ENDS Adults Who Smoke: Difference between revisions

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===2021: [https://ash.org.uk/wp-content/uploads/2021/06/Use-of-e-cigarettes-vapes-among-adults-in-Great-Britain-2021.pdf Use of e-cigarettes (vapes) among adults in  Great Britain]===
===2021: [https://ash.org.uk/wp-content/uploads/2021/06/Use-of-e-cigarettes-vapes-among-adults-in-Great-Britain-2021.pdf Use of e-cigarettes (vapes) among adults in  Great Britain]===
*This fact sheet analyses how behaviour and attitudes to e-cigarettes among adults aged 18 and over have changed over time. The data are taken from an annual survey, Smokefree GB
*Nearly two thirds of current vapers are ex-smokers (64.6%), and the proportion continues to grow, while the proportion who also smoke (known as dual users) has fallen to 30.5% in 2021.
*Fewer than 1% of never smokers are current vapers (amounting to 4.9% of vapers).
*As in previous years the main reason given by ex-smokers for vaping is to help them quit (36%) then to prevent relapse (20%).
*The main reason given by current smokers for vaping is to cut down (26%) then to help them quit (17%) and to prevent relapse (14%).
*Nearly a third of smokers incorrectly believe vaping is more or equally as harmful as smoking (32% compared to 34% in 2020).  
*Citation: Action on Smoking and Health (ASH). Use of e-cigarettes (vapes) among adults in Great Britain. 2021
*Citation: Action on Smoking and Health (ASH). Use of e-cigarettes (vapes) among adults in Great Britain. 2021




===2020: Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session===
===2020: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301047/ Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session]===
In E3, nicotine e-cigarettes plus counseling was superior to counseling alone for smoking cessation. Non-nicotine e-cigarettes plus counseling was also more effective compared with counseling alone though its effects on cessation were modest. This trial demonstrates the efficacy of e-cigarettes as a tool for smoking cessation compared with counseling alone.
*In E3, nicotine e-cigarettes plus counseling was superior to counseling alone for smoking cessation. Non-nicotine e-cigarettes plus counseling was also more effective compared with counseling alone though its effects on cessation were modest. This trial demonstrates the efficacy of e-cigarettes as a tool for smoking cessation compared with counseling alone.
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301047/pdf/11883_2020_Article_856.pdf PDF Version]
*Citation: Jia X, Al Rifai M, Liu J, Agarwala A, Gulati M, Virani SS. Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session. Curr Atheroscler Rep. 2020;22(8):32. Published 2020 Jun 18. doi:10.1007/s11883-020-00856-6
   
   


===2020: A magic bullet? The potential impact of e-cigarettes on the toll of cigarette smoking===
===2020: [https://academic.oup.com/ntr/article-abstract/23/4/654/5895499 A magic bullet? The potential impact of e-cigarettes on the toll of cigarette smoking]===
The combination of assumptions produces 360 possible scenarios. 357 (99%) yield positive estimates of life-years saved (LYS) due to vaping by 2100, from 143,000 to 65 million.  
*The combination of assumptions produces 360 possible scenarios. 357 (99%) yield positive estimates of life-years saved (LYS) due to vaping by 2100, from 143,000 to 65 million.  
The impact of vaping is greatest when it most helps smokers who otherwise have the greatest difficulty quitting smoking.
*The impact of vaping is greatest when it most helps smokers who otherwise have the greatest difficulty quitting smoking.
Vaping is highly likely to reduce smoking-produced mortality. Still, vaping is not “the” answer to the public health crisis created by smoking. Rather, it may well be a tool to add to the armamentarium of effective tobacco control measures.
*Vaping is highly likely to reduce smoking-produced mortality. Still, vaping is not “the” answer to the public health crisis created by smoking. Rather, it may well be a tool to add to the armamentarium of effective tobacco control measures.
Harm reduction can, and many would say should, be a part of the complex formula that will eventually bring about the demise of smoking.
*Harm reduction can, and many would say should, be a part of the complex formula that will eventually bring about the demise of smoking.
*[https://sci-hub.se/10.1093/ntr/ntaa160 PDF Version]
*Citation: Mendez, D., & Warner, K. E. (2020). A magic bullet? The potential impact of e-cigarettes on the toll of cigarette smoking. Nicotine & Tobacco Research. doi:10.1093/ntr/ntaa160
*Acknowledgement: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health (NIH) and FDA Center for Tobacco Products (CTP) (Award Number U54CA229974).
   
