Smokeless Tobacco - HnB: Difference between revisions

Line 19:

===[https://twitter.com/ManuelPeitsch/status/1380128227973341189 Twitter thread with HnB info]===

===2020 [https://www.sciencedirect.com/science/article/pii/S0304389420314060?via%3Dihub Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===

*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes.

*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours.

*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours (vapors).

*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress.

*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig.

*[https://sci-hub.se/10.1016/j.jhazmat.2020.123417 PDF Version]

*Citation: Dusautoir R, Zarcone G, Verriele M, Garc¸on G, Fronval I, Beauval N, Allorge D, Riffault V, Locoge N, Lo-Guidice J-Marc, Antherieu S, Comparison of the ´ chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials (2020), doi: 10.1016/j.jhazmat.2020.123417

*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648.

===2018 [https://pubmed.ncbi.nlm.nih.gov/29920842/ Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette]===

*The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette.

*[https://sci-hub.se/10.1111/add.14365 PDF Version]

*Citation: Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette. Addiction. 2018 Nov;113(11):2099-2106. doi: 10.1111/add.14365. Epub 2018 Jul 10. PMID: 29920842.

*Keywords: Carbonyls; electronic cigarettes; harm reduction; heated tobacco products; nicotine; smoking.

===[https://www.sciencedirect.com/science/article/pii/S2214750021000147 Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco products]===

=More Information=

*Click on the category link below for more studies by topic on Smokeless Tobacco and Nicotine.

[[Category:Studies, Surveys, and Papers]]

@@ Line 19: / Line 19: @@
 ===[https://twitter.com/ManuelPeitsch/status/1380128227973341189 Twitter thread with HnB info]===
+===2020 [https://www.sciencedirect.com/science/article/pii/S0304389420314060?via%3Dihub Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]===
+*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes.
+*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours.
+*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours (vapors).
+*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress.
+*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig.
+*[https://sci-hub.se/10.1016/j.jhazmat.2020.123417 PDF Version]
+*Citation:  Dusautoir R, Zarcone G, Verriele M, Garc¸on G, Fronval I, Beauval N, Allorge D, Riffault V, Locoge N, Lo-Guidice J-Marc, Antherieu S, Comparison of the ´ chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials (2020), doi: 10.1016/j.jhazmat.2020.123417
+*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648.
+===2018 [https://pubmed.ncbi.nlm.nih.gov/29920842/ Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette]===
+*The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette.
+*[https://sci-hub.se/10.1111/add.14365 PDF Version]
+*Citation: Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette. Addiction. 2018 Nov;113(11):2099-2106. doi: 10.1111/add.14365. Epub 2018 Jul 10. PMID: 29920842.
+*Keywords: Carbonyls; electronic cigarettes; harm reduction; heated tobacco products; nicotine; smoking.
+===[https://www.sciencedirect.com/science/article/pii/S2214750021000147 Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco products]===
 =More Information=
 *Click on the category link below for more studies by topic on Smokeless Tobacco and Nicotine.
 [[Category:Studies, Surveys, and Papers]]

Smokeless Tobacco - HnB: Difference between revisions

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