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==OCD (Obsessive Compulsive Disorder)== | ==OCD (Obsessive Compulsive Disorder)== | ||
==Pain== | ==Pain== | ||
===2013 [https://www.sciencedirect.com/science/article/abs/pii/S0014299913003270?via%3Dihub Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models] | |||
*Nicotine significantly reduced antiviral-dependent alterations of the nociceptive threshold. | |||
*Moreover, nicotine decreased neuropathic pain induced by repeated intraperitoneal administration of the anticancer agent oxaliplatin (2.4 mg/kg), lowering the hypersensitivity to mechanical and thermal stimuli. | |||
*Intraperitoneal nicotine administration controls neuropathic pain evoked by traumatic or toxic nervous system alterations. These results support the nAChR modulation as a possible therapeutic approach to the complex, undertreated chemotherapy-induced neuropathies. | |||
*[https://sci-hub.st/https://doi.org/10.1016/j.ejphar.2013.04.022 PDF Version] | |||
*Citation: Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Carla Ghelardini, Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models, European Journal of Pharmacology, Volume 711, Issues 1–3, 2013, Pages 87-94, ISSN 0014-2999, doi: 10.1016/j.ejphar.2013.04.022. | |||
*Acknowledgements: This work was supported by the Italian Ministry of Instruction, University and Research. | |||
*Keywords: nAChR; Dideoxycytidine; Oxaliplatin; Antiviral; Anticancer, pain, chemotherapy, nicotine, neuropathy | |||
==Parkinson Disease== | ==Parkinson Disease== | ||
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