Myth: Alternative nicotine products don't help people stop smoking: Difference between revisions

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=Studies - Not Catagorized=
=Studies - Not Catagorized=
===2019: [https://onlinelibrary.wiley.com/doi/full/10.1111/add.14851 Association of prevalence of electronic cigarette use with smoking cessation and cigarette consumption in England: a time–series analysis between 2007 and 2017]===
*The increase in prevalence of e‐cigarette use by smokers in England has been positively associated with an increase in success rates of quit attempts and overall quit rates
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14851 PDF Version]
*Citation: Beard, E., West, R., Michie, S., and Brown, J. (2020) Association of prevalence of electronic cigarette use with smoking cessation and cigarette consumption in England: a time–series analysis between 2006 and 2017. Addiction, 115: 961– 974. doi: 10.1111/add.14851.
*Acknowledgement: The STS is currently primarily funded by Cancer Research UK (C1417/A14135; C36048/A11654; C44576/A19501), and has previously also been funded by Pfizer, GlaxoSmithKline and the Department of Health.
===2019: [https://academic.oup.com/ntr/article-abstract/22/5/728/5531618 Electronic Cigarette Use and Cigarette Abstinence Over 2 Years Among U.S. Smokers in the Population Assessment of Tobacco and Health Study]===
*In this nationally representative longitudinal cohort study of US adult cigarette smokers, daily e-cigarette use, compared to no e-cigarette use, was associated with a 77% increased odds of prolonged cigarette smoking abstinence over the subsequent 2 years. Regular use of e-cigarettes may help some smokers to stop smoking combustible cigarettes.
*[https://sci-hub.se/10.1093/ntr/ntz114 PDF Version]
*Citation: Kalkhoran, S., Chang, Y., & Rigotti, N. A. (2019). Electronic Cigarette Use and Cigarette Abstinence Over Two Years among U.S. Smokers in the Population Assessment of Tobacco and Health Study. Nicotine & Tobacco Research. doi:10.1093/ntr/ntz114
*Acknowledgement: This study was supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (K23HL136854 to Dr. Kalkhoran).
*Article: [https://medicalxpress.com/news/2019-07-daily-e-cigarette-smokers-regular-cigarettes.amp?__twitter_impression=true&fbclid=IwAR31bxC-WqHdBdIjXClI6fA9qOVsnPAP90sUGDAHHHJuW0xw-VANcuFsT1A Daily e-cigarette use may help smokers quit regular cigarettes]




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*In totality, therefore, our findings favour the first explanation, that in our sample the daily vapers had been a more highly dependent group than the non-vapers, which would support the suggestion that vaping might be offering a novel route out of smoking for this group of smokers, albeit maintaining their nicotine addiction.
*In totality, therefore, our findings favour the first explanation, that in our sample the daily vapers had been a more highly dependent group than the non-vapers, which would support the suggestion that vaping might be offering a novel route out of smoking for this group of smokers, albeit maintaining their nicotine addiction.
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14722 PDF Version]
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14722 PDF Version]
*Citation: McNeill, A., Driezen, P., Hitchman, S. C., Cummings, K. M., Fong, G. T., and Borland, R. (2019) Indicators of cigarette smoking dependence and relapse in former smokers who vape compared with those who do not: findings from the 2016 International Tobacco Control Four Country Smoking and Vaping Survey. Addiction, 114( S1): 49– 60. doi: 10.1111/add.14722.
 
*This study was supported by grants from the US National Cancer Institute P01CA200512, the Canadian Institutes of Health Research (FDN - 148477), and by the National Health and Medical Research Council of Australia (APP1106451). G.T.F. was supported in part from a Senior Investigator Award from the Ontario Institute for Cancer Research.




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*4.3 million US adult nicotine vapers are ex-smokers.
*4.3 million US adult nicotine vapers are ex-smokers.
*[https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6946a4-H.pdf PDF Version]
*[https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6946a4-H.pdf PDF Version]
*Citation: Cornelius ME, Wang TW, Jamal A, Loretan CG, Neff LJ. Tobacco Product Use Among Adults — United States, 2019. MMWR Morb Mortal Wkly Rep 2020;69:1736–1742. DOI:10.15585/mmwr.mm6946a4
 




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*At a population level, e-cigarette use by smokers with chronic medical conditions is associated with more quitting activity and smoking abstinence.  
*At a population level, e-cigarette use by smokers with chronic medical conditions is associated with more quitting activity and smoking abstinence.  
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876707/pdf/nihms-1539531.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876707/pdf/nihms-1539531.pdf PDF Version]
*Citation: Kalkhoran S, Chang Y, Rigotti NA. E-cigarettes and Smoking Cessation in Smokers With Chronic Conditions. Am J Prev Med. 2019;57(6):786-791. doi:10.1016/j.amepre.2019.08.017
*Acknowledgement: This study was supported by the National Heart, Lung, and Blood Institute of the NIH (K23HL136854 to Dr. Kalkhoran).
===2018: [https://www.casaa.org/wp-content/uploads/American-Cancer-Society-Position-Statement-on-Electronic-Cigarettes.pdf American Cancer Society Position Statement on Electronic Cigarettes]===
*Based on currently available evidence, using current generation e-cigarettes is less harmful than smoking cigarettes, but the health effects of long-term use are not known.
*The ACS has always supported any smoker who is considering quitting, no matter what approach they use; there is nothing more important that they can do for their health. Some smokers, despite firm clinician advice, will not attempt to quit smoking cigarettes and will not use FDA approved cessation medications.  These individuals should be encouraged to switch to the least harmful form of tobacco product possible; switching to the exclusive use of e- cigarettes is preferable to continuing to smoke combustible products.




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*Overall, the results from this study have shown that discussions between smokers and HPs about both quitting smoking, and the possible role NVPs could play as a cessation aid, were infrequent in the four countries in 2016. This may represent a lost opportunity for encouraging quitting smoking by providing a potentially attractive option to help smokers to quit.
*Overall, the results from this study have shown that discussions between smokers and HPs about both quitting smoking, and the possible role NVPs could play as a cessation aid, were infrequent in the four countries in 2016. This may represent a lost opportunity for encouraging quitting smoking by providing a potentially attractive option to help smokers to quit.
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14527 PDF Version]
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14527 PDF Version]
*Citation: Gravely, S., Thrasher, J. F., Cummings, K. M., Ouimet, J., McNeill, A., Meng, G., Lindblom, E. N., Loewen, R., O’Connor, R. J., Thompson, M. E., Hitchman, S. C., Hammond, D., Heckman, B. W., Borland, R., Yong, H.-H., Elton-Marshall, T., Bansal-Travers, M., Gartner, C., and Fong, G. T. (2019) Discussions between health professionals and smokers about nicotine vaping products: results from the 2016 ITC Four Country Smoking and Vaping Survey. Addiction, 114( S1): 71– 85. https://doi.org/10.1111/add.14527.
 
*Acknowledgement: This study was supported by grants from the US National Cancer Institute (P01 CA200512), the Canadian Institutes of Health Research (FDN-148477) and by the National Health and Medical Research Council of Australia (APP 1106451). S.G. was funded by a 3-year Canadian Cancer Society (CCS) Career Development Award in Cancer Prevention (703858). G.T.F. was supported by a Senior Investigator Award from the Ontario Institute for Cancer Research. B.W.H. was supported by NIDA (K23 DA041616).




