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*This page is for referencing possible therapeutic (medicinal) '''benefits''' of nicotine. | *This page is for referencing possible therapeutic (medicinal) '''benefits''' of nicotine. | ||
==Addiction (Nicotine)== | ==Addiction / Abuse Liability (Nicotine)== | ||
===2013 [https://www.federalregister.gov/documents/2013/04/02/2013-07528/modifications-to-labeling-of-nicotine-replacement-therapy-products-for-over-the-counter-human-use Modifications To Labeling of Nicotine Replacement Therapy Products for Over-the-Counter Human Use]=== | ===2013 [https://www.federalregister.gov/documents/2013/04/02/2013-07528/modifications-to-labeling-of-nicotine-replacement-therapy-products-for-over-the-counter-human-use Modifications To Labeling of Nicotine Replacement Therapy Products for Over-the-Counter Human Use]=== | ||
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*[https://www.govinfo.gov/content/pkg/FR-2013-04-02/pdf/2013-07528.pdf PDF Version] | *[https://www.govinfo.gov/content/pkg/FR-2013-04-02/pdf/2013-07528.pdf PDF Version] | ||
*Citation: Food and Drug Administration, 78 FR 19718 | *Citation: Food and Drug Administration, 78 FR 19718 | ||
===2012 [https://academic.oup.com/ntr/article-abstract/14/1/75/1047894?redirectedFrom=fulltext Determinants of Tobacco Use and Renaming the FTND to the Fagerström Test for Cigarette Dependence]=== | ===2012 [https://academic.oup.com/ntr/article-abstract/14/1/75/1047894?redirectedFrom=fulltext Determinants of Tobacco Use and Renaming the FTND to the Fagerström Test for Cigarette Dependence]=== | ||
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*Citation: Karl Fagerström, Ph.D., Determinants of Tobacco Use and Renaming the FTND to the Fagerström Test for Cigarette Dependence, Nicotine & Tobacco Research, Volume 14, Issue 1, January 2012, Pages 75–78, doi: 10.1093/ntr/ntr137 | *Citation: Karl Fagerström, Ph.D., Determinants of Tobacco Use and Renaming the FTND to the Fagerström Test for Cigarette Dependence, Nicotine & Tobacco Research, Volume 14, Issue 1, January 2012, Pages 75–78, doi: 10.1093/ntr/ntr137 | ||
===2002 [https://pubmed.ncbi.nlm.nih.gov/12175452/ Flavor improvement does not increase abuse liability of nicotine chewing gum]=== | |||
*Mint-flavored nicotine gum was rated as more palatable than the original nicotine gum, but the improvement in flavor did not increase abuse liability in adults (22 – 50 years old) or young adults (18 –21 years old). | |||
*[https://sci-hub.se/10.1016/s0091-3057(02)00723-2 PDF Version] | |||
*Citation: Houtsmuller EJ, Fant RV, Eissenberg TE, Henningfield JE, Stitzer ML. Flavor improvement does not increase abuse liability of nicotine chewing gum. Pharmacol Biochem Behav. 2002 Jun;72(3):559-68. doi: 10.1016/s0091-3057(02)00723-2. PMID: 12175452. | |||
*Acknowledgement: This study was supported by SmithKline Beecham Consumer Healthcare. | |||
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==Addiction (Nicotine with the use or abuse of recreational substances)== | ==Addiction (Nicotine with the use or abuse of recreational substances)== | ||
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==Smoking Cessation / Preventing Relapse (All non-NRT nicotine products)== | ==Smoking Cessation / Preventing Relapse (All non-NRT nicotine products)== | ||
===Resource Doc: [https://docs.google.com/document/d/13-D2q1P0KpmZuoFBkKV4l9wUEQ-zcHfp6MAVJGoAaG4/edit?usp=sharing INNCO - Myth of the month: Ecigs and snus don’t help smokers quit]=== | |||
*Links and conclusions of studies formatted to fit the character limits on Twitter | |||
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*[https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6946a4-H.pdf PDF Version] | *[https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6946a4-H.pdf PDF Version] | ||
*Citation: Cornelius ME, Wang TW, Jamal A, Loretan CG, Neff LJ. Tobacco Product Use Among Adults — United States, 2019. MMWR Morb Mortal Wkly Rep 2020;69:1736–1742. DOI:10.15585/mmwr.mm6946a4 | *Citation: Cornelius ME, Wang TW, Jamal A, Loretan CG, Neff LJ. Tobacco Product Use Among Adults — United States, 2019. MMWR Morb Mortal Wkly Rep 2020;69:1736–1742. DOI:10.15585/mmwr.mm6946a4 | ||