   


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===2020: Using e-cigarettes for smoking cessation: evaluation of a pilot project in the North West of England===
===2020: [https://journals.sagepub.com/doi/full/10.1177/1757913920912436 Using e-cigarettes for smoking cessation: evaluation of a pilot project in the North West of England]===
Of the 1022 participants who engaged with the pilot 614 were still engaged at 4 weeks, of whom 62% had quit smoking. Of those who still smoked tobacco at week 4, smoking had reduced from a baseline of 19.1 cigarettes/day to 8.7. Overall, 37% of those initially enrolled were confirmed to be using an e-cigarette on its own at follow-up. Successful quit was associated with occupation (unemployed, 33% vs intermediate, 47%) and residing in the less deprived quintiles of deprivation (50% vs 34% in the most deprived quintile.
*Of the 1022 participants who engaged with the pilot 614 were still engaged at 4 weeks, of whom 62% had quit smoking. Of those who still smoked tobacco at week 4, smoking had reduced from a baseline of 19.1 cigarettes/day to 8.7. Overall, 37% of those initially enrolled were confirmed to be using an e-cigarette on its own at follow-up. Successful quit was associated with occupation (unemployed, 33% vs intermediate, 47%) and residing in the less deprived quintiles of deprivation (50% vs 34% in the most deprived quintile.
E-cigarettes appear to be an effective nicotine replacement therapy
*E-cigarettes appear to be an effective nicotine replacement therapy
*[https://sci-hub.st/10.1093/ntr/ntaa182 PDF Version]
*Citation: OUP accepted manuscript. (2020). Nicotine & Tobacco Research. doi:10.1093/ntr/ntaa182
*Acknowledgement: This work was funded internally by NYU School of Global Public Health. DTL was also funded in part by the National Cancer Institute (P01CA200512).




===2020: Tobacco harm reduction in the 21st century===
===2020: [https://www.emerald.com/insight/content/doi/10.1108/DAT-02-2020-0007/full/html Tobacco harm reduction in the 21st century]===
In conclusion, to reduce smoking and to save millions of lives, tobacco harm reduction in the form of cigarette substitution with low-risk products appears to be a promising path. These products, although not completely risk-free, offer an alternative to quit or die. In consideration of the available evidence, advice to tobacco smokers should include trying substitute products. The obvious fact so often overlooked is that smoking is rewarding and people like to do it. Giving smokers an alternative with efficient nicotine delivery means that they might prefer one of these products over cigarettes.  
*Covers Snus and smokeless tobacco, Heat not burn, and  e-cigarettes
*In conclusion, to reduce smoking and to save millions of lives, tobacco harm reduction in the form of cigarette substitution with low-risk products appears to be a promising path. These products, although not completely risk-free, offer an alternative to quit or die. In consideration of the available evidence, advice to tobacco smokers should include trying substitute products. The obvious fact so often overlooked is that smoking is rewarding and people like to do it. Giving smokers an alternative with efficient nicotine delivery means that they might prefer one of these products over cigarettes.  
*[https://www.emerald.com/insight/content/doi/10.1108/DAT-02-2020-0007/full/pdf?title=tobacco-harm-reduction-in-the-21st-century PDF Version]
*Citation: O'Leary, R. and Polosa, R. (2020), "Tobacco harm reduction in the 21st century", Drugs and Alcohol Today, Vol. 20 No. 3, pp. 219-234. doi: 10.1108/DAT-02-2020-0007




