Nicotine - Retracted Studies, Papers, and Articles: Difference between revisions
Jump to navigation
Jump to search
| Line 209: | Line 209: | ||
*"It is literally true that they "find no evidence...", but that is because this study is completely ill-suited to drawing any policy conclusions about e-cigarettes and COPD. Despite hinting at the limitations of cross-sectional data, the authors draw a negative-sounding conclusion without addressing the key question of how respiratory health changes for a given smoker who uses e-cigarettes to quit or cut down once they are ill from smoking or as a way of preventing COPD." (Bates) | *"It is literally true that they "find no evidence...", but that is because this study is completely ill-suited to drawing any policy conclusions about e-cigarettes and COPD. Despite hinting at the limitations of cross-sectional data, the authors draw a negative-sounding conclusion without addressing the key question of how respiratory health changes for a given smoker who uses e-cigarettes to quit or cut down once they are ill from smoking or as a way of preventing COPD." (Bates) | ||
*Referring to: Bowler RP, Hansel NN, Jacobson S, Graham Barr R, Make BJ, Han MK, O'Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, Woodruff PG, Drummond MB; for COPDGene and SPIROMICS Investigators. Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. J Gen Intern Med. 2017 Dec;32(12):1315-1322. doi: 10.1007/s11606-017-4150-7. Epub 2017 Sep 7. PMID: 28884423; PMCID: PMC5698219. | *Referring to: Bowler RP, Hansel NN, Jacobson S, Graham Barr R, Make BJ, Han MK, O'Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, Woodruff PG, Drummond MB; for COPDGene and SPIROMICS Investigators. Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. J Gen Intern Med. 2017 Dec;32(12):1315-1322. doi: 10.1007/s11606-017-4150-7. Epub 2017 Sep 7. PMID: 28884423; PMCID: PMC5698219. | ||
===2016: "Popcorn Lung" RE: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892932/ Comment on “Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes”]=== | |||
*"Over the past five years, we have published the results of several studies in which diacetyl and 2,3-pentanedione levels were measured in various consumer products..." | |||
*"..."hundreds of consumer products (e.g., tea, coffee, citrus juices, butter) contain naturally occurring diacetyl and 2,3-pentanedione...several studies have shown that airborne diketones associated with these products are easily detectable..." | |||
*"Unless one assumes that unflavored coffee beans pose a serious risk of “popcorn lung,” a rare and oftentimes lethal disease, then one should agree that exposures to airborne diketone levels above the NIOSH and ACGIH OELs are not necessarily indicative of respiratory risk." | |||
*"Similarly, we measured concentrations of naturally occurring diacetyl and 2,3-pentanedione in mainstream cigarette smoke at levels (200–400 ppm and 30–50 ppm, respectively) that are hundreds of thousands of times higher than the NIOSH and ACGIH OELs, yet cigarette smoking is not associated with “popcorn lung”. Also, as others have noted, diketone exposures from traditional cigarettes are higher than those associated with e-cigarette use, hence switching from tobacco to e-cigarettes may result in reduced diketone exposure." | |||
*"Ironically, suggesting that diketone levels in e-cigarettes are potentially dangerous could actually lead to higher diketone exposures in the smoking population if smokers decide not to switch to e-cigarettes due to as yet unfounded health concerns." | |||
*Referring to: Allen JG, Flanigan SS, LeBlanc M, Vallarino J, MacNaughton P, Stewart JH, Christiani DC. Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes. Environ Health Perspect. 2016 Jun;124(6):733-9. doi: 10.1289/ehp.1510185. Epub 2015 Dec 8. PMID: 26642857; PMCID: PMC4892929. | |||
===2016: RE: [https://pubpeer.com/publications/566A631490E2222E1E6DE4F44B6989 Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner]=== | ===2016: RE: [https://pubpeer.com/publications/566A631490E2222E1E6DE4F44B6989 Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner]=== | ||