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2020: Effect of Pod e-Cigarettes vs Cigarettes on Carcinogen Exposure Among African American and Latinx Smokers | ===2020: [https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2773075 Effect of Pod e-Cigarettes vs Cigarettes on Carcinogen Exposure Among African American and Latinx Smokers]=== | ||
This randomized clinical trial found that the use of NSPS (nicotine salt pod system) e-cigarettes for replacing cigarettes led to significant reduction in a primary pulmonary carcinogen, NNAL, for African American and Latinx smokers. There were also significant reductions in cigarettes smoked per day, co, and respiratory symptoms and no increase in nicotine exposure. Furthermore, about one-fourth of participants randomized to e-cigarettes were able to fully cease use of combustible cigarettes at week 6. Reduction in cigarettes and biomarkers of exposure in this study suggest potential of NSPS e-cigarettes as a harm reduction strategy for members of the 2 largest minority groups in the US who face significant health disparities. | *This randomized clinical trial found that the use of NSPS (nicotine salt pod system) e-cigarettes for replacing cigarettes led to significant reduction in a primary pulmonary carcinogen, NNAL, for African American and Latinx smokers. There were also significant reductions in cigarettes smoked per day, co, and respiratory symptoms and no increase in nicotine exposure. Furthermore, about one-fourth of participants randomized to e-cigarettes were able to fully cease use of combustible cigarettes at week 6. Reduction in cigarettes and biomarkers of exposure in this study suggest potential of NSPS e-cigarettes as a harm reduction strategy for members of the 2 largest minority groups in the US who face significant health disparities. | ||
*[https://scholar.google.com/scholar_url?url=https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2773075/pulvers_2020_oi_200857_1605044939.46773.pdf&hl=en&sa=T&oi=ucasa&ct=ufr&ei=FLgoYeCCHYyMyASo-pvoCg&scisig=AAGBfm3a0sSxuUXLCqUoW6xwH1FJQNMYEw PDF Version] | |||
*Citation: Pulvers K, Nollen NL, Rice M, et al. Effect of Pod e-Cigarettes vs Cigarettes on Carcinogen Exposure Among African American and Latinx Smokers: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(11):e2026324. doi:10.1001/jamanetworkopen.2020.26324 | |||
*Acknowledgement: Drs Pulvers and Nollen and Ms Rice were supported by grant No. 5SC3GM122628 from the National Institutes of Health (NIH). Drs Schmid and Ahluwalia were supported in part by grant No. P20GM130414, from the NIH-funded Center of Biomedical Research Excellence (COBRE). Dr Schmid was partially supported by Institutional Development Award No. U54GM115677 from the National Institute of General Medical Sciences of the NIH, which funds Advance Clinical and Translational Research (Advance-CTR). | |||
===2020: [https://www.sciencedirect.com/science/article/abs/pii/S0304389420314060 Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells]=== | |||
*We first report that HTP (Heated Tobacco Product) delivers slightly less nicotine and emits much lower amounts of carbonyl and PAH compounds than tobacco cigarettes. | |||
*However, HTP emissions still contain carcinogenic compounds (e.g. formaldehyde, acetaldehyde and benzo[a]pyrene) and the amounts of carbonyls and PAHs in HTP aerosols are higher than in e-cig vapours (vapor). | |||