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*This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. Vapers advised smokers to find the right combination of device, flavors and nicotine strength, continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping.
*This study describes the advice that former-smokers who used e-cigarettes to quit smoking would offer to smokers who are considering using an e-cigarette to support an attempt to quit smoking. Vapers advised smokers to find the right combination of device, flavors and nicotine strength, continue to smoke and vape for a while if they wished, not be deterred by past failed attempts to quit smoking, and expect health to improve after they have switched to vaping. Encouraging smokers to interact with vaping peers in vape shops and in online vaping-dedicated discussion forums may help significantly more smokers switch to vaping.
*[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version]
*[https://sci-hub.do/10.1093/ntr/ntx176# PDF Version]
*Citation: Christopher Russell, PhD, Tiffany Dickson, MSc, Neil McKeganey, PhD, Advice From Former-Smoking E-Cigarette Users to Current Smokers on How to Use E-Cigarettes as Part of an Attempt to Quit Smoking, Nicotine & Tobacco Research, Volume 20, Issue 8, August 2018, Pages 977–984, doi: 10.1093/ntr/ntx176
*Acknowledgement: Funding for this study was provided by Nicoventures.




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*Daily e-cigarette initiators were more likely to have quit smoking cigarettes or reduced use compared with non-users. However, less frequent e-cigarette use was not associated with cigarette cessation/reduction. These results suggest incorporating frequency of e-cigarette use is important for developing a more thorough understanding of the association between e-cigarette use and cigarette cessation.
*Daily e-cigarette initiators were more likely to have quit smoking cigarettes or reduced use compared with non-users. However, less frequent e-cigarette use was not associated with cigarette cessation/reduction. These results suggest incorporating frequency of e-cigarette use is important for developing a more thorough understanding of the association between e-cigarette use and cigarette cessation.
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/early/2018/03/24/tobaccocontrol-2017-054108.full.pdf PDF Version]
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/early/2018/03/24/tobaccocontrol-2017-054108.full.pdf PDF Version]
*Citation: Berry KM, Reynolds LM, Collins JM, et alE-cigarette initiation and associated changes in smoking cessation and reduction: the Population Assessment of Tobacco and Health Study, 2013–2015Tobacco Control 2019;28:42-49.
*Acknowledgement: Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health and the Center for Tobacco Products under Award Number P50HL120163.




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*Compared with 2006, past-12-month quit attempts and smoking cessation increased among adults aged 25–44 in recent years. Current e-cigarette use was associated with increased past-12-month quit attempts and successful smoking cessation among established smokers. These findings are relevant to future tobacco policy decisions.
*Compared with 2006, past-12-month quit attempts and smoking cessation increased among adults aged 25–44 in recent years. Current e-cigarette use was associated with increased past-12-month quit attempts and successful smoking cessation among established smokers. These findings are relevant to future tobacco policy decisions.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751520/pdf/nty211.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751520/pdf/nty211.pdf PDF Version]
*Citation: Johnson L, Ma Y, Fisher SL, et al. E-cigarette Usage Is Associated With Increased Past-12-Month Quit Attempts and Successful Smoking Cessation in Two US Population-Based Surveys. Nicotine Tob Res. 2019;21(10):1331-1338. doi:10.1093/ntr/nty211
*Acknowledgement: Research reported in this paper was supported by National Institute on Drug Abuse (NIDA) grants R01DA036583 (LJB), R01DA042195 (RAG), R01DA038076 (LSC), R21DA033827 (RCC), and K12DA041449 (ATR); National Cancer Institute (NCI) grants U19CA203654 (LJB), P30CA091842 (LJB), and P30CA091842-16S2 (LSC); National Heart, Lung, and Blood Institute (NHLBI) grant R01HL109031 (TBB), National Institute on Alcohol Abuse and Alcoholism grant R21AA024888 (SMH), National Center For Advancing Translational Sciences grant TL1TR002344 (LJ), a grant from the Foundation for Barnes-Jewish Hospital (ATR), and by Grant 2015215 from the Doris Duke Charitable Foundation (SMH).




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*This study, based on the largest representative sample of e-cigarette users to date, provides a strong case that e-cigarette use was associated with an increase in smoking cessation at the population level. We found that e-cigarette use was associated with an increased smoking cessation rate at the level of subgroup analysis and at the overall population level. It is remarkable, considering that this is the kind of data pattern that has been predicted but not observed at the population level for cessation medication, such as nicotine replacement therapy and varenicline. This is the first statistically significant increase observed in population smoking cessation among US adults in nearly a quarter of a century. These findings need to be weighed carefully in regulatory policy making and in the planning of tobacco control interventions.
*This study, based on the largest representative sample of e-cigarette users to date, provides a strong case that e-cigarette use was associated with an increase in smoking cessation at the population level. We found that e-cigarette use was associated with an increased smoking cessation rate at the level of subgroup analysis and at the overall population level. It is remarkable, considering that this is the kind of data pattern that has been predicted but not observed at the population level for cessation medication, such as nicotine replacement therapy and varenicline. This is the first statistically significant increase observed in population smoking cessation among US adults in nearly a quarter of a century. These findings need to be weighed carefully in regulatory policy making and in the planning of tobacco control interventions.
*[https://www.bmj.com/content/bmj/358/bmj.j3262.full.pdf PDF Version]
*[https://www.bmj.com/content/bmj/358/bmj.j3262.full.pdf PDF Version]
*Citation: Zhu S, Zhuang Y, Wong S, Cummins S E, Tedeschi G J. E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys BMJ 2017; 358 :j3262 doi:10.1136/bmj.j3262
*Acknowledgement: This study was supported by the National Cancer Institute of the National Institutes of Health under the State and Community Tobacco Control (SCTC) Initiative (award No U01CA154280).




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*Consistent with randomized trials and those observational studies that measure frequency of e-cigarette use, both quit attempts and quit success were positively associated with increased frequency of e-cigarette use. Frequency of e-cigarette use was important in gauging the nature of these relationships.
*Consistent with randomized trials and those observational studies that measure frequency of e-cigarette use, both quit attempts and quit success were positively associated with increased frequency of e-cigarette use. Frequency of e-cigarette use was important in gauging the nature of these relationships.
*[https://sci-hub.st/10.1093/ntr/ntx166 PDF Version]
*[https://sci-hub.st/10.1093/ntr/ntx166 PDF Version]
*Citation: Levy, D. T., Yuan, Z., Luo, Y., & Abrams, D. B. (2017). The Relationship of E-Cigarette Use to Cigarette Quit Attempts and Cessation: Insights From a Large, Nationally Representative U.S. Survey. Nicotine & Tobacco Research, 20(8), 931–939. doi:10.1093/ntr/ntx166
*Acknowledgement: Funding was received by Drs. Levy and Abrams from the National Institute on Drug Abuse under grant R01DA036497. Dr. Levy also received funding from the National Cancer Institute under grant P01-CA200512.




