Myth: Alternative nicotine products don't help people stop smoking: Difference between revisions
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*Our results suggest that nicotine-ECs may be more effective in smoking cessation when compared to placebo ECs or NRT. | *Our results suggest that nicotine-ECs may be more effective in smoking cessation when compared to placebo ECs or NRT. | ||
*[https://sci-hub.st/10.1093/ntr/ntaa181 PDF Version] | *[https://sci-hub.st/10.1093/ntr/ntaa181 PDF Version] | ||
===2019: [https://www.nejm.org/doi/10.1056/NEJMoa1808779 A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy]=== | |||
*A total of 886 participants underwent randomization. The 1-year abstinence rate was 18.0% in the e-cigarette group, as compared with 9.9% in the nicotine-replacement group (relative risk, 1.83; 95% confidence interval [CI], 1.30 to 2.58; P<0.001). Among participants with 1-year abstinence, those in the e-cigarette group were more likely than those in the nicotine-replacement group to use their assigned product at 52 weeks (80% [63 of 79 participants] vs. 9% [4 of 44 participants]). Overall, throat or mouth irritation was reported more frequently in the e-cigarette group (65.3%, vs. 51.2% in the nicotine-replacement group) and nausea more frequently in the nicotine-replacement group (37.9%, vs. 31.3% in the e-cigarette group). The e-cigarette group reported greater declines in the incidence of cough and phlegm production from baseline to 52 weeks than did the nicotine-replacement group (relative risk for cough, 0.8; 95% CI, 0.6 to 0.9; relative risk for phlegm, 0.7; 95% CI, 0.6 to 0.9). There were no significant between-group differences in the incidence of wheezing or shortness of breath. | |||
*Conclusion: E-cigarettes were more effective for smoking cessation than nicotine-replacement therapy, when both products were accompanied by behavioral support. | |||
*[https://www.nejm.org/doi/pdf/10.1056/NEJMoa1808779 PDF Version] | |||
===2019: [https://www.journalslibrary.nihr.ac.uk/hta/hta23430#/abstract E-cigarettes compared with nicotine replacement therapy within the UK Stop Smoking Services: the TEC RCT]=== | ===2019: [https://www.journalslibrary.nihr.ac.uk/hta/hta23430#/abstract E-cigarettes compared with nicotine replacement therapy within the UK Stop Smoking Services: the TEC RCT]=== | ||