Nicotine therapeutic benefits: Difference between revisions

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* Published online on: March 25, 2021 Molecular Medicine Reports <nowiki>https://doi.org/10.3892/mmr.2021.12037</nowiki> Article Number: 398

* Author: Ahmad Alhowail

===2021: [https://www.sciencedirect.com/science/article/abs/pii/S1001841721007804 Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS]===

*Animal study

*Exposure to nicotine mainly altered the secretion of serotonin, kynurenic acid, choline and acetylcholine of HT22 cells to improve hippocampal dependent cognition, and the change are closely related to the dose and duration of exposure.

**Citation: Chen Z, Fu L, Liu X-A, Yang Z, Li W, Li F, Luo Q. Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS. Chin Chem Lett. 2022;33(6):3101–5.

***Acknowledgement: This work was financially supported by the National Natural Science Foundation of China (No. 22076197), the Scientific Instrument Developing Project of the Chinese Academy of Sciences (No. YJKYYQ20200034), Shenzhen Engineering Laboratory of Single-molecule Detection and Instrument Development (No. XMHT20190204002), Shenzhen Science and Technology Innovation Commission (No. JCYJ20200109115405930), Basic and Applied Basic Research Foundation of Guangdong Province (No. 2020B1515120080).

*Article: [https://medicalxpress.com/news/2021-10-reveal-nicotine-hippocampal-dependent-cognition.html Researchers reveal how nicotine influences hippocampal-dependent cognition] "These results suggested the acute exposure to nicotine was beneficial to protect the neurons, especially cognitive enhancement, and the elevated picolinic acid continually protected neuronal cognitive function after nicotine withdrawal. Furthermore, the dynamic alterations of neurotransmitter metabolism induced by nicotine might be a possible protective mechanism of nicotine on hippocampal dependent cognition."

===2020 [https://www.sciencedirect.com/science/article/abs/pii/S0306452220304723?via%3Dihub Effects of Nicotine on Task Switching and Distraction in Non-smokers. An fMRI Study]===

@@ Line 553: / Line 553: @@
 * Published online on: March 25, 2021 Molecular Medicine Reports  <nowiki>https://doi.org/10.3892/mmr.2021.12037</nowiki> Article Number: 398
 * Author: Ahmad Alhowail
+===2021: [https://www.sciencedirect.com/science/article/abs/pii/S1001841721007804 Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS]===
+*Animal study
+*Exposure to nicotine mainly altered the secretion of serotonin, kynurenic acid, choline and acetylcholine of HT22 cells to improve hippocampal dependent cognition, and the change are closely related to the dose and duration of exposure.
+**Citation: Chen Z, Fu L, Liu X-A, Yang Z, Li W, Li F, Luo Q. Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS. Chin Chem Lett. 2022;33(6):3101–5.
+***Acknowledgement: This work was financially supported by the National Natural Science Foundation of China (No. 22076197), the Scientific Instrument Developing Project of the Chinese Academy of Sciences (No. YJKYYQ20200034), Shenzhen Engineering Laboratory of Single-molecule Detection and Instrument Development (No. XMHT20190204002), Shenzhen Science and Technology Innovation Commission (No. JCYJ20200109115405930), Basic and Applied Basic Research Foundation of Guangdong Province (No. 2020B1515120080).
+*Article: [https://medicalxpress.com/news/2021-10-reveal-nicotine-hippocampal-dependent-cognition.html Researchers reveal how nicotine influences hippocampal-dependent cognition] "These results suggested the acute exposure to nicotine was beneficial to protect the neurons, especially cognitive enhancement, and the elevated picolinic acid continually protected neuronal cognitive function after nicotine withdrawal. Furthermore, the dynamic alterations of neurotransmitter metabolism induced by nicotine might be a possible protective mechanism of nicotine on hippocampal dependent cognition."
 ===2020 [https://www.sciencedirect.com/science/article/abs/pii/S0306452220304723?via%3Dihub Effects of Nicotine on Task Switching and Distraction in Non-smokers. An fMRI Study]===