Nicotine therapeutic benefits: Difference between revisions

Line 1,130:

*"Seizure frequency improved in a single patient with refractory ADSHE after nicotine transdermal patches treatment.(108) The favorable effect of nicotine on seizure frequency was also described in 9 of 22 patients from two European ADSHE families carrying CHRNA4 mutations.(109) Considering the role of the cholinergic system in arousal regulatory processes, these observations suggested a possible link between nicotine defect, alteration of arousal regulation and seizures in SHE/ADSHE patients. However, despite the reported positive effect of nicotine in reducing seizure frequency, a case–control family study, did not find a higher tendency to smoke tobacco in SHE patients and their relatives compared with the control cases.(110)

**Citation: Menghi V, Bisulli F, Tinuper P, Nobili L. Sleep-related hypermotor epilepsy: prevalence, impact and management strategies. Nat Sci Sleep. 2018 Oct 10;10:317-326. doi: 10.2147/NSS.S152624. PMID: 30349413; PMCID: PMC6186898.

===2015 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433466/ Pearls & Oy-sters: A case of refractory nocturnal seizures]===

*"Due to frequent seizures, there was a paucity of slow-wave sleep and complete absence of REM sleep. On the second day of her hospital admission, a 7-mg nicotine patch was applied about 2–3 hours before bedtime. There was almost complete resolution of clinical and electrical events. The duration of slow-wave sleep increased and REM sleep was recorded. The next morning, the patient felt refreshed and less anxious."

**Citation: Pavlakis PP, Douglass LM. Pearls & Oysters: A case of refractory nocturnal seizures: Putting out fires without smoke. Neurology. 2015 May 5;84(18):e134-6. doi: 10.1212/WNL.0000000000001539. PMID: 25941204; PMCID: PMC4433466.

===2012 [https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2012.03715.x Resolution of epileptic encephalopathy following treatment with transdermal nicotine]===

@@ Line 1,130: / Line 1,130: @@
 *"Seizure frequency improved in a single patient with refractory ADSHE after nicotine transdermal patches treatment.(108) The favorable effect of nicotine on seizure frequency was also described in 9 of 22 patients from two European ADSHE families carrying CHRNA4 mutations.(109) Considering the role of the cholinergic system in arousal regulatory processes, these observations suggested a possible link between nicotine defect, alteration of arousal regulation and seizures in SHE/ADSHE patients. However, despite the reported positive effect of nicotine in reducing seizure frequency, a case–control family study, did not find a higher tendency to smoke tobacco in SHE patients and their relatives compared with the control cases.(110)
 **Citation: Menghi V, Bisulli F, Tinuper P, Nobili L. Sleep-related hypermotor epilepsy: prevalence, impact and management strategies. Nat Sci Sleep. 2018 Oct 10;10:317-326. doi: 10.2147/NSS.S152624. PMID: 30349413; PMCID: PMC6186898.
+===2015 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433466/ Pearls & Oy-sters: A case of refractory nocturnal seizures]===
+*"Due to frequent seizures, there was a paucity of slow-wave sleep and complete absence of REM sleep. On the second day of her hospital admission, a 7-mg nicotine patch was applied about 2–3 hours before bedtime. There was almost complete resolution of clinical and electrical events. The duration of slow-wave sleep increased and REM sleep was recorded. The next morning, the patient felt refreshed and less anxious."
+**Citation: Pavlakis PP, Douglass LM. Pearls & Oysters: A case of refractory nocturnal seizures: Putting out fires without smoke. Neurology. 2015 May 5;84(18):e134-6. doi: 10.1212/WNL.0000000000001539. PMID: 25941204; PMCID: PMC4433466.
 ===2012 [https://onlinelibrary.wiley.com/doi/full/10.1111/j.1528-1167.2012.03715.x Resolution of epileptic encephalopathy following treatment with transdermal nicotine]===