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*Mean cigarettes per day decreased by 37% when e-cigarettes were available relative to baseline. Nicotine-containing cartridges were associated with greater use and craving reduction than 0 mg. Alleviation of withdrawal symptoms and taste and enjoyment factors predicted e-cigarette use.
*Mean cigarettes per day decreased by 37% when e-cigarettes were available relative to baseline. Nicotine-containing cartridges were associated with greater use and craving reduction than 0 mg. Alleviation of withdrawal symptoms and taste and enjoyment factors predicted e-cigarette use.
*[https://sci-hub.se/10.1093/ntr/ntx269 PDF Versioin]
*[https://sci-hub.se/10.1093/ntr/ntx269 PDF Versioin]
*Citation: Tucker, M. R., Laugesen, M., Bullen, C., & Grace, R. C. (2017). Predicting Short-Term Uptake of Electronic Cigarettes: Effects of Nicotine, Subjective Effects, and Simulated Demand. Nicotine & Tobacco Research. doi:10.1093/ntr/ntx269
*Acknowledge: This research was funded by the Tobacco Control Research Tūranga: A programme of innovative research to halve the smoking prevalence in Aotearoa/New Zealand within a decade. The Tūranga is supported through funding from the Reducing Tobacco-related Harm Research Partnership, co-funded by the Health Research Council of New Zealand and the Ministry of Health of New Zealand (HRC grant: 11/818).
   
   


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*Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence).
*Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence).
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520273/pdf/tobaccocontrol-2015-052822.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520273/pdf/tobaccocontrol-2015-052822.pdf PDF Version]
*Citation: Manzoli L, Flacco ME, Ferrante M, et al. Cohort study of electronic cigarette use: effectiveness and safety at 24 months. Tob Control. 2017;26(3):284-292. doi:10.1136/tobaccocontrol-2015-052822
*Acknowledgement: The first 2 years of the study were unfunded. The next 3 years of follow-up are going to be funded through crowdfunding (Kickstarter project titled ‘E-cigarette long-term efficacy & safety: a study to complete’).




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*Among current e-cigarette users, 84% reported using e-cigarettes to quit cigarettes, to cut down on cigarettes, or because they believe they are less harmful than cigarettes. The least common reason for use was cost (48%). Among former e-cigarette users, 78% reported using e-cigarettes to quit cigarettes, to cut down on cigarettes, or because they believe they are less harmful than cigarettes, and the least common reason was also cost (30%).
*Among current e-cigarette users, 84% reported using e-cigarettes to quit cigarettes, to cut down on cigarettes, or because they believe they are less harmful than cigarettes. The least common reason for use was cost (48%). Among former e-cigarette users, 78% reported using e-cigarettes to quit cigarettes, to cut down on cigarettes, or because they believe they are less harmful than cigarettes, and the least common reason was also cost (30%).
*[https://link.springer.com/content/pdf/10.1007/s11606-017-4123-x.pdf PDF Version]
*[https://link.springer.com/content/pdf/10.1007/s11606-017-4123-x.pdf PDF Version]
*Citation: Kalkhoran, S., Alvarado, N., Vijayaraghavan, M. et al. Patterns of and reasons for electronic cigarette use in primary care patients. J GEN INTERN MED 32, 1122–1129 (2017). doi:10.1007/s11606-017-4123-x
*Acknowledgement: This work was supported by NIH National Institute on Drug Abuse R01DA034253.




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*Long-term use of e-cigarettes was associated with a higher rate of quitting smoking
*Long-term use of e-cigarettes was associated with a higher rate of quitting smoking
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/25/Suppl_1/i90.full.pdf PDF Version]
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/25/Suppl_1/i90.full.pdf PDF Version]
*Citation: Zhuang Y, Cummins SE, Y Sun J, et alLong-term e-cigarette use and smoking cessation: a longitudinal study with US populationTobacco Control 2016;25:i90-i95.
 
*Acknowledgement: This study was supported by the National Cancer Institute of the National Institutes of Health under the State and Community Tobacco Control Initiative, Award Number U01CA154280.




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*Changes in prevalence of e-cigarette use in England have been positively associated with the success rates of quit attempts. No clear association has been found between e-cigarette use and the rate of quit attempts or the use of other quitting aids, except for NRT obtained on prescription, where the association has been negative.
*Changes in prevalence of e-cigarette use in England have been positively associated with the success rates of quit attempts. No clear association has been found between e-cigarette use and the rate of quit attempts or the use of other quitting aids, except for NRT obtained on prescription, where the association has been negative.
*[https://www.bmj.com/content/bmj/354/bmj.i4645.full.pdf PDF Version]
*[https://www.bmj.com/content/bmj/354/bmj.i4645.full.pdf PDF Version]
*Citation: Beard E, West R, Michie S, Brown J. Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends BMJ 2016; 354 :i4645 doi:10.1136/bmj.i4645
*Acknowledgement:  The Smoking Toolkit Study is currently primarily funded by Cancer Research UK (C1417/A14135; C36048/A11654; C44576/A19501), and has previously also been funded by Pfizer, GlaxoSmithKline, and the Department of Health.


===2016: [https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/534708/E-cigarettes_joint_consensus_statement_2016.pdf E-cigarettes: a developing public health consensus]===
*From: Public Health England, Action on Smoking and Health, Association of Directors of Public Health, British Lung Foundation, Cancer Research UK, Faculty of Public Health, Fresh North East, Healthier Futures, Public Health Action, Royal College of Physicians, Royal Society for Public Health, UK Centre for Tobacco and Alcohol Studies, UK Health Forum
*We all agree that e-cigarettes are significantly less harmful than smoking. One in two lifelong smokers dies from their addiction. All the evidence suggests that the health risks posed by e-cigarettes are relatively small by comparison but we must continue to study the long-term effects.
*And yet, millions of smokers have the impression that e-cigarettes are at least as harmful as tobacco
*The public health opportunity is in helping smokers to quit, so we may encourage smokers to try vaping but we certainly encourage vapers to stop smoking tobacco completely.
*We know that e-cigarettes are the most popular quitting tool in the country with more than 10 times as many people using them than using local stop smoking services.
*The current national evidence is that in the UK regular e-cigarette among youth use is almost exclusively confined to those young people who have already smoked, and youth smoking prevalence is continuing to fall.
*We should not forget what is important here. We know that smoking is the number one killer in England and we have a public health responsibility to provide smokers with the information and the tools to help them quit smoking completely and forever.




