Richardpruen (talk | contribs) (→Suggested additions to this page: Added immune system study) |
Richardpruen (talk | contribs) (→Suggested additions to this page: added some relevant studies) |
||
| Line 1,333: | Line 1,333: | ||
* Review of existing evidence | * Review of existing evidence | ||
* Mahmoudzadeh L, Abtahi Froushani SM, Ajami M, Mahmoudzadeh M. Adv Pharm Bull. 2023 Jan;13(1):69-78. doi: 10.34172/apb.2023.008. Epub 2022 Jan 4. PMID: 36721811 Free PMC article | * Mahmoudzadeh L, Abtahi Froushani SM, Ajami M, Mahmoudzadeh M. Adv Pharm Bull. 2023 Jan;13(1):69-78. doi: 10.34172/apb.2023.008. Epub 2022 Jan 4. PMID: 36721811 Free PMC article | ||
=== 2023: https://pubmed.ncbi.nlm.nih.gov/36708864/ === | |||
* We found that, following acute or chronic exposure, particulate matter extract from the aerosol of an HTP, the Tobacco Heating System (THS), was less harmful to the bone coculture system than reference cigarette (1R6F) smoke extract. In the fracture healing model, cultures exposed to the THS extract maintained similar osteoclast activity and calcium deposits as control cultures. Conversely, smoke extract exposure promoted osteoclast activity, resulting in an osteoporotic environment, whose formation could be prevented by bisphosphonate coadministration. Thus, THS is potentially less harmful than cigarette smoke to bone cell differentiation and bone mineralization - both being crucial aspects during the reparative phase of fracture healing. | |||
* Comment From Clive Bates: "A characteristically cautious statement. But still annoying as it gives no sense of the magnitude of "less harmful". I realise this is not a straightforward idea (see paper), but the harm reduction proposition is necessarily quantitative, even if expressed in pseudo-quantitative terms. If they want the harm reduction proposition to succeed these industries need to develop evidence-based metrics for communicating risk reduction. Eg. it required xx times the exposure to vape liquids to have the same effect as tobacco smoke." | |||
* Cell/organoid study | |||
* Note tobacco industry funded (PMI) | |||
* Weng W, Bovard D, Zanetti F, Ehnert S, Braun B, Uynuk-Ool T, Histing T, Hoeng J, Nussler AK, Aspera-Werz RH. Food Chem Toxicol. 2023 Jan 25:113637. doi: 10.1016/j.fct.2023.113637. Online ahead of print. PMID: 36708864 | |||
=== 2023: [https://pubmed.ncbi.nlm.nih.gov/36706800/ Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron.] === | |||
* Nicotine-induced antinociception was inhibited by intrathecal pre-treatment with yohimbine, an α2 adrenergic receptor antagonist. These results indicated that nicotine may suppress BCAO-induced mechanical hypersensitivity through the activation of the descending pain control system via orexin neurons. | |||
* It is possible that findings like this point to new meds applications. But more subtly, they may suggest that sub-conscious self-medication is a factor in continued nicotine use among stroke victims. | |||
* Human study | |||
* Seem like a possible therapeutic use for nicotine. Any comments? | |||
===2023 [https://www.sciencedirect.com/science/article/pii/S027869152300039X?via%3Dihub Tobacco heating system has less impact on bone metabolism than cigarette smoke]=== | ===2023 [https://www.sciencedirect.com/science/article/pii/S027869152300039X?via%3Dihub Tobacco heating system has less impact on bone metabolism than cigarette smoke]=== | ||
edits