Translations:ENDS Toxicity / Carcinogenic/46/en

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  • In the presence and absence of metabolic activation, e-cigarette ACM and aerosol were deemed non-mutagenic in tester strains TA98 and TA100, under the test conditions described previously, despite clear positive control responses. Conversely, 3R4F cigarette smoke TPM and freshly generated whole smoke were clearly positive.
  • In the case of freshly generated cigarette smoke, a positive response in both strains was observed within 24 min, whereas e-cigarette aerosols remained negative up to 3 h.
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  • Citation: Thorne, D., Crooks, I., Hollings, M., Seymour, A., Meredith, C., & Gaca, M. (2016). The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 812, 29–38. doi:10.1016/j.mrgentox.2016.10.005
  • Acknowledgement: The authors are employees of British American Tobacco or Covance Laboratories Ltd. Covance Laboratories Ltd., Harrogate, UK, conducted all experimental work and were funded by BritishAmerican Tobacco. Nicoventures Ltd., UK, is a wholly-owned subsidiary of British American Tobacco.