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*Conclusion: Extremely low e-cigarette use among never-smokers and longer term former smokers suggest that e-cigarettes neither promote widespread initiation nor relapse among adults. Recognition of the heterogeneity of smokers, including the time since quitting, is critical to draw accurate conclusions about patterns of e-cigarette use at the population level and its potential for public health benefit or harm.
*Conclusion: Extremely low e-cigarette use among never-smokers and longer term former smokers suggest that e-cigarettes neither promote widespread initiation nor relapse among adults. Recognition of the heterogeneity of smokers, including the time since quitting, is critical to draw accurate conclusions about patterns of e-cigarette use at the population level and its potential for public health benefit or harm.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896829/pdf/ntv237.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896829/pdf/ntv237.pdf PDF Version]
*Citation: Delnevo CD, Giovenco DP, Steinberg MB, et al. Patterns of Electronic Cigarette Use Among Adults in the United States. Nicotine Tob Res. 2016;18(5):715-719. doi:10.1093/ntr/ntv237
 
*Acknowledgement: This research was supported in part by funding from the National Institutes of Health (R01CA19044 [CDD and MBS] and K01DA037950 [JLP])
   
   


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*E‐cigarette use in the European Union appears to be largely confined to current or former smokers, while current use and nicotine use by people who have never smoked is rare. More than one‐third of current e‐cigarette users polled reported smoking cessation and reduction.
*E‐cigarette use in the European Union appears to be largely confined to current or former smokers, while current use and nicotine use by people who have never smoked is rare. More than one‐third of current e‐cigarette users polled reported smoking cessation and reduction.
*[https://sci-hub.st/10.1111/add.13506 PDF Version]
*[https://sci-hub.st/10.1111/add.13506 PDF Version]
*Citation: Farsalinos, K. E., Poulas, K., Voudris, V., & Le Houezec, J. (2016). Electronic cigarette use in the European Union: analysis of a representative sample of 27 460 Europeans from 28 countries. Addiction, 111(11), 2032–2040. doi:10.1111/add.13506
 
*Acknowledgement: No funding was provided for this study




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*“Snus has both contributed to decreasing initiation of smoking and ...appears to facilitate smoking cessation. ...Snus has been a major factor behind Sweden’s record-low prevalence of smoking and lowest tobacco-related mortality among men in Europe.”
*“Snus has both contributed to decreasing initiation of smoking and ...appears to facilitate smoking cessation. ...Snus has been a major factor behind Sweden’s record-low prevalence of smoking and lowest tobacco-related mortality among men in Europe.”
*[https://www.mdpi.com/1660-4601/13/11/1110/pdf PDF Version]
*[https://www.mdpi.com/1660-4601/13/11/1110/pdf PDF Version]
*Citation: Ramström, L.; Borland, R.; Wikmans, T. Patterns of Smoking and Snus Use in Sweden: Implications for Public Health. Int. J. Environ. Res. Public Health 2016, 13, 1110. https://doi.org/10.3390/ijerph13111110
 




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*“This systematic review and meta-analyses assessed the findings of six studies which reported smoking cessation after using e-cigarettes. We found an association between nicotine-enriched e-cigarette use and smoking cessation, suggesting that the devices may be an effective alternative smoking cessation method. We also found that use of e-cigarettes was also associated with a reduction in the number of cigarettes used, suggesting they may also have a role in tobacco harm reduction programs. To our knowledge, this is the most comprehensive evidence to date on this issue, and while there are a number of important implications for further research, these findings provide timely information to inform regulatory strategies.”
*“This systematic review and meta-analyses assessed the findings of six studies which reported smoking cessation after using e-cigarettes. We found an association between nicotine-enriched e-cigarette use and smoking cessation, suggesting that the devices may be an effective alternative smoking cessation method. We also found that use of e-cigarettes was also associated with a reduction in the number of cigarettes used, suggesting they may also have a role in tobacco harm reduction programs. To our knowledge, this is the most comprehensive evidence to date on this issue, and while there are a number of important implications for further research, these findings provide timely information to inform regulatory strategies.”
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378973/pdf/pone.0122544.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378973/pdf/pone.0122544.pdf PDF Version]
*Citation: Rahman MA, Hann N, Wilson A, Mnatzaganian G, Worrall-Carter L. E-cigarettes and smoking cessation: evidence from a systematic review and meta-analysis. PLoS One. 2015;10(3):e0122544. Published 2015 Mar 30. doi:10.1371/journal.pone.0122544
 
*Acknowledgement: The authors have no support or funding to report.
   
   


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*Results: At follow-up, 23% were intensive users, 29% intermittent users, 18% had used once or twice, and 30% had not tried e-cigarettes. Logistic regression controlling for demographics and tobacco dependence indicated that intensive users of e-cigarettes were 6 times more likely than non-users/triers to report that they quit smoking. Daily use of electronic cigarettes for at least 1 month is strongly associated with quitting smoking at follow-up. Further investigation of the underlying reasons for intensive versus intermittent use will help shed light on the mechanisms underlying the associations between e-cigarette use, motivation to quit, and smoking cessation.
*Results: At follow-up, 23% were intensive users, 29% intermittent users, 18% had used once or twice, and 30% had not tried e-cigarettes. Logistic regression controlling for demographics and tobacco dependence indicated that intensive users of e-cigarettes were 6 times more likely than non-users/triers to report that they quit smoking. Daily use of electronic cigarettes for at least 1 month is strongly associated with quitting smoking at follow-up. Further investigation of the underlying reasons for intensive versus intermittent use will help shed light on the mechanisms underlying the associations between e-cigarette use, motivation to quit, and smoking cessation.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375383/pdf/ntu200.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375383/pdf/ntu200.pdf PDF Version]
*Citation: Biener L, Hargraves JL. A longitudinal study of electronic cigarette use among a population-based sample of adult smokers: association with smoking cessation and motivation to quit. Nicotine Tob Res. 2015;17(2):127-133. doi:10.1093/ntr/ntu200
 
*Acknowledgement: This work was supported by a grant from the US National Cancer Institute, grant #R01CA151384-03.




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*Whether e-cigarette use is associated with quitting depends on type and frequency of use. Compared with respondents not using e-cigarettes, daily tank users were more likely, and non-daily cigalike users were less likely, to have quit. Tanks were more likely to be used by older respondents and respondents with lower education.
*Whether e-cigarette use is associated with quitting depends on type and frequency of use. Compared with respondents not using e-cigarettes, daily tank users were more likely, and non-daily cigalike users were less likely, to have quit. Tanks were more likely to be used by older respondents and respondents with lower education.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580313/pdf/ntv078.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580313/pdf/ntv078.pdf PDF Version]
*Citation: Hitchman SC, Brose LS, Brown J, Robson D, McNeill A. Associations Between E-Cigarette Type, Frequency of Use, and Quitting Smoking: Findings From a Longitudinal Online Panel Survey in Great Britain. Nicotine Tob Res. 2015;17(10):1187-1194. doi:10.1093/ntr/ntv078
 
*Acknowledgement: All authors are members of the UK Centre for Tobacco & Alcohol Studies, a UK Clinical Research Collaboration Public Health Research: Centre of Excellence whose work is supported by funding from the Medical Research Council, British Heart Foundation, Cancer Research UK, Economic and Social Research Council, and the National Institute for Health Research under the auspices of the UK Clinical Research Collaboration is gratefully acknowledged (MR/K023195/1). JB’s post is funded by a fellowship from the UK Society for the Study of Addiction.
   
