Nicotine therapeutic benefits: Difference between revisions

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**Citation: Skaaby T, Taylor AE, Jacobsen RK, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w. PMID: 28533558; PMCID: PMC5440386.

***Acknowledgement: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).

===2014: [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085888 Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model]===

*Animal study

*In this study, nicotine treatment significantly ameliorated FA [Food Allergy], mainly due to the suppression of upregulated mucosal immune responses via α7 nAChRs on immune cells. Therefore, the therapeutic effects of nicotine and GTS-21 on the FA model raise the possibility that a strategy for drug discovery against FA by targeting α7 nAChRs could potentially have therapeutic benefits.

**Citation: Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M. Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888. PMID: 24454942; PMCID: PMC3894205.

===2009: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614131/?ref=blog.lucy.co Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens]===

@@ Line 132: / Line 132: @@
 **Citation: Skaaby T, Taylor AE, Jacobsen RK, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017 May 22;7(1):2224. doi: 10.1038/s41598-017-01977-w. PMID: 28533558; PMCID: PMC5440386.
 ***Acknowledgement: This work was supported by the Medical Research Council (grant numbers: MR/J01351X/1, MC_UU_12013/6). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk).
+===2014: [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085888 Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model]===
+*Animal study
+*In this study, nicotine treatment significantly ameliorated FA [Food Allergy], mainly due to the suppression of upregulated mucosal immune responses via α7 nAChRs on immune cells. Therefore, the therapeutic effects of nicotine and GTS-21 on the FA model raise the possibility that a strategy for drug discovery against FA by targeting α7 nAChRs could potentially have therapeutic benefits.
+**Citation: Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M. Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model. PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888. PMID: 24454942; PMCID: PMC3894205.
 ===2009: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614131/?ref=blog.lucy.co Nicotine Primarily Suppresses Lung Th2 but not Goblet Cell and Muscle Cell Responses to Allergens]===