Nicotine therapeutic benefits: Difference between revisions

Line 386:

<br>

='''Brain ~~Injury / Disease~~'''=

='''Brain Injuries, Strokes, Brain Diseases'''=

===2025: [https://pubmed.ncbi.nlm.nih.gov/39921606/ The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier]===

*Animal Study

*The study demonstrates that nicotine at low concentrations exerts neuro-protective effects by supporting the integrity of BBB and subsequent endothelial viability after ischemic stroke. This finding suggests that targeting the BBB, especially endothelial cells, with nicotine treatment is a promising therapeutic strategy for brain injury after ischemic stroke.

**Citation: Pang Q, Yan X, Chen Z, Yun L, Qian J, Dong Z, Wang M, Deng W, Fu Y, Hai T, Chen Z, Rong X. The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier. Nicotine Tob Res. 2025 Feb 8:ntaf034. doi: 10.1093/ntr/ntaf034. Epub ahead of print. PMID: 39921606.

***Acknowledgement: Paywalled, unable to access

===2024: [https://www.sciencedirect.com/science/article/pii/S0014488624002723 Acute nicotine exposure attenuates neurological deficits, ischemic injury and brain inflammatory responses and restores hippocampal long-term potentiation in ischemic stroke followed by lipopolysaccharide-induced sepsis-like state]===

*Animal Study

*Taken together, these findings indicate that acute nicotine exposure enhances functional stroke recovery. Future studies will have to evaluate the effects of (1) chronic nicotine exposure, a clinically relevant vascular risk factor, and (2) the cessation of nicotine exposure, which is widely recommended post-stroke, but might have detrimental effects in the early stroke recovery phase.

**Citation: Abbaspour S, Fahanik-Babaei J, Adeli S, Hermann DM, Sardari M. Acute nicotine exposure attenuates neurological deficits, ischemic injury and brain inflammatory responses and restores hippocampal long-term potentiation in ischemic stroke followed by lipopolysaccharide-induced sepsis-like state. Exp Neurol. 2024 Sep 13;382:114946. doi: 10.1016/j.expneurol.2024.114946. Epub ahead of print. PMID: 39278587.

***Funding: None

===2024: [https://pubmed.ncbi.nlm.nih.gov/38698493/ Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury]===

Line 392:

Line 404:

*Conclusioin: "Post-injury chronic nicotine exposure via vaping facilitates recovery of sensorimotor function by upregulating neuroprotective mBDNF/TrkB/Akt/Erk signalling. These findings suggest potential neuroprotective properties of nicotine despite its highly addictive nature. Thus, understanding the multifaceted effects of chronic nicotine exposure on TBI-associated symptoms is crucial for paving the way for informed and properly managed therapeutic interventions."

===2004 [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===

===2004: [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===

*Several studies have shown that nicotine treatment can attenuate cognitive deficits produced by medial septal lesions, lesions of the nucleus basalis, and traumatic brain injury.

*[https://sci-hub.st/10.1196/annals.1332.019 PDF Version]

@@ Line 386: / Line 386: @@
 <br>
-='''Brain Injury / Disease'''=
+='''Brain Injuries, Strokes, Brain Diseases'''=
+===2025: [https://pubmed.ncbi.nlm.nih.gov/39921606/ The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier]===
+*Animal Study
+*The study demonstrates that nicotine at low concentrations exerts neuro-protective effects by supporting the integrity of BBB and subsequent endothelial viability after ischemic stroke. This finding suggests that targeting the BBB, especially endothelial cells, with nicotine treatment is a promising therapeutic strategy for brain injury after ischemic stroke.
+**Citation: Pang Q, Yan X, Chen Z, Yun L, Qian J, Dong Z, Wang M, Deng W, Fu Y, Hai T, Chen Z, Rong X. The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier. Nicotine Tob Res. 2025 Feb 8:ntaf034. doi: 10.1093/ntr/ntaf034. Epub ahead of print. PMID: 39921606.
+***Acknowledgement: Paywalled, unable to access
+===2024: [https://www.sciencedirect.com/science/article/pii/S0014488624002723 Acute nicotine exposure attenuates neurological deficits, ischemic injury and brain inflammatory responses and restores hippocampal long-term potentiation in ischemic stroke followed by lipopolysaccharide-induced sepsis-like state]===
+*Animal Study
+*Taken together, these findings indicate that acute nicotine exposure enhances functional stroke recovery. Future studies will have to evaluate the effects of (1) chronic nicotine exposure, a clinically relevant vascular risk factor, and (2) the cessation of nicotine exposure, which is widely recommended post-stroke, but might have detrimental effects in the early stroke recovery phase.
+**Citation: Abbaspour S, Fahanik-Babaei J, Adeli S, Hermann DM, Sardari M. Acute nicotine exposure attenuates neurological deficits, ischemic injury and brain inflammatory responses and restores hippocampal long-term potentiation in ischemic stroke followed by lipopolysaccharide-induced sepsis-like state. Exp Neurol. 2024 Sep 13;382:114946. doi: 10.1016/j.expneurol.2024.114946. Epub ahead of print. PMID: 39278587.
+***Funding: None
 ===2024: [https://pubmed.ncbi.nlm.nih.gov/38698493/ Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury]===
@@ Line 392: / Line 404: @@
 *Conclusioin: "Post-injury chronic nicotine exposure via vaping facilitates recovery of sensorimotor function by upregulating neuroprotective mBDNF/TrkB/Akt/Erk signalling. These findings suggest potential neuroprotective properties of nicotine despite its highly addictive nature. Thus, understanding the multifaceted effects of chronic nicotine exposure on TBI-associated symptoms is crucial for paving the way for informed and properly managed therapeutic interventions."
-===2004 [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===
+===2004: [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===
 *Several studies have shown that nicotine treatment can attenuate cognitive deficits produced by medial septal lesions, lesions of the nucleus basalis, and traumatic brain injury.
 *[https://sci-hub.st/10.1196/annals.1332.019 PDF Version]