   


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*Follow-up data were available for 236 e-smokers, 491 tobacco smokers, and 232 dual smokers (overall response rate 70.8%). All e-smokers were tobacco ex-smokers. At 12 months, 61.9% of the e-smokers were still abstinent from tobacco smoking; 20.6% of the tobacco smokers and 22.0% of the dual smokers achieved tobacco abstinence. Adjusting for potential confounders, tobacco smoking abstinence or cessation remained significantly more likely among e-smokers...
*Follow-up data were available for 236 e-smokers, 491 tobacco smokers, and 232 dual smokers (overall response rate 70.8%). All e-smokers were tobacco ex-smokers. At 12 months, 61.9% of the e-smokers were still abstinent from tobacco smoking; 20.6% of the tobacco smokers and 22.0% of the dual smokers achieved tobacco abstinence. Adjusting for potential confounders, tobacco smoking abstinence or cessation remained significantly more likely among e-smokers...
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464650/pdf/pone.0129443.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464650/pdf/pone.0129443.pdf PDF Version]
*Citation: Manzoli L, Flacco ME, Fiore M, et al. Electronic Cigarettes Efficacy and Safety at 12 Months: Cohort Study. PLoS One. 2015;10(6):e0129443. Published 2015 Jun 10. doi:10.1371/journal.pone.0129443
*Acknowledgement: The authors have no support or funding to report.




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*Conclusion: “Among smokers who have attempted to stop without professional support, those who use e-cigarettes are more likely to report continued abstinence than those who used a licensed NRT product bought over-the-counter or no aid to cessation. This difference persists after adjusting for a range of smoker characteristics such as nicotine dependence.”
*Conclusion: “Among smokers who have attempted to stop without professional support, those who use e-cigarettes are more likely to report continued abstinence than those who used a licensed NRT product bought over-the-counter or no aid to cessation. This difference persists after adjusting for a range of smoker characteristics such as nicotine dependence.”
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171752/pdf/add0109-1531.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171752/pdf/add0109-1531.pdf PDF Version]
*Citation: Brown J, Beard E, Kotz D, Michie S, West R. Real-world effectiveness of e-cigarettes when used to aid smoking cessation: a cross-sectional population study. Addiction. 2014;109(9):1531-1540. doi:10.1111/add.12623
*Acknowledgement: The research team is part of the UK Centre for Tobacco and Alcohol Studies. JB's post is funded by a fellowship from the UK Society for the Study of Addiction; R.W. is funded by Cancer Research UK; Cancer Research UK, the Department of Health and Pfizer funded data collection for this study (including a Pfizer investigator initiated award), and that at the outset data collection for the Smoking Toolkit Study was also supported by GlaxoSmithKline and Johnson and Johnson.


===2014: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238186/ E-cigarette versus nicotine inhaler: comparing the perceptions and experiences of inhaled nicotine devices]=== 
*Related Article: [https://www.cinj.org/patient-care/e-cigarettes-vs-nicotine-inhalers E-Cigarettes vs. Nicotine Inhalers]
*“In conclusion, during this brief trial, the e-cigarette was found to be more acceptable, provided more satisfaction and rewards, and had higher perceived benefit than the nicotine inhaler. These findings may explain why the e-cigarette has become popular among smokers while the inhaler has not achieved the same favorability. Based on this difference, e-cigarettes could have the potential to become “tobacco cigarette substitutes,” owing to their high acceptance and perceived effectiveness. While toxicants have been identified in e-cigarettes, they are present at orders of magnitude lower than tobacco cigarettes. As such, e-cigarettes may hold value as a harm reduction strategy among those unwilling or unable to quit. However, given the large variation in the market with respect to brands, more data are needed to demonstrate their efficacy and safety, and to allow physicians to more appropriately inform their patients about these products.”
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238186/pdf/11606_2014_Article_2889.pdf PDF Version]
*Citation: Steinberg MB, Zimmermann MH, Delnevo CD, et al. E-cigarette versus nicotine inhaler: comparing the perceptions and experiences of inhaled nicotine devices. J Gen Intern Med. 2014;29(11):1444-1450. doi:10.1007/s11606-014-2889-7
*Acknowledgement: This study was funded through a pilot grant from the Rutgers–Cancer Institute of New Jersey (P30CA072720).




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*E-cigarette is an attractive long-term alternative and safer source of nicotine to conventional cigarette. Since their invention in 2003, there has been constant innovation and development of more efficient and appealing products. Here we show for the first time that second generation PVs can substantially decrease cigarette consumption without causing significant side effects in smokers not intending to quit. Moreover, overall participants’ perception and acceptance of these products was very good, in particular for those who quit or reduced smoking. Compared to our earlier work with first generation “cig-alikes”, technical problems and difficulties in use familiarization with second generation PVs were negligible. Improved products reliability and attractiveness might have contributed to the very low number of study failures and lost to follow-up and high success rates thus confirming the notion that these products are attractive substitutes for conventional cigarettes. Although large and carefully conducted RCTs will be required to confirm these preliminary encouraging observations, the notion that second generation PVs can substantially decrease cigarette consumption in smokers not intending to quit should be taken into consideration by regulatory authorities seeking to adopt proportional measures for the vapour category
*E-cigarette is an attractive long-term alternative and safer source of nicotine to conventional cigarette. Since their invention in 2003, there has been constant innovation and development of more efficient and appealing products. Here we show for the first time that second generation PVs can substantially decrease cigarette consumption without causing significant side effects in smokers not intending to quit. Moreover, overall participants’ perception and acceptance of these products was very good, in particular for those who quit or reduced smoking. Compared to our earlier work with first generation “cig-alikes”, technical problems and difficulties in use familiarization with second generation PVs were negligible. Improved products reliability and attractiveness might have contributed to the very low number of study failures and lost to follow-up and high success rates thus confirming the notion that these products are attractive substitutes for conventional cigarettes. Although large and carefully conducted RCTs will be required to confirm these preliminary encouraging observations, the notion that second generation PVs can substantially decrease cigarette consumption in smokers not intending to quit should be taken into consideration by regulatory authorities seeking to adopt proportional measures for the vapour category
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245610/pdf/ijerph-11-11220.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245610/pdf/ijerph-11-11220.pdf PDF Version]
*Citation: Adriaens K, Van Gucht D, Declerck P, Baeyens F. Effectiveness of the electronic cigarette: An eight-week Flemish study with six-month follow-up on smoking reduction, craving and experienced benefits and complaints. Int J Environ Res Public Health. 2014;11(11):11220-11248. Published 2014 Oct 29. doi:10.3390/ijerph111111220
*Acknowledgement: No external funding for this study was obtained.




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*Complete tobacco cessation is the best outcome for smokers, but the powerful addictive qualities of nicotine and of the ritualistic behavior of smoking create a huge hurdle, even for those with a strong desire to quit. Tobacco harm reduction (THR), the substitution of low-risk nicotine products for cigarette smoking, is a realistic strategy for smokers who have difficulty quitting. E-cigarettes are the newest and most promising products for THR. This approach has been recently exploited to reduce or reverse the burden of harm in smokers with mental health disorders and chronic airway disease.
*Complete tobacco cessation is the best outcome for smokers, but the powerful addictive qualities of nicotine and of the ritualistic behavior of smoking create a huge hurdle, even for those with a strong desire to quit. Tobacco harm reduction (THR), the substitution of low-risk nicotine products for cigarette smoking, is a realistic strategy for smokers who have difficulty quitting. E-cigarettes are the newest and most promising products for THR. This approach has been recently exploited to reduce or reverse the burden of harm in smokers with mental health disorders and chronic airway disease.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247211/pdf/12889_2014_Article_7263.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247211/pdf/12889_2014_Article_7263.pdf PDF Version]
*Citation: Polosa R, Caponnetto P, Maglia M, Morjaria JB, Russo C. Success rates with nicotine personal vaporizers: a prospective 6-month pilot study of smokers not intending to quit. BMC Public Health. 2014;14:1159. Published 2014 Nov 8. doi:10.1186/1471-2458-14-1159
 
*Acknowledgement: The authors wish to thank FlavourArt. Authors wish to thank LIAF, Lega Italiana Anti Fumo (Italian acronym for Italian Anti Smoking League) for supporting this research.




