Nicotine therapeutic benefits: Difference between revisions

Line 403:

*Animal study

*Conclusioin: "Post-injury chronic nicotine exposure via vaping facilitates recovery of sensorimotor function by upregulating neuroprotective mBDNF/TrkB/Akt/Erk signalling. These findings suggest potential neuroprotective properties of nicotine despite its highly addictive nature. Thus, understanding the multifaceted effects of chronic nicotine exposure on TBI-associated symptoms is crucial for paving the way for informed and properly managed therapeutic interventions."

**Citation: Wang D, Li X, Li W, Duong T, Wang H, Kleschevnikova N, Patel HH, Breen E, Powell S, Wang S, Head BP. Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury. Br J Pharmacol. 2024 Sep;181(17):3082-3097. doi: 10.1111/bph.16395. Epub 2024 May 2. PMID: 38698493.

***Acknowledgement: H. H. P. and B. P. H. hold equity and are non-paid consultants with Eikonoklastes Therapeutics LLC. Funding information: (TRDRP 2020 T31IR1834 to BPH, VA Merit BX003671 and VA RCS BX006318 to BPH, AL210059 to BPH, Craig H. Neilsen Foundation 886964 to SW and BX005229 to HHP).

===2004: [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===

@@ Line 403: / Line 403: @@
 *Animal study
 *Conclusioin: "Post-injury chronic nicotine exposure via vaping facilitates recovery of sensorimotor function by upregulating neuroprotective mBDNF/TrkB/Akt/Erk signalling. These findings suggest potential neuroprotective properties of nicotine despite its highly addictive nature. Thus, understanding the multifaceted effects of chronic nicotine exposure on TBI-associated symptoms is crucial for paving the way for informed and properly managed therapeutic interventions."
+**Citation: Wang D, Li X, Li W, Duong T, Wang H, Kleschevnikova N, Patel HH, Breen E, Powell S, Wang S, Head BP. Nicotine inhalant via E-cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF-TrkB signalling in traumatic brain injury. Br J Pharmacol. 2024 Sep;181(17):3082-3097. doi: 10.1111/bph.16395. Epub 2024 May 2. PMID: 38698493.
+***Acknowledgement: H. H. P. and B. P. H. hold equity and are non-paid consultants with Eikonoklastes Therapeutics LLC. Funding information: (TRDRP 2020 T31IR1834 to BPH, VA Merit BX003671 and VA RCS BX006318 to BPH, AL210059 to BPH, Craig H. Neilsen Foundation 886964 to SW and BX005229 to HHP).
 ===2004: [https://pubmed.ncbi.nlm.nih.gov/15681815/ Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease]===