Nicotine therapeutic benefits: Difference between revisions

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**Citation: Nakamoto, K., Matsuura, W., & Tokuyama, S. (2023). Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron. European journal of pharmacology, 175518. Advance online publication. https://doi.org/10.1016/j.ejphar.2023.175518

***Acknowledgement: This work was supported by the Smoking Research Foundation (FP01807092).

===2023: [https://pubmed.ncbi.nlm.nih.gov/36947193/ Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials]===

*Perioperative use of NP significantly improved postoperative pain, even when opioids were administered or prescribed. Nevertheless, the clinical relevance should be interpreted with caution, owing to the effect sizes of the summary measures and methodological issues. The analgesic potential of NP as an adjuvant therapy to regulate pain and acute inflammation may offer certain clinical advantages, thus warranting further investigation.

**Citation: da Silva Barbirato D, de Melo Vasconcelos AF, Dantas de Moraes SL, Pellizzer EP, do Egito Vasconcelos BC. Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials. Eur J Clin Pharmacol. 2023 May;79(5):589-607. doi: 10.1007/s00228-023-03475-7. Epub 2023 Mar 22. PMID: 36947193.

***Acknowledgement: Paywalled, can't access

===2020 [https://pubmed.ncbi.nlm.nih.gov/32381373/ Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial]===

@@ Line 1,291: / Line 1,291: @@
 **Citation: Nakamoto, K., Matsuura, W., & Tokuyama, S. (2023). Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron. European journal of pharmacology, 175518. Advance online publication. https://doi.org/10.1016/j.ejphar.2023.175518
 ***Acknowledgement: This work was supported by the Smoking Research Foundation (FP01807092).
+===2023: [https://pubmed.ncbi.nlm.nih.gov/36947193/ Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials]===
+*Perioperative use of NP significantly improved postoperative pain, even when opioids were administered or prescribed. Nevertheless, the clinical relevance should be interpreted with caution, owing to the effect sizes of the summary measures and methodological issues. The analgesic potential of NP as an adjuvant therapy to regulate pain and acute inflammation may offer certain clinical advantages, thus warranting further investigation.
+**Citation: da Silva Barbirato D, de Melo Vasconcelos AF, Dantas de Moraes SL, Pellizzer EP, do Egito Vasconcelos BC. Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials. Eur J Clin Pharmacol. 2023 May;79(5):589-607. doi: 10.1007/s00228-023-03475-7. Epub 2023 Mar 22. PMID: 36947193.
+***Acknowledgement: Paywalled, can't access
 ===2020 [https://pubmed.ncbi.nlm.nih.gov/32381373/ Effectiveness of nicotine patch for the control of pain, oedema, and trismus following third molar surgery: a randomized clinical trial]===