===2019: Association Between Electronic Cigarette Use and Smoking Reduction in France===
===2019: [https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2737916 Association Between Electronic Cigarette Use and Smoking Reduction in France]===
Findings  This cohort study found that, among daily smokers in France, regular (daily) electronic cigarette use is associated with a significantly higher decrease in the number of cigarettes smoked per day as well as an increase in smoking cessation attempts. However, among former smokers, electronic cigarette use is associated with an increase in the rate of smoking relapse.
*This cohort study found that, among daily smokers in France, regular (daily) electronic cigarette use is associated with a significantly higher decrease in the number of cigarettes smoked per day as well as an increase in smoking cessation attempts. However, among former smokers, electronic cigarette use is associated with an increase in the rate of smoking relapse.
NOTE: Article that covers above study - Adults who vape are more likely to quit cigarettes, study finds
*[https://sci-hub.se/10.1001/jamainternmed.2019.1483 PDF Version]
“The study did find that the heightened risk of relapse disappeared in those who quit smoking more recently, which the researchers said may be due to improved e-cigarette technology.”
*Citation: Gomajee, R., El-Khoury, F., Goldberg, M., Zins, M., Lemogne, C., Wiernik, E., … Melchior, M. (2019). Association Between Electronic Cigarette Use and Smoking Reduction in France. JAMA Internal Medicine. doi:10.1001/jamainternmed.2019.1483
“For example, the study as a whole considered anybody who quit smoking from 2010 onward and found that, in that sample, vaping increased the risk of relapse. But when researchers only considered people who quit cigarettes as of 2013, former smokers were not more likely to relapse if they vaped.”
*Acknowledgement: The CONSTANCES (Consultants des Centres d’Examens de Santé) Cohort Study was supported and funded by the Caisse nationale d’assurance maladie des travailleurs salariés. The CONSTANCES Cohort Study is an “Infrastructure nationale en Biologie et Santé” is funded by grant ANR-11-INBS-0002 from Agence Nationale de la Recherche. CONSTANCES is also partly funded by MSD, AstraZeneca, and Lundbeck. The present analyses were supported by grant 2016-082 from Institut National du Cancer.
“The researchers noted in their study that "measures of plasma nicotine levels have shown that, compared with older models of [e-cigarettes], the new generation delivers higher levels of nicotine to the bloodstream," which may make them more satisfying.”
*'''NOTE''': Article that covers above study - [https://www.cnn.com/2019/07/15/health/e-cigarettes-quit-smoking-study/index.html?no-st=1565360238 Adults who vape are more likely to quit cigarettes, study finds]
“Other "technical improvements in [e-cigarettes] over time," they said, may also explain why people who recently quit smoking and switched to e-cigarettes were less likely to relapse than those who quit earlier.”
**“The study did find that the heightened risk of relapse disappeared in those who quit smoking more recently, which the researchers said may be due to improved e-cigarette technology.”
**“For example, the study as a whole considered anybody who quit smoking from 2010 onward and found that, in that sample, vaping increased the risk of relapse. But when researchers only considered people who quit cigarettes as of 2013, former smokers were not more likely to relapse if they vaped.”
**“The researchers noted in their study that "measures of plasma nicotine levels have shown that, compared with older models of [e-cigarettes], the new generation delivers higher levels of nicotine to the bloodstream," which may make them more satisfying.”
**“Other "technical improvements in [e-cigarettes] over time," they said, may also explain why people who recently quit smoking and switched to e-cigarettes were less likely to relapse than those who quit earlier.”


   
   
===2019: Association of prevalence of electronic cigarette use with smoking cessation and cigarette consumption in England: a time–series analysis between 2007 and 2017===
===2019: [https://onlinelibrary.wiley.com/doi/full/10.1111/add.14851 Association of prevalence of electronic cigarette use with smoking cessation and cigarette consumption in England: a time–series analysis between 2007 and 2017]===
The increase in prevalence of e‐cigarette use by smokers in England has been positively associated with an increase in success rates of quit attempts and overall quit rates
*The increase in prevalence of e‐cigarette use by smokers in England has been positively associated with an increase in success rates of quit attempts and overall quit rates
*[https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.14851 PDF Version]
*Citation: Beard, E., West, R., Michie, S., and Brown, J. (2020) Association of prevalence of electronic cigarette use with smoking cessation and cigarette consumption in England: a time–series analysis between 2006 and 2017. Addiction, 115: 961– 974. doi: 10.1111/add.14851.
*Acknowledgement: The STS is currently primarily funded by Cancer Research UK (C1417/A14135; C36048/A11654; C44576/A19501), and has previously also been funded by Pfizer, GlaxoSmithKline and the Department of Health.




===2019: Electronic Cigarette Use and Cigarette Abstinence Over 2 Years Among U.S. Smokers in the Population Assessment of Tobacco and Health Study===  
===2019: [https://academic.oup.com/ntr/article-abstract/22/5/728/5531618 Electronic Cigarette Use and Cigarette Abstinence Over 2 Years Among U.S. Smokers in the Population Assessment of Tobacco and Health Study]===  
In this nationally representative longitudinal cohort study of US adult cigarette smokers, daily e-cigarette use, compared to no e-cigarette use, was associated with a 77% increased odds of prolonged cigarette smoking abstinence over the subsequent 2 years. Regular use of e-cigarettes may help some smokers to stop smoking combustible cigarettes.
*In this nationally representative longitudinal cohort study of US adult cigarette smokers, daily e-cigarette use, compared to no e-cigarette use, was associated with a 77% increased odds of prolonged cigarette smoking abstinence over the subsequent 2 years. Regular use of e-cigarettes may help some smokers to stop smoking combustible cigarettes.
Article: Daily e-cigarette use may help smokers quit regular cigarettes
*[https://sci-hub.se/10.1093/ntr/ntz114 PDF Version]
 
*Citation: Kalkhoran, S., Chang, Y., & Rigotti, N. A. (2019). Electronic Cigarette Use and Cigarette Abstinence Over Two Years among U.S. Smokers in the Population Assessment of Tobacco and Health Study. Nicotine & Tobacco Research. doi:10.1093/ntr/ntz114
 
*Acknowledgement: This study was supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (K23HL136854 to Dr. Kalkhoran).  
===2019: Article: Adults who vape are more likely to quit cigarettes, study finds===
*Article: [https://medicalxpress.com/news/2019-07-daily-e-cigarette-smokers-regular-cigarettes.amp?__twitter_impression=true&fbclid=IwAR31bxC-WqHdBdIjXClI6fA9qOVsnPAP90sUGDAHHHJuW0xw-VANcuFsT1A Daily e-cigarette use may help smokers quit regular cigarettes]
“The study did find that the heightened risk of relapse disappeared in those who quit smoking more recently, which the researchers said may be due to improved e-cigarette technology.
“For example, the study as a whole considered anybody who quit smoking from 2010 onward and found that, in that sample, vaping increased the risk of relapse. But when researchers only considered people who quit cigarettes as of 2013, former smokers were not more likely to relapse if they vaped.
“The researchers noted in their study that "measures of plasma nicotine levels have shown that, compared with older models of [e-cigarettes], the new generation delivers higher levels of nicotine to the bloodstream," which may make them more satisfying.
“Other "technical improvements in [e-cigarettes] over time," they said, may also explain why people who recently quit smoking and switched to e-cigarettes were less likely to relapse than those who quit earlier.”




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===2017: Predicting Short-Term Uptake of Electronic Cigarettes: Effects of Nicotine, Subjective Effects, and Simulated Demand===
===2017: [https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntx269/4768299?redirectedFrom=fulltext Predicting Short-Term Uptake of Electronic Cigarettes: Effects of Nicotine, Subjective Effects, and Simulated Demand]===
Mean cigarettes per day decreased by 37% when e-cigarettes were available relative to baseline. Nicotine-containing cartridges were associated with greater use and craving reduction than 0 mg. Alleviation of withdrawal symptoms and taste and enjoyment factors predicted e-cigarette use.
*Mean cigarettes per day decreased by 37% when e-cigarettes were available relative to baseline. Nicotine-containing cartridges were associated with greater use and craving reduction than 0 mg. Alleviation of withdrawal symptoms and taste and enjoyment factors predicted e-cigarette use.
*[https://sci-hub.se/10.1093/ntr/ntx269 PDF Versioin]
*Citation: Tucker, M. R., Laugesen, M., Bullen, C., & Grace, R. C. (2017). Predicting Short-Term Uptake of Electronic Cigarettes: Effects of Nicotine, Subjective Effects, and Simulated Demand. Nicotine & Tobacco Research. doi:10.1093/ntr/ntx269
*Acknowledge: This research was funded by the Tobacco Control Research Tūranga: A programme of innovative research to halve the smoking prevalence in Aotearoa/New Zealand within a decade. The Tūranga is supported through funding from the Reducing Tobacco-related Harm Research Partnership, co-funded by the Health Research Council of New Zealand and the Ministry of Health of New Zealand (HRC grant: 11/818).
   
   


===2017: Cohort study of electronic cigarette use: effectiveness and safety at 24 months===
===2017: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520273/ Cohort study of electronic cigarette use: effectiveness and safety at 24 months]===
Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence).
*Of the e-cigarette users, 61.1% remained abstinent from tobacco (while 23.1% and 26.0% of tobacco-only smokers and dual users achieved tobacco abstinence).




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