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*In conclusion, in this large sample of dedicated EC users, it seems that ECs are used as long-term substitutes to smoking. They can be effective even in subjects who are highly dependent on smoking and are heavy smokers. Mild temporary side-effects and significant benefits are reported by this population. Motivation for using ECs comes from their expected less harmful potential compared to smoking.
*In conclusion, in this large sample of dedicated EC users, it seems that ECs are used as long-term substitutes to smoking. They can be effective even in subjects who are highly dependent on smoking and are heavy smokers. Mild temporary side-effects and significant benefits are reported by this population. Motivation for using ECs comes from their expected less harmful potential compared to smoking.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025024/pdf/ijerph-11-04356.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025024/pdf/ijerph-11-04356.pdf PDF Version]
*Citation: Farsalinos KE, Romagna G, Tsiapras D, Kyrzopoulos S, Voudris V. Characteristics, perceived side effects and benefits of electronic cigarette use: a worldwide survey of more than 19,000 consumers. Int J Environ Res Public Health. 2014;11(4):4356-4373. Published 2014 Apr 22. doi:10.3390/ijerph110404356
 
*Acknowledgement: The study was funded by a funding campaign of E-Cigarette Research Advocates Group, the owners of the website www.ecigarette-research.com. This is a non-profit group of electronic cigarette users with no relation to the electronic cigarette or other industry.




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*Thus, this may be the first study to suggest that smokers who want to quit smoking for immediate, extrinsic rewards may be attracted to use e-cigarettes to stop smoking cigarettes than smokers who want to quit smoking for intrinsic reasons such as health concerns. In conclusion, e-cigarettes appear to provide a “smoking” alternative to a section of cigarette smokers who may not quit smoking for health reasons. Public health efforts may need to consider employing e-cigarettes to promote tobacco-related harm reduction.
*Thus, this may be the first study to suggest that smokers who want to quit smoking for immediate, extrinsic rewards may be attracted to use e-cigarettes to stop smoking cigarettes than smokers who want to quit smoking for intrinsic reasons such as health concerns. In conclusion, e-cigarettes appear to provide a “smoking” alternative to a section of cigarette smokers who may not quit smoking for health reasons. Public health efforts may need to consider employing e-cigarettes to promote tobacco-related harm reduction.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511704/pdf/nihms676311.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511704/pdf/nihms676311.pdf PDF Version]
*Citation: Pokhrel P, Herzog TA. Reasons for quitting cigarette smoking and electronic cigarette use for cessation help. Psychol Addict Behav. 2015;29(1):114-121. doi:10.1037/adb0000025
 
   
   


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*This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical.
*This study highlights higher interest in ENDS versus smokeless tobacco and greater interest in both for harm reduction and cessation than due to novelty or smoking restrictions. Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical.
*[https://sci-hub.st/10.1093/ntr/ntu103 PDF Version]
*[https://sci-hub.st/10.1093/ntr/ntu103 PDF Version]
*Citation: Berg, C. J., Haardoerfer, R., Escoffery, C., Zheng, P., & Kegler, M. (2014). Cigarette Users’ Interest in Using or Switching to Electronic Nicotine Delivery Systems for Smokeless Tobacco for Harm Reduction, Cessation, or Novelty: A Cross-Sectional Survey of US Adults. Nicotine & Tobacco Research, 17(2), 245–255. doi:10.1093/ntr/ntu103
 
*Acknowledgement: This work was supported by the Centers for Disease Control and Prevention (3 U48 DP001909-04S1 to Principal Investigator (PI): CJB), the National Cancer Institute (U01CA154282-01 to PI: MK; 1K07CA139114-01A1 to PI: CJB), and the Georgia Cancer Coalition (PI: CJB).




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*At 6 months, verified abstinence was 7·3% (21 of 289) with nicotine e-cigarettes, 5·8% (17 of 295) with patches, and 4·1% (three of 73) with placebo e-cigarettes  
*At 6 months, verified abstinence was 7·3% (21 of 289) with nicotine e-cigarettes, 5·8% (17 of 295) with patches, and 4·1% (three of 73) with placebo e-cigarettes  
*[https://sci-hub.st/10.1016/S0140-6736(13)61842-5 PDF Version]
*[https://sci-hub.st/10.1016/S0140-6736(13)61842-5 PDF Version]
*Citation: Bullen C, Howe C, Laugesen M, McRobbie H, Parag V, Williman J, Walker N. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013 Nov 16;382(9905):1629-37. doi: 10.1016/S0140-6736(13)61842-5. Epub 2013 Sep 9. PMID: 24029165.
 
*Acknowledgement: Funding: Health Research Council of New Zealand.




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*Nicotine’s beneficial effects can be controlled, and the detrimental effects of the smoky delivery system can be attenuated, by providing the drug via less hazardous delivery systems. Although more research is needed, e-cigs appear to be effective cigarette substitutes for inveterate smokers, and the health improvements enjoyed by switchers do not differ from those enjoyed by tobacco/nicotine abstainers.
*Nicotine’s beneficial effects can be controlled, and the detrimental effects of the smoky delivery system can be attenuated, by providing the drug via less hazardous delivery systems. Although more research is needed, e-cigs appear to be effective cigarette substitutes for inveterate smokers, and the health improvements enjoyed by switchers do not differ from those enjoyed by tobacco/nicotine abstainers.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850892/pdf/1477-7517-10-19.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850892/pdf/1477-7517-10-19.pdf PDF Version]
*Citation: Polosa R, Rodu B, Caponnetto P, Maglia M, Raciti C. A fresh look at tobacco harm reduction: the case for the electronic cigarette. Harm Reduct J. 2013;10:19. Published 2013 Oct 4. doi:10.1186/1477-7517-10-19
 




===2013: [https://www.frontiersin.org/articles/10.3389/fpubh.2013.00056/full Electronic cigarettes and vaping: a new challenge in clinical medicine and public health. A literature review]===  
===2013: [https://www.frontiersin.org/articles/10.3389/fpubh.2013.00056/full Electronic cigarettes and vaping: a new challenge in clinical medicine and public health. A literature review]===  
*When compared to the harmful effects of smoking, these studies suggest that vaping could be used as a possible “harm reduction” tool. There is evidence supporting e-cigarettes as an aide for smoking cessation, at least as successful as currently available FDA-approved NRTs.
*When compared to the harmful effects of smoking, these studies suggest that vaping could be used as a possible “harm reduction” tool. There is evidence supporting e-cigarettes as an aide for smoking cessation, at least as successful as currently available FDA-approved NRTs.
*Citation: Palazzolo, D. L. (2013). Electronic Cigarettes and Vaping: A New Challenge in Clinical Medicine and Public Health. A Literature Review. Frontiers in Public Health, 1. doi:10.3389/fpubh.2013.00056
 