===2019: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876707/ E-Cigarettes and Smoking Cessation in Smokers With Chronic Conditions]=== | |||
*At a population level, e-cigarette use by smokers with chronic medical conditions is associated with more quitting activity and smoking abstinence. | |||
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876707/pdf/nihms-1539531.pdf PDF Version] | |||
*Citation: Kalkhoran S, Chang Y, Rigotti NA. E-cigarettes and Smoking Cessation in Smokers With Chronic Conditions. Am J Prev Med. 2019;57(6):786-791. doi:10.1016/j.amepre.2019.08.017 | |||
*Acknowledgement: This study was supported by the National Heart, Lung, and Blood Institute of the NIH (K23HL136854 to Dr. Kalkhoran). | |||
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===2018 [https://academic.oup.com/ntr/article-abstract/20/8/977/4061315?redirectedFrom=fulltext Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking]=== | ===2018: [https://academic.oup.com/ntr/article-abstract/20/8/977/4061315?redirectedFrom=fulltext Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking]=== | ||
*This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. Vapers advised smokers to find the right combination of device, flavors and nicotine strength, continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping. | *This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. Vapers advised smokers to find the right combination of device, flavors and nicotine strength, continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping. | ||
*[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version] | *[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version] | ||
*Citation: Christopher Russell, PhD, Tiffany Dickson, MSc, Neil McKeganey, PhD, Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking, Nicotine & Tobacco Research, Volume 20, Issue 8, August 2018, Pages 977–984, doi: 10.1093/ntr/ntx176 | *Citation: Christopher Russell, PhD, Tiffany Dickson, MSc, Neil McKeganey, PhD, Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking, Nicotine & Tobacco Research, Volume 20, Issue 8, August 2018, Pages 977–984, doi: 10.1093/ntr/ntx176 | ||
*Acknowledgement: Funding for this study was provided by Nicoventures. | *Acknowledgement: Funding for this study was provided by Nicoventures. | ||
===2018: [https://tobaccocontrol.bmj.com/content/28/1/42 E-cigarette initiation and associated changes in smoking cessation and reduction: the Population Assessment of Tobacco and Health Study, 2013–2015]=== | |||
*Daily e-cigarette initiators were more likely to have quit smoking cigarettes or reduced use compared with non-users. However, less frequent e-cigarette use was not associated with cigarette cessation/reduction. These results suggest incorporating frequency of e-cigarette use is important for developing a more thorough understanding of the association between e-cigarette use and cigarette cessation. | |||
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/early/2018/03/24/tobaccocontrol-2017-054108.full.pdf PDF Version] | |||
*Citation: Berry KM, Reynolds LM, Collins JM, et alE-cigarette initiation and associated changes in smoking cessation and reduction: the Population Assessment of Tobacco and Health Study, 2013–2015Tobacco Control 2019;28:42-49. | |||
*Acknowledgement: Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health and the Center for Tobacco Products under Award Number P50HL120163. | |||
===2018: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751520/ E-cigarette Usage Is Associated With Increased Past-12-Month Quit Attempts and Successful Smoking Cessation in Two US Population–Based Surveys]=== | |||
*Compared with 2006, past-12-month quit attempts and smoking cessation increased among adults aged 25–44 in recent years. Current e-cigarette use was associated with increased past-12-month quit attempts and successful smoking cessation among established smokers. These findings are relevant to future tobacco policy decisions. | |||
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751520/pdf/nty211.pdf PDF Version] | |||
