Nicotine therapeutic benefits: Difference between revisions
Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model |
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=== 2024: [https://pubmed.ncbi.nlm.nih.gov/38430248/ Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease] === | === 2024: [https://pubmed.ncbi.nlm.nih.gov/38430248/ Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease] === | ||
*Animal study (worms with humanised neurons) | |||
* This study examines whether nicotine helps transgenic C. elegans PD models. According to numerous studies, nicotine enhances synaptic plasticity and dopaminergic neuronal survival. Upgrades UPS pathways, increases autophagy, and decreases oxidative stress and mitochondrial dysfunction. | *This study examines whether nicotine helps transgenic C. elegans PD models. According to numerous studies, nicotine enhances synaptic plasticity and dopaminergic neuronal survival. Upgrades UPS pathways, increases autophagy, and decreases oxidative stress and mitochondrial dysfunction. | ||
* At 100, 150, and 200 µM nicotine levels, worms showed reduced α-Syn aggregation, repaired DA neurotoxicity after 6-OHDA intoxication, increased lifetime, and reduced lipofuscin accumulation. Furthermore, nicotine triggered autophagy and UPS. | *At 100, 150, and 200 µM nicotine levels, worms showed reduced α-Syn aggregation, repaired DA neurotoxicity after 6-OHDA intoxication, increased lifetime, and reduced lipofuscin accumulation. Furthermore, nicotine triggered autophagy and UPS. | ||
* We revealed nicotine's potential as a UPS and autophagy activator to prevent PD and other neurodegenerative diseases. | *We revealed nicotine's potential as a UPS and autophagy activator to prevent PD and other neurodegenerative diseases. | ||
* ''Note: highly technical brain biochemistry, appears to be important however (ed.)'' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586504/ Paper on the UPS and it's purpose] for info. | *''Note: highly technical brain biochemistry, appears to be important however (ed.)'' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586504/ Paper on the UPS and it's purpose] for info. | ||
* | **Citation: Ullah I, Uddin S, Zhao L, Wang X, Li H. Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease. Exp Brain Res. 2024 Apr;242(4):971-986. doi: 10.1007/s00221-023-06765-9. Epub 2024 Mar 2. PMID: 38430248. | ||
* | ***Acknowledgement: This study was supported by the Special International Cooperation Project of the Ministry of Science and Technology (2012DFA30480); National Natural Science Foundation of China (No. 81403145); Natural Science Foundation of Gansu Province (No. 20JR10RA602); Fundamental Research Funds for the Central Universities of China (lzujbky—2017-206, lzujbky-2018-136); Science and Technology Cooperation Program of Gansu Academy of Sciences (grant number 2019HZ-02); Program of Lanzhou Science and Technology Foundation (Grant number 2010-1-154). Major science and technology project of Gansu province (23ZDFA013), Natural Science Foundation of Gansu province (20JR10RA602). | ||
=== 2023: [https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease] === | === 2023: [https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease] === | ||