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*While we found evidence supporting the view that e-cigarette use may be a bridge to quitting, we found very little evidence of e-cigarette use among adults who had never smoked. British smokers would benefit from information about the effective use, risks, and benefits of e-cigarettes, as this might enable the use of e-cigarettes to improve public health.
*While we found evidence supporting the view that e-cigarette use may be a bridge to quitting, we found very little evidence of e-cigarette use among adults who had never smoked. British smokers would benefit from information about the effective use, risks, and benefits of e-cigarettes, as this might enable the use of e-cigarettes to improve public health.
*[https://scholar.google.com/scholar_url?url=https://academic.oup.com/ntr/article-pdf/15/10/1737/4005852/ntt057.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=5-niYKGiHo6RywT0wZbgCg&scisig=AAGBfm1x30ekBGwfhPgkxdJKFW0eOfPFPw PDF Version]
*[https://scholar.google.com/scholar_url?url=https://academic.oup.com/ntr/article-pdf/15/10/1737/4005852/ntt057.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=5-niYKGiHo6RywT0wZbgCg&scisig=AAGBfm1x30ekBGwfhPgkxdJKFW0eOfPFPw PDF Version]
*Citation: Martin Dockrell, BA, Rory Morrison, BSc, Linda Bauld, PhD, Ann McNeill, PhD, E-Cigarettes: Prevalence and Attitudes in Great Britain, Nicotine & Tobacco Research, Volume 15, Issue 10, October 2013, Pages 1737–1744, doi: 10.1093/ntr/ntt057
 
*Acknowledgements: Fieldwork was supported by Action on Smoking and Health and members of the Smokefree Action Coalition. Linda Bauld and Ann McNeill are members of the UK Centre for Tobacco Control Studies. Funding from the British Heart Foundation, Cancer Research UK, Economic and Social Research Council (ESRC), the Medical Research Council (MRC), and the National Institute for Health Research (NIHR), under the auspices of the UK Clinical Research Collaboration, is gratefully acknowledged.




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*In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects. In view of the fact that subjects in this study had no immediate intention of quitting, the reported overall abstinence rate of 8.7% at 52-week was remarkable.
*In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects. In view of the fact that subjects in this study had no immediate intention of quitting, the reported overall abstinence rate of 8.7% at 52-week was remarkable.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691171/pdf/pone.0066317.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691171/pdf/pone.0066317.pdf PDF Version]
*Citation:Caponnetto P, Campagna D, Cibella F, et al. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study [published correction appears in PLoS One. 2014;9(1). doi:10.1371/annotation/e12c22d3-a42b-455d-9100-6c7ee45d58d0]. PLoS One. 2013;8(6):e66317. Published 2013 Jun 24. doi:10.1371/journal.pone.0066317
 
*Acknowledgement: This research was supported by a grant-in-aid from Lega Italiana AntiFumo.




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*E-cigarettes are used primarily for smoking cessation, but for a longer duration than nicotine replacement therapy, and users believe them to be safer than smoking
*E-cigarettes are used primarily for smoking cessation, but for a longer duration than nicotine replacement therapy, and users believe them to be safer than smoking
*[https://sci-hub.st/10.1111/add.12150 PDF Version]
*[https://sci-hub.st/10.1111/add.12150 PDF Version]
*Citation: Dawkins, L., Turner, J., Roberts, A., & Soar, K. (2013). “Vaping” profiles and preferences: an online survey of electronic cigarette users. Addiction, 108(6), 1115–1125. doi:10.1111/add.12150
 
*No funding was received for this study. The first author has a collaborative relationship with the Electronic Cigarette Company (TECC) and Totally Wicked E-Liquids (TWEL), and has received funds from these companies to attend academic conferences. TECC and TWEL reviewed and approved the content of the questionnaire and set up links from their websites to the host site at UEL.




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*The first study to demonstrate that the nicotine e-cigarette can improve working memory.
*The first study to demonstrate that the nicotine e-cigarette can improve working memory.
*[https://sci-hub.se/10.1016/j.addbeh.2012.03.004 PDF Version]
*[https://sci-hub.se/10.1016/j.addbeh.2012.03.004 PDF Version]
*Citation: Dawkins, L., Turner, J., Hasna, S., & Soar, K. (2012). The electronic-cigarette: Effects on desire to smoke, withdrawal symptoms and cognition. Addictive Behaviors, 37(8), 970–973. doi:10.1016/j.addbeh.2012.03.004
*Acknowledgement: Electronic Cigarette Company (TECC) supplied the e-cigarettes and cartridges for this study. TECC had no involvement in the design or conduct of the study.




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*The most important message from this case series is that these smokers, with a documented history of recurring relapses, were able to quit smoking and to remain abstinent for at least six months after taking up an electronic cigarette.
*The most important message from this case series is that these smokers, with a documented history of recurring relapses, were able to quit smoking and to remain abstinent for at least six months after taking up an electronic cigarette.
*[https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/1752-1947-5-585.pdf PDF Version]
*[https://jmedicalcasereports.biomedcentral.com/track/pdf/10.1186/1752-1947-5-585.pdf PDF Version]
*Citation: Caponnetto, P., Polosa, R., Russo, C. et al. Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case series. J Med Case Reports 5, 585 (2011). https://doi.org/10.1186/1752-1947-5-585
 




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*The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit  
*The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit  
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203079/pdf/1471-2458-11-786.pdf PDF Version]
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203079/pdf/1471-2458-11-786.pdf PDF Version]
*Citation: Polosa R, Caponnetto P, Morjaria JB, Papale G, Campagna D, Russo C. Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study. BMC Public Health. 2011 Oct 11;11:786. doi: 10.1186/1471-2458-11-786. PMID: 21989407; PMCID: PMC3203079.
 
*Acknowledgement: We wish to thank Arbi Group Srl (Milano, Italy) for the free supplies of ‘Categoria’ e-Cigarette kits and nicotine cartridges. None of the authors have any competing interests to declare, but RP has received lecture fees from Pfizer and, from Feb 2011, he has been serving as a consultant for Arbi Group Srl.Arbi Group Srl (Milano, Italy), the manufacturer of the e-Cigarette supplied the product, and unrestricted technical and customer support. They were not involved in the study design, running of the study or analysis and presentation of the data.