*Citation: Johnson L, Ma Y, Fisher SL, et al. E-cigarette Usage Is Associated With Increased Past-12-Month Quit Attempts and Successful Smoking Cessation in Two US Population-Based Surveys. Nicotine Tob Res. 2019;21(10):1331-1338. doi:10.1093/ntr/nty211 | |||
*Acknowledgement: Research reported in this paper was supported by National Institute on Drug Abuse (NIDA) grants R01DA036583 (LJB), R01DA042195 (RAG), R01DA038076 (LSC), R21DA033827 (RCC), and K12DA041449 (ATR); National Cancer Institute (NCI) grants U19CA203654 (LJB), P30CA091842 (LJB), and P30CA091842-16S2 (LSC); National Heart, Lung, and Blood Institute (NHLBI) grant R01HL109031 (TBB), National Institute on Alcohol Abuse and Alcoholism grant R21AA024888 (SMH), National Center For Advancing Translational Sciences grant TL1TR002344 (LJ), a grant from the Foundation for Barnes-Jewish Hospital (ATR), and by Grant 2015215 from the Doris Duke Charitable Foundation (SMH). | |||
===2017: [https://www.bmj.com/content/358/bmj.j3262 E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys]=== | |||
*This study, based on the largest representative sample of e-cigarette users to date, provides a strong case that e-cigarette use was associated with an increase in smoking cessation at the population level. We found that e-cigarette use was associated with an increased smoking cessation rate at the level of subgroup analysis and at the overall population level. It is remarkable, considering that this is the kind of data pattern that has been predicted but not observed at the population level for cessation medication, such as nicotine replacement therapy and varenicline. This is the first statistically significant increase observed in population smoking cessation among US adults in nearly a quarter of a century. These findings need to be weighed carefully in regulatory policy making and in the planning of tobacco control interventions. | |||
*[https://www.bmj.com/content/bmj/358/bmj.j3262.full.pdf PDF Version] | |||
*Citation: Zhu S, Zhuang Y, Wong S, Cummins S E, Tedeschi G J. E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys BMJ 2017; 358 :j3262 doi:10.1136/bmj.j3262 | |||
*Acknowledgement: This study was supported by the National Cancer Institute of the National Institutes of Health under the State and Community Tobacco Control (SCTC) Initiative (award No U01CA154280). | |||
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===2017: [https://europa.eu/eurobarometer/surveys/detail/2146 Attitudes of Europeans towards tobacco and electronic cigarettes]=== | ===2017: [https://europa.eu/eurobarometer/surveys/detail/2146 Attitudes of Europeans towards tobacco and electronic cigarettes]=== | ||
*7.5 million EU citizens have quit smoking with nicotine vapes (“e-cigarettes”) | *7.5 million EU citizens have quit smoking with nicotine vapes (“e-cigarettes”) | ||
===2016: [https://tobaccocontrol.bmj.com/content/25/Suppl_1/i90 Long-term e-cigarette use and smoking cessation: a longitudinal study with US population ]=== | |||
*Long-term use of e-cigarettes was associated with a higher rate of quitting smoking | |||
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/25/Suppl_1/i90.full.pdf PDF Version] | |||
*Citation: Zhuang Y, Cummins SE, Y Sun J, et alLong-term e-cigarette use and smoking cessation: a longitudinal study with US populationTobacco Control 2016;25:i90-i95. | |||
*Acknowledgement: This study was supported by the National Cancer Institute of the National Institutes of Health under the State and Community Tobacco Control Initiative, Award Number U01CA154280. | |||
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===[https://docs.google.com/document/d/13-D2q1P0KpmZuoFBkKV4l9wUEQ-zcHfp6MAVJGoAaG4/edit?usp=sharing INNCO's List smoking cessation]=== | ===[https://docs.google.com/document/d/13-D2q1P0KpmZuoFBkKV4l9wUEQ-zcHfp6MAVJGoAaG4/edit?usp=sharing INNCO's List smoking cessation]=== | ||
Started: continue @ | Started: continue @ “Among smokers who have attempted to stop without professional support, those who use e-cigarettes are more likely to report continued abstinence than those who used a licensed NRT products [i.e., nicotine patches, gum or lozenges].” | ||
https:// | https://onlinelibrary.wiley.com/doi/full/10.1111/add.12623 | ||
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