: Chaoran Ma, Samantha Molsberry, Yanping Li, Michael Schwarzschild, Alberto Ascherio, Xiang Gao, Dietary nicotine intake and risk of Parkinson disease: a prospective study, The American Journal of Clinical Nutrition, Volume 112, Issue 4, October 2020, Pages 1080–1087, doi: 10.1093/ajcn/nqaa186
 ***Acknowledgements: Supported by National Institute of Neurological Disorders and Stroke at the NIH grant 1R03NS093245-01A1 (to XG). The Nurses’ Health Study is supported by the NIH through grant UM1 CA186107. The Health Professionals Follow-up Study cohort is supported by the NIH through grant U01 CA167552.
+===2018 [https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6]===
+*Animal study
+*The reduced prevalence of Parkinson’s disease in tobacco users is a fascinating phenomenon that is not understood. This study suggests a mechanistic explanation for how tobacco users are protected from Parkinson’s and how the tobacco component nicotine confers neuroprotection; more specifically, nicotine suppresses SIRT6 which confers resistance to neuron and cell death. Few effective treatments exist that prevent neuron death for those suffering from Parkinson’s and other neurodegenerative disorders. The identification of SIRT6 as potentially pathogenic and as a therapeutic target for suppression opens a novel line of research for the treatment of neurodegeneration.
+**Citation: Nicholatos, J.W., Francisco, A.B., Bender, C.A. et al. Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6. acta neuropathol commun 6, 120 (2018). https://doi.org/10.1186/s40478-018-0625-y
+***Acknowledgement: S.L. and J.W.N. were in part supported by a grant from American Federation for Aging Research (AFAR, grant # 2015–030). S.L. received seed grant funding from the Cornell University Center for Vertebrate Genomics. J.W.N. was supported by a Glenn/AFAR Scholarship for Research in the Biology of Aging.
 ===2017 [https://academic.oup.com/ije/article/46/3/872/2656164 Moist smokeless tobacco (Snus) use and risk of Parkinson's disease]===