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*Users of nicotine‐containing e‐cigarettes reported better relief of withdrawal and a greater effect on smoking cessation than those using non‐nicotine e‐cigarettes.
*Users of nicotine‐containing e‐cigarettes reported better relief of withdrawal and a greater effect on smoking cessation than those using non‐nicotine e‐cigarettes.
*[https://sci-hub.se/10.1111/j.1360-0443.2011.03505.x PDF Version]
*[https://sci-hub.se/10.1111/j.1360-0443.2011.03505.x PDF Version]
*Citation: Etter, J.-F., & Bullen, C. (2011). Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy. Addiction, 106(11), 2017–2028. doi:10.1111/j.1360-0443.2011.03505.x
===2011: [https://onlinelibrary.wiley.com/doi/full/10.1111/j.1742-1241.2011.02751.x Electronic cigarettes (e‐cigs): views of aficionados and clinical/public health Perspectives]===
*The health risks from smoking are large and are known with certainty. Comparatively, the health risks from e‐cig use are likely much smaller (if any) and temporarily switching to e‐cigs will likely yield a large health benefit.
*If the patient perceives that the e‐cig is helping them to stay off cigarettes and is not reporting any health problems likely attributable to the e‐cig, then the focus should be on staying smoke‐free rather than e‐cig free.
*[https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-1241.2011.02751.x PDF Version]
*Citation: Foulds, J., Veldheer, S., & Berg, A. (2011). Electronic cigarettes (e-cigs): views of aficionados and clinical/public health perspectives. International Journal of Clinical Practice, 65(10), 1037–1042. doi:10.1111/j.1742-1241.2011.02751.x 


===2011: [https://www.sciencedirect.com/science/article/abs/pii/S0749379710007920 Electronic Cigarettes As a Smoking-Cessation Tool: Results from an Online Survey]===
===2011: [https://www.sciencedirect.com/science/article/abs/pii/S0749379710007920 Electronic Cigarettes As a Smoking-Cessation Tool: Results from an Online Survey]===
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*The distinct and unique advantage of e-cigarettes is that they allow individuals to utilize one device that can simultaneously address nicotine withdrawal, psychological factors, and behavioral cues that serve as barriers to smoking abstinence.  
*The distinct and unique advantage of e-cigarettes is that they allow individuals to utilize one device that can simultaneously address nicotine withdrawal, psychological factors, and behavioral cues that serve as barriers to smoking abstinence.  
*[https://sci-hub.se/10.1016/j.amepre.2010.12.006 PDF Version]
*[https://sci-hub.se/10.1016/j.amepre.2010.12.006 PDF Version]
*Citation: Siegel, M. B., Tanwar, K. L., & Wood, K. S. (2011). Electronic Cigarettes As a Smoking-Cessation Tool. American Journal of Preventive Medicine, 40(4), 472–475. doi:10.1016/j.amepre.2010.12.006




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*There were pervasive themes including the language and culture of vaping; social and informational support among vapers, motives and perceived benefits of using e-cigs versus cigarettes including cigarette-like enjoyment, cost, restored sense of taste and smell, and improved breathing and exercise tolerance; rapidly reduced nicotine tolerance and dependence; and a strong interest in e-cig–related research and policy.
*There were pervasive themes including the language and culture of vaping; social and informational support among vapers, motives and perceived benefits of using e-cigs versus cigarettes including cigarette-like enjoyment, cost, restored sense of taste and smell, and improved breathing and exercise tolerance; rapidly reduced nicotine tolerance and dependence; and a strong interest in e-cig–related research and policy.
*[https://sci-hub.se/10.1093/ntr/ntr088 PDF Version]
*[https://sci-hub.se/10.1093/ntr/ntr088 PDF Version]
*Citation: McQueen, A., Tower, S., & Sumner, W. (2011). Interviews With “Vapers”: Implications for Future Research With Electronic Cigarettes. Nicotine & Tobacco Research, 13(9), 860–867. doi:10.1093/ntr/ntr088
*Acknowledgement: This research was conducted independent of grant funding. AM is supported by a Mentored Research Scientist Grant from the American Cancer Society (CPPB-113766).




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*Conclusions “The 16 mg Ruyan V8 ENDD alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette. Evaluation of the ENDD for longer-term safety, potential for long-term use and efficacy as a cessation aid is needed.”
*Conclusions “The 16 mg Ruyan V8 ENDD alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette. Evaluation of the ENDD for longer-term safety, potential for long-term use and efficacy as a cessation aid is needed.”
*[https://sci-hub.se/10.1136/tc.2009.031567 PDF Version]
*[https://sci-hub.se/10.1136/tc.2009.031567 PDF Version]
*Citation: Bullen, C., McRobbie, H., Thornley, S., Glover, M., Lin, R., & Laugesen, M. (2010). Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tobacco Control, 19(2), 98–103. doi:10.1136/tc.2009.031567
*Acknowledgement: This project was funded by Ruyan Group (Holdings) Limited, Beijing and Hong Kong, via Health New Zealand Ltd. The study sponsors supplied the ENDDs used in the trial and funded the trial. The Clinical Trials Research Unit contracted with Health New Zealand Ltd to conduct the trial, independently of Ruyan Group (Holdings) Ltd. The trial design conduct, analysis and interpretation of results were conducted independently of the sponsors.




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*Our results suggest that ecigarettes are used mainly to quit smoking, and may be useful for this purpose.
*Our results suggest that ecigarettes are used mainly to quit smoking, and may be useful for this purpose.
*[https://link.springer.com/content/pdf/10.1186%2F1471-2458-10-231.pdf PDF Version]
*[https://link.springer.com/content/pdf/10.1186%2F1471-2458-10-231.pdf PDF Version]
*Citation: Etter, JF. Electronic cigarettes: a survey of users. BMC Public Health 10, 231 (2010). https://doi.org/10.1186/1471-2458-10-231




===2006: [https://tobaccocontrol.bmj.com/content/15/3/210 Role of snus in initiation and cessation of tobacco smoking in Sweden]===
===2006: [https://tobaccocontrol.bmj.com/content/15/3/210 Role of snus in initiation and cessation of tobacco smoking in Sweden]===
*Use of snus in Sweden is associated with a reduced risk of becoming a daily smoker, and increased likelihood of stopping smoking
*Use of snus in Sweden is associated with a reduced risk of becoming a daily smoker, and increased likelihood of stopping smoking
*Citation: Ramström LM, Foulds JRole of snus in initiation and cessation of tobacco smoking in Sweden, Tobacco Control 2006;15:210-214.
*Acknowledgement: LR owns shares in Pfizer Inc, and both he and JF have done paid consultancy work for Pfizer Inc and other agencies involved in public health. LR has periodically been employed as short term consultant with WHO and JF has provided testimony for plaintiffs in law suits against tobacco companies. None of the authors has received any financial support from the tobacco industry.




===2005: [https://tobaccocontrol.bmj.com/content/14/6/422 Is Swedish snus associated with smoking initiation or smoking cessation?]===
===2005: [https://tobaccocontrol.bmj.com/content/14/6/422 Is Swedish snus associated with smoking initiation or smoking cessation?]===
*“Among males participating in a large population based twin study in Sweden, snus use was associated with smoking cessation but not initiation.”
*“Among males participating in a large population based twin study in Sweden, snus use was associated with smoking cessation but not initiation.”
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/14/6/422.full.pdf PDF Version]  
*[https://tobaccocontrol.bmj.com/content/tobaccocontrol/14/6/422.full.pdf PDF Version]
*Citation: Furberg H, Bulik CM, Lerman C, et alIs Swedish snus associated with smoking initiation or smoking cessation?Tobacco Control 2005;14:422-424.
*Acknowledgement: This work was supported by CA-085839 to PFS


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