Nicotine therapeutic benefits: Difference between revisions

Line 691:

*In conclusion, nicotine significantly and dose-dependently attenuated 3-NP-induced striatal lesions and behavioral deficits in rats. The protective effect of nicotine may be attributed to its ability of restoring striatal DA levels in 3-NP intoxicated rats.

*[https://sci-hub.se/10.1016/j.brainresbull.2005.06.024 PDF Version]

*Citation: Tariq M, Khan HA, Elfaki I, Al Deeb S, Al Moutaery K. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res Bull. 2005 Sep 30;67(1-2):161-8. doi: 10.1016/j.brainresbull.2005.06.024. PMID: 16140176.

**Citation: Tariq M, Khan HA, Elfaki I, Al Deeb S, Al Moutaery K. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res Bull. 2005 Sep 30;67(1-2):161-8. doi: 10.1016/j.brainresbull.2005.06.024. PMID: 16140176.

<br>

='''Hypersensitivity Pneumonitis / Extrinsic Allergic Alveolitis'''=

*[https://www.nhlbi.nih.gov/health/hypersensitivity-pneumonitis Hypersensitivity pneumonitis] is a rare immune system disorder that affects the lungs. This disease is also called bird or pigeon fancier’s lung, farmer’s lung, hot tub lung, cheese worker's lung, Bagassosis, mushroom worker's lung, malt worker's lung, or humidifier lung.

*[https://www.ncbi.nlm.nih.gov/books/NBK499918/ Hypersensitivity pneumonitis] (HP) classified as an interstitial lung disease is characterized by a complex immunological reaction of the lung parenchyma in response to repetitive inhalation of a sensitized allergen.

===2023: [https://www.ncbi.nlm.nih.gov/books/NBK499918/ Hypersensitivity Pneumonitis]===

*Cigarette smoking seems to protect from developing clinically significant HP likely due to nicotine inhibiting macrophage activation and lymphocyte proliferation.

*However, smokers who develop HP have been shown to have a more severe course and higher mortality.

**Citation: Chandra D, Cherian SV. Hypersensitivity Pneumonitis. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499918/

===2002: [https://www.atsjournals.org/doi/10.1164/rccm.200210-1154OC Inhibitory Effect of Nicotine on Experimental Hypersensitivity Pneumonitis In Vivo and In Vitro]===

*Animal study

*Results of this study show that nicotine reduces the alveolar inflammatory response to S. rectivirgula antigen and affects some AM (stimulated with LPS or S. rectivirgula) functions in vitro. This influence could be, at least in part, responsible for the protection that smokers have against development of HP. Because nicotine is effective in the treatment of ulcerative colitis, it could also be of interest in the treatment of HP and other pulmonary inflammatory diseases.

**Citation: Blanchet MR, Israël-Assayag E, Cormier Y. Inhibitory effect of nicotine on experimental hypersensitivity pneumonitis in vivo and in vitro. Am J Respir Crit Care Med. 2004 Apr 15;169(8):903-9. doi: 10.1164/rccm.200210-1154OC. Epub 2003 Dec 30. PMID: 14701707.

<br>

='''Inflammation'''=

@@ Line 691: / Line 691: @@
 *In conclusion, nicotine significantly and dose-dependently attenuated 3-NP-induced striatal lesions and behavioral deficits in rats. The protective effect of nicotine may be attributed to its ability of restoring striatal DA levels in 3-NP intoxicated rats.
 *[https://sci-hub.se/10.1016/j.brainresbull.2005.06.024 PDF Version]
-*Citation: Tariq M, Khan HA, Elfaki I, Al Deeb S, Al Moutaery K. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res Bull. 2005 Sep 30;67(1-2):161-8. doi: 10.1016/j.brainresbull.2005.06.024. PMID: 16140176.
+**Citation: Tariq M, Khan HA, Elfaki I, Al Deeb S, Al Moutaery K. Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res Bull. 2005 Sep 30;67(1-2):161-8. doi: 10.1016/j.brainresbull.2005.06.024. PMID: 16140176.
 <br>
+='''Hypersensitivity Pneumonitis / Extrinsic Allergic Alveolitis'''=
+*[https://www.nhlbi.nih.gov/health/hypersensitivity-pneumonitis Hypersensitivity pneumonitis] is a rare immune system disorder that affects the lungs. This disease is also called bird or pigeon fancier’s lung, farmer’s lung, hot tub lung, cheese worker's lung, Bagassosis, mushroom worker's lung, malt worker's lung, or humidifier lung.
+*[https://www.ncbi.nlm.nih.gov/books/NBK499918/ Hypersensitivity pneumonitis] (HP) classified as an interstitial lung disease is characterized by a complex immunological reaction of the lung parenchyma in response to repetitive inhalation of a sensitized allergen.
+===2023: [https://www.ncbi.nlm.nih.gov/books/NBK499918/ Hypersensitivity Pneumonitis]===
+*Cigarette smoking seems to protect from developing clinically significant HP likely due to nicotine inhibiting macrophage activation and lymphocyte proliferation.
+*However, smokers who develop HP have been shown to have a more severe course and higher mortality.
+**Citation: Chandra D, Cherian SV. Hypersensitivity Pneumonitis. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499918/
+===2002: [https://www.atsjournals.org/doi/10.1164/rccm.200210-1154OC Inhibitory Effect of Nicotine on Experimental Hypersensitivity Pneumonitis In Vivo and In Vitro]===
+*Animal study
+*Results of this study show that nicotine reduces the alveolar inflammatory response to S. rectivirgula antigen and affects some AM (stimulated with LPS or S. rectivirgula) functions in vitro. This influence could be, at least in part, responsible for the protection that smokers have against development of HP. Because nicotine is effective in the treatment of ulcerative colitis, it could also be of interest in the treatment of HP and other pulmonary inflammatory diseases.
+**Citation: Blanchet MR, Israël-Assayag E, Cormier Y. Inhibitory effect of nicotine on experimental hypersensitivity pneumonitis in vivo and in vitro. Am J Respir Crit Care Med. 2004 Apr 15;169(8):903-9. doi: 10.1164/rccm.200210-1154OC. Epub 2003 Dec 30. PMID: 14701707.
+<br>
 ='''Inflammation'''=