Nicotine therapeutic benefits: Difference between revisions

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**Citation: Ullah I, Uddin S, Zhao L, Wang X, Li H. Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease. Exp Brain Res. 2024 Apr;242(4):971-986. doi: 10.1007/s00221-023-06765-9. Epub 2024 Mar 2. PMID: 38430248.

***Acknowledgement: This study was supported by the Special International Cooperation Project of the Ministry of Science and Technology (2012DFA30480); National Natural Science Foundation of China (No. 81403145); Natural Science Foundation of Gansu Province (No. 20JR10RA602); Fundamental Research Funds for the Central Universities of China (lzujbky—2017-206, lzujbky-2018-136); Science and Technology Cooperation Program of Gansu Academy of Sciences (grant number 2019HZ-02); Program of Lanzhou Science and Technology Foundation (Grant number 2010-1-154). Major science and technology project of Gansu province (23ZDFA013), Natural Science Foundation of Gansu province (20JR10RA602).

===2024: [https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1427314/full The double-edged nature of nicotine: toxicities and therapeutic potentials]===

*Review includes human and animal studies.

*"Nicotine has been associated with positive effects on cognition and inflammation, which may benefit individuals with neurological and immune system disorders. As a stimulant, nicotine can bind to the acetylcholine receptors on neurons to promote the release of dopamine and alleviate various neurological diseases. Anti-inflammatory effects against some diseases are associated with the cholinergic anti-inflammatory pathway. Nicotine reduces the release of various inflammatory cytokines by binding to the macrophage surface receptors."

*"Nicotine can extensively improve cognition, which has long attracted the interest of researchers. This section introduces the therapeutic effects of nicotine on Alzheimer’s disease (AD), Parkinson’s disease (PD), schizophrenia, attention-deficit/hyperactivity disorder (ADHD), and major depressive disorder (MDD)."

*"Inflammation involves multiple genes and signaling pathways. In addition, it promotes the occurrence and development of various diseases to varying degrees. Nicotine plays an active role in various immune disorders because of its broad anti-inflammatory properties. This section describes the therapeutic effects of nicotine in rheumatoid arthritis (RA), OA, sepsis, endotoxemia, ulcerative colitis (UC), and myocarditis."

**Citation: Cao, Y., Sun, J., Wang, X., Zhang, X., Tian, H., Huang, L., Huang, Z., Zhang, Y., Zhang, J., Li, L., & Zhou, S. (2024). The double-edged nature of nicotine: Toxicities and therapeutic potentials. Frontiers in Pharmacology, 15, 1427314. https://doi.org/10.3389/fphar.2024.1427314

***Acknowledgement: This work was financially supported by the Technology Project of Anhui Zhongyan Industry Co., Ltd. (2022156), Science and Technology Projects of State Tobacco Monopoly Administration (110202201046XX-05), Startup Program of XMU and Fundamental Research Funds for the Central Universities. Authors YC, XW, XZ, HT, YZ, JZ, and SZ were employed China Tobacco Anhui Industrial Co., Ltd.

=== 2023: [https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease] ===

@@ Line 1,289: / Line 1,289: @@
 **Citation: Ullah I, Uddin S, Zhao L, Wang X, Li H. Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson's disease. Exp Brain Res. 2024 Apr;242(4):971-986. doi: 10.1007/s00221-023-06765-9. Epub 2024 Mar 2. PMID: 38430248.
 ***Acknowledgement: This study was supported by the Special International Cooperation Project of the Ministry of Science and Technology (2012DFA30480); National Natural Science Foundation of China (No. 81403145); Natural Science Foundation of Gansu Province (No. 20JR10RA602); Fundamental Research Funds for the Central Universities of China (lzujbky—2017-206, lzujbky-2018-136); Science and Technology Cooperation Program of Gansu Academy of Sciences (grant number 2019HZ-02); Program of Lanzhou Science and Technology Foundation (Grant number 2010-1-154). Major science and technology project of Gansu province (23ZDFA013), Natural Science Foundation of Gansu province (20JR10RA602).
+===2024: [https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1427314/full The double-edged nature of nicotine: toxicities and therapeutic potentials]===
+*Review includes human and animal studies.
+*"Nicotine has been associated with positive effects on cognition and inflammation, which may benefit individuals with neurological and immune system disorders. As a stimulant, nicotine can bind to the acetylcholine receptors on neurons to promote the release of dopamine and alleviate various neurological diseases. Anti-inflammatory effects against some diseases are associated with the cholinergic anti-inflammatory pathway. Nicotine reduces the release of various inflammatory cytokines by binding to the macrophage surface receptors."
+*"Nicotine can extensively improve cognition, which has long attracted the interest of researchers. This section introduces the therapeutic effects of nicotine on Alzheimer’s disease (AD), Parkinson’s disease (PD), schizophrenia, attention-deficit/hyperactivity disorder (ADHD), and major depressive disorder (MDD)."
+*"Inflammation involves multiple genes and signaling pathways. In addition, it promotes the occurrence and development of various diseases to varying degrees. Nicotine plays an active role in various immune disorders because of its broad anti-inflammatory properties. This section describes the therapeutic effects of nicotine in rheumatoid arthritis (RA), OA, sepsis, endotoxemia, ulcerative colitis (UC), and myocarditis."
+**Citation: Cao, Y., Sun, J., Wang, X., Zhang, X., Tian, H., Huang, L., Huang, Z., Zhang, Y., Zhang, J., Li, L., & Zhou, S. (2024). The double-edged nature of nicotine: Toxicities and therapeutic potentials. Frontiers in Pharmacology, 15, 1427314. https://doi.org/10.3389/fphar.2024.1427314
+***Acknowledgement: This work was financially supported by the Technology Project of Anhui Zhongyan Industry Co., Ltd. (2022156), Science and Technology Projects of State Tobacco Monopoly Administration (110202201046XX-05), Startup Program of XMU and Fundamental Research Funds for the Central Universities. Authors YC, XW, XZ, HT, YZ, JZ, and SZ were employed China Tobacco Anhui Industrial Co., Ltd.
 === 2023: [https://www.frontiersin.org/articles/10.3389/fnagi.2023.1223310/full Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease] ===