*In accordance with the levels of toxic compounds in each aerosol, HTP aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours. | |||
*HTP and e-cig have the potential to increase oxidative stress and inflammatory response, in a manner very similar to that of cigarette smoke, but only after a more intensive exposure. In addition, our data support that e-cig use at higher power settings emit higher carbonyl and PAH compounds and, consequently, generate more oxidative stress. | |||
*Finally, this study contributes to a better understanding of HTP and e-cig emission properties and their related toxicological impacts and provides important data needed for risk assessment purposes, by demonstrating that HTP might be less harmful than tobacco cigarettes but considerably more harmful than e-cig. | |||
*[https://pdf.sciencedirectassets.com/271390/1-s2.0-S0304389420X00161/1-s2.0-S0304389420314060/am.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEDoaCXVzLWVhc3QtMSJGMEQCIC20cepD3xWxO%2BHPfyvs9%2Fj4JkBZED8%2FyZivSvEh3DKqAiBV6d6I8BClyK7mRN2vsTLG4tpeRZvzFFTRm6iTWpF4jyr6AwhzEAQaDDA1OTAwMzU0Njg2NSIMned%2B2ZjGntQWfryIKtcDCllJ3BD59q7X1IUBsGkzgt4LlI8%2FeSiu7t8e8B0EG%2B9HDHMW8J%2BB8HskjtV8Nt7aw1o2iLkrks2014KOvf8SZuX5VRpbqj3m%2Fskb7%2BUDG9%2ByimsdJHgenWh4UjB0Y8fFA6bJuOtlbLYAKfbZL45ytPv0ne9iwFcCunPJJyZctT%2BG%2FdWtC%2FKtYDePqALnmkA54fA7C8aCG1FfAbKOTLP%2Fj68Zn5oKiaTP1iCuepTIC9PEtIbW3jDOHZxdeekOwvsOjmNil3T0bjm6xsBXMtp%2F1qjve6r0R%2F7GboJDGi9kE24Lf%2FvMAyQke%2BeauRLigBTGlm6ZGBqoJLYuOCXS%2FOg7SDhxVmvGzteddKKt6rpu0Tdo4Y2zcfaBHWAUELShFRp8GHjEWgFW1WKMZlMxdbyuVS7D6zK7lY8Rl1QCS8UDTYPJ9KgYYZLyBzBAjoZoBHqDOfEd2Pq27F%2FYGm1DnUv%2ByHpVpnas1kInRwTQP8lCidzbXQ5amJYnVPdmK0e19y1N0qmneUxb7c4l8U%2BkJ%2FOvQBs5NeiFB16v3dt01MdJJgM5zytE%2FjVJlSDx6o46Cf86rPbsCjz679RrmXM4LZ9pqkLYrGu8OVkgwCfxPyD5lz4DRL1lC6pzMO%2FfookGOqYBW4NimJC3eAF1AV5d2eDsUfNKwuiOp6l7LfvJX79t0%2BfegtSoPQAw7I%2FuhraeUNkUnCPTJiJpjyvTFI3xqcdZ2U%2FX%2BoGXCUbuw6dW4ep4ENLAdCmbPDpGkSzAPPmsNYetpOykif9Stz9O1Q3jdKAQEU2sfmVcyi76UYFI28ZPRcxx39CYrSpCIf3Wl0aulvqVJwgwpPEudIFT045A6LSCwcpnedfscg%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20210827T101042Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYXMGQQFJ3%2F20210827%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=f6c7708f1578fd81e69a1e8d00ced8d31682c3b06a80829dc98b39b50a0b73e8&hash=e8aba33ee6d0e02c3f302c62a141e2e530d9bd77a9c95cc0c734640f9a0b5e8b&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0304389420314060&tid=pdf-78980aac-f8f1-4bf1-8d13-dac5c6840db5&sid=f2637e30858078455208ee9417a65d1e0937gxrqa&type=client PDF Version] | |||
*Citation: Romain Dusautoir, Gianni Zarcone, Marie Verriele, Guillaume Garçon, Isabelle Fronval, Nicolas Beauval, Delphine Allorge, Véronique Riffault, Nadine Locoge, Jean-Marc Lo-Guidice, Sébastien Anthérieu, Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells, Journal of Hazardous Materials, Volume 401, 2021, 123417, ISSN 0304-3894, doi:10.1016/j.jhazmat.2020.123417 | |||
*Acknowledgement: This work was supported by the French Institute of Cancer (INCa) and the French Institute for Public Health Research (IResP): Contracts n°INCa_11505 and n°INCa_13648. | |||
2020: Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System (PDF 9 pages) | 2020: Five-Day Changes in Biomarkers of Exposure Among Adult Smokers After Completely Switching From Combustible Cigarettes to a Nicotine-Salt Pod System (PDF 9 